Page 4 of 5: studies 61 to 80 of 97, newest first. Back to the MDMA overview
Psychopharmacology May 2, 2010
Caffeine promotes dopamine D1 receptor-mediated body temperature, heart rate and behavioural responses to MDMA ('ecstasy').
Psychopharmacology May 2010 Jessica McClung, William E Fantegrossi, Leonard L. Howell
The effectiveness of MDMA and its enantiomers to reinstate responding previously maintained by drug self-administration has not been thoroughly investigated. The present study was designed to compare the reinstatement effects of amphetamine, the piperazine-analog BZP, SR(+/-)-MDMA, S(+)-MDMA, R(-)-MDMA, and fenfluramine on behavior maintained under a second-order schedule of intravenous...
Accident; Analysis and Prevention May 1, 2010
Risky car following in abstinent users of MDMA.
British Journal of Pharmacology May 1, 2010
Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity.
Toxicology April 11, 2010 Helena Pontes, Paula Guedes de Pinho, Eduarda Fernandes et al.
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy), a drug of abuse commonly consumed at rave parties, is often taken in a polydrug abuse scenario, ethanol being one of the most associated drugs. Both MDMA and ethanol are mainly metabolized in the liver with formation of toxic metabolites. Our working hypothesis is that ethanol can modify the metabolism of MDMA through the cytochrome P450...
Emergency Medicine Journal April 8, 2010 Cédric M. Hysek, Franz X. Vollenweider, Matthias E. Liechti 50 citations
The results of this study indicate that beta-blockers may prevent increases in heart rate but not hypertensive and adverse effects of MDMA.
Current drug targets April 2010 Patricia Robledo
3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") is an amphetamine derivative with psychostimulant properties. This substance is widely used around the world by young adults in recreational settings. One of the most remarkable characteristic of ecstasy users is the concurrent consumption of several other drugs of abuse including psychostimulants, alcohol, tobacco, LSD, cannabis and opioids....
The FASEB Journal April 1, 2010 Kevin T. Ball
MDMA is a widely used amphetamine derivative that increases dopamine and serotonin transmission via its interaction with monoamine transporters. Compared to other psychostimulants, little is known about the long‐term neurobehavioral effects of MDMA. We conducted a series of studies aimed at elucidating the effects of MDMA administration on behavior, limbic cortico‐striatal neuronal structure,...
The International Journal of Neuropsychopharmacology March 25, 2010 Joyce Colussi‐mas, Richard J. Wise, Alex Howard et al. 51 citations
In laboratory animals, exposure to priming injections of 3,4-methylenedioxymethamphetamine (MDMA) produced drug seeking following extinction of MDMA self-administration. This study aimed to evaluate whether the magnitude of drug seeking was related to latency to acquisition of MDMA self-administration and increases in striatal dopamine, as measured by in-vivo microdialysis. Rats were given...
Behavioral and Brain Functions March 22, 2010 Carmen Manzanedo, Marta Rodríguez‐arias, Manuel Daza‐losada et al. 36 citations
Abstract Background Numerous reports indicate that MDMA users consume other psychoactive drugs, among which cannabis is one of the most common. The aim of the present study was to evaluate, using the conditioned place preference, the effect of the cannabinoid agonist WIN 55,212-2 on the rewarding effects of MDMA in mice. Methods In the first experiment adolescent mice were initially conditioned...
Neurochemistry International March 19, 2010
A long hangover from party drugs: residual proteomic changes in the hippocampus of rats 8 weeks after γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination.
Behavioural Brain Research March 5, 2010 Rómeó D. Andó, Csaba Ádori, Eszter Kirilly et al.
To assess the functional state of the serotonergic system, the acute behavioural and brain metabolic effect of SSRI antidepressants were studied during the recovery period after MDMA-induced neuronal damage. The effects of the SSRI fluoxetine and the serotonin receptor agonist meta-chloro-phenylpiperazine (m-CPP) were investigated in the social interaction test in Dark Agouti rats, 6 months...
British Journal of Pharmacology March 3, 2010 James R. Docherty, Ar Green 88 citations
Hyperthermia is probably the most widely known acute adverse event that can follow ingestion of 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy) by recreational users. The effect of MDMA on body temperature is complex because the drug has actions on all three major monoamine neurotransmitters [5‐hydroxytryptamine (5‐HT), dopamine and noradrenaline], both by amine release and by direct receptor...
Toxicological sciences : an official journal of the Society of Toxicology March 2010 Déborah Hirt, Julien Fonsart, Marie-Claude Menet et al.
The pharmacokinetics of the recreational drug 3,4-methylenedioxymethamphetamine (MDMA) and its mains metabolites have never been modeled together. We therefore designed a model with which to analyze the pharmacokinetics of MDMA, 3,4-methylenedioxyamphetamine (MDA), 4-hydroxy-3-methoxymethamphetamine (HMMA), and 4-hydroxy-3-methoxyamphetamine (HMA) and to test the effect of covariates like...
Psychopharmacology March 1, 2010
Effects of repeated MDMA administration on the motivation for palatable food and extinction of operant responding in mice.
Substance Use & Misuse March 1, 2010 Ornella Corazza, Fabrizio Schifano 43 citations
Increase in recreational ketamine use may be a cause for concern. We aimed here at assessing, in a sample of ketamine misusers, concordance between the typical near-death experience (NDE) features and the on-drug psychoactive effects the subjects experienced. In 2003-2005, a sample of previous ketamine misusers recollecting a ketamine-related NDE were recruited through snowballing and screened...
Toxicology Letters February 24, 2010
Identification of post-generation effect of 3,4-methylenedioxymethamphetamine on the mouse brain by large-scale gene expression analysis.
ACS Chemical Neuroscience February 23, 2010
Reduced 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-initiated oxidative DNA damage and neurodegeneration in prostaglandin H synthase-1 knockout mice.
February 16, 2010 Margaret Stutley
Shamanism is one of the earliest and farthest-reaching magical and religious traditions, vestiges of which still underlie the major religious faiths of the modern world. The function of the shaman is to show his or her people the unseen powers behind the mere appearances of nature, as experienced through intuition, in trance states, or during ecstatic mystical visions. Shamans possess healing...
PLoS One February 10, 2010 Clara Touriño, Andreas Zimmer, Olga Valverde 55 citations
The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, the main psychoactive compound of cannabis, produces hypothermic, anti-inflammatory and...