Acute and Long-Term Behavioural Effects of MDMA in Adolescent Rats
Esther Remmelink
The Open Addiction Journal March 29, 2011 DOI: 10.2174/1874941001104010042 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study (animal study) Peer reviewed |
|---|---|
| Population | Adolescent rats |
| Intervention | MDMA |
| Topics | MDMA |
| Key findings | The abstract states the study's objectives but does not report any findings or conclusions. It indicates that the research investigates whether MDMA's effects in adult rats—acute increases in social interaction and long-term decreases in social interaction, increased anxiety, and impaired object recognition memory—also occur in adolescent rats, and whether social context mediates adolescent preference for MDMA. |
Abstract
Acute MDMA, even at low doses, increases social interaction in adult rats [1] while on the long-term its consumption produces a decrease in social interaction, an increase in anxiety and impaired object recognition memory [2, 3]. This study investigated whether MDMA has the same effects in adolescent rats. Additionally, we investigated whether the preference of adolescent rats for MDMA was mediated by social context.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cites 2
- PRECLINICAL STUDY: Atypical development of behavioural sensitization to 3,4‐methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) in adolescent rats and its expression in adulthood: role of the MDMA chirality Addiction Biology 2010
- A long hangover from party drugs: residual proteomic changes in the hippocampus of rats 8 weeks after γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination. Neurochemistry International March 19, 2010