October 20, 2026
Christina Chwyl, Mary K. Lear, Jason B. Luoma
preprint
By fostering certain self-transcendent experiences (STE)—those characterized by interconnectedness and other-oriented emotions—3,4-Methylenedioxymethamphetamine (MDMA)-assisted therapy (MDMA-AT) has been hypothesized to disrupt social anxiety disorder maintenance processes, including negative self-focus, self-criticism, and isolation, thereby enhancing wellbeing. This secondary analysis used...
Psychopharmacology
October 17, 2026
Sean P. Goldy, Kelcy A Klein, David B. Yaden et al.
MDMA is increasingly being studied for therapeutic applications, yet the prevalence and characteristics of post-acute negative effects remain debated. We aimed to characterize MDMA's post-acute negative effects, including prevalence and symptom profile among recreational users. Given preclinical work and limited human evidence suggesting that certain supplements and antidepressants may mitigate...
Asian Journal of Pediatric Research
October 8, 2026
Soukaina Bendouz, Hind Lachraf, Hanane Laji et al.
Aims: To report an unusual presentation of suspected accidental 3,4-methylenedioxymethamphetamine (MDMA) intoxication as afebrile convulsive status epilepticus (CSE) in a toddler and to emphasise the importance of considering toxicological causes when conventional investigations are unrevealing. Presentation of Case: A previously healthy 20-month-old boy presented with generalised afebrile CSE...
Forensic Science International
October 8, 2026
Marina Charest, Emilia Gianola, Lucas Jaquet et al.
Chemical profiling of illicit drugs has traditionally relied on laboratory-based techniques such as gas chromatography-mass spectrometry (GC-MS). Recent developments in portable drug testing devices have facilitated the decentralization of forensic capabilities, enabling field users to obtain rapid results. In this study, portable near-infrared (NIR) spectroscopy was evaluated for the chemical...
September 29, 2026
Paul S. Links
Considere la neuromodulación para pacientes con TLP y depresión mayor comórbida que no hayan respondido a antidepresivos y otros medicamentos. La evidencia de revisiones sistemáticas respalda un papel complementario en estos casos. Al usar ketamina en el TLP, vigile cuidadosamente la aparición de conductas desinhibidas y el aumento de la ideación suicida. Los reportes de casos han documentado...
September 29, 2026
Paul S. Links
Envisagez la neuromodulation pour les patients atteints de trouble de la personnalité borderline présentant une dépression majeure comorbide et un échec des antidépresseurs et d'autres médicaments. Les données d'une revue systématique soutiennent un rôle complémentaire dans ces cas. Lors de l'utilisation de la kétamine dans le trouble de la personnalité borderline, surveillez attentivement les...
September 29, 2026
Paul S. Links
Considere a neuromodulação para pacientes com TPB e depressão maior comórbida que não responderam a antidepressivos e outras medicações. Evidências de revisões sistemáticas apoiam um papel complementar nesses casos. Ao utilizar cetamina no TPB, monitore cuidadosamente comportamentos desinibidos e aumento da ideação suicida. Relatos de caso documentaram ambas as reações como efeitos negativos. A...
September 29, 2026
Paul S. Links
Considerare la neuromodulazione per i pazienti con disturbo borderline di personalità e depressione maggiore in comorbilità che non hanno risposto agli antidepressivi e ad altri farmaci. Le evidenze delle revisioni sistematiche supportano un ruolo supplementare in questi casi. Quando si utilizza la ketamina nel disturbo borderline di personalità, monitorare attentamente eventuali comportamenti...
September 29, 2026
Paul S. Links
Warto rozważyć neuromodulację u pacjentów z zaburzeniem osobowości typu borderline i współwystępującą dużą depresją, u których leki przeciwdepresyjne i inne farmakoterapie okazały się nieskuteczne. Dane z przeglądów systematycznych wspierają jej rolę jako terapii uzupełniającej w takich przypadkach. Stosując ketaminę u pacjentów z zaburzeniem osobowości typu borderline, należy uważnie...
September 29, 2026
Paul S. Links
Consider neuromodulation for BPD patients with comorbid major depression who have failed antidepressants and other medications. Systematic review evidence supports a supplementary role in these cases. When using ketamine in BPD, monitor carefully for disinhibited behaviors and increased suicidal ideation. Case reports have documented both as negative reactions. MDMA-assisted psychotherapy has...
September 29, 2026
Paul S. Links
Overweeg neuromodulatie voor patiënten met borderline persoonlijkheidsstoornis en comorbide majeure depressie bij wie antidepressiva en andere medicatie hebben gefaald. Systematische review-evidentie ondersteunt een aanvullende rol in deze gevallen. Let bij het gebruik van ketamine bij borderline persoonlijkheidsstoornis goed op ontremd gedrag en toegenomen suïcidale ideatie. Casusrapporten...
September 29, 2026
Paul S. Links
Ziehen Sie Neuromodulation bei Patienten mit Borderline-Persönlichkeitsstörung und komorbider Major Depression in Betracht, bei denen Antidepressiva und andere Medikamente versagt haben. Die Evidenz aus systematischen Übersichtsarbeiten stützt eine ergänzende Rolle in diesen Fällen. Achten Sie bei der Anwendung von Ketamin bei Borderline-Persönlichkeitsstörung sorgfältig auf enthemmtes...
September 29, 2026
Paul S. Links
Antidepresanlara ve diğer ilaçlara yanıt vermemiş komorbid majör depresyonu olan BKB hastalarında nöromodülasyonu değerlendirin. Sistematik derleme kanıtları bu vakalarda tamamlayıcı bir rolü desteklemektedir. BKB'de ketamin kullanırken, dezinhibe davranışlar ve artmış intihar düşüncesi açısından dikkatle izleyin. Olgu sunumları her ikisini de olumsuz reaksiyon olarak belgelemiştir. MDMA...
JAMA Network Open
September 29, 2026
Otto Simonsson, Melissa Bradley, Joshua Curtis Black et al.
This cross-sectional study describes health outcomes attributed to recent use of psilocybin, lysergic acid diethylamide (LSD), 3,4-methylenedioxymethamphetamine (MDMA), ibogaine, and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a nationally representative survey of US adults.
International Journal of Innovative Technologies in Social Science
September 28, 2026
Klaudia Karolina Wójcik, Michal Kieres, Krzysztof Sebastian Habirek et al.
The article aims to compare receptor mechanisms related to neurotransmitters for some of the most widely used psychoactive substances - amphetamine, cocaine, ecstasy (MDMA), and psilocybin - and to link these mechanisms to cardiovascular effects, thermoregulation, and neurotoxicity. The review is based mainly on in vitro studies on transporters and receptors, animal models, and controlled...
Figshare
September 25, 2026
Stephan Ludewig
preprint
Impaired cognitive performance and increased levels of anxiety and depressiveness have been reported following chronic use of the recreational drug 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”). The aim of this study was to investigate whether memory functions and mood states are affected by two moderate doses of MDMA administered to healthy volunteers at intervals of two weeks, and hence...
ادبیات عرفانی
September 17, 2026
Haniye Pakravan, Ehsan Reisi
Ecstatic rituals are regarded as among the oldest religious concepts across diverse cultures. These rituals occupy a central and foundational position within certain spiritual traditions and belief systems, while in other religious or cultural contexts, they are rejected or marginalized. In several intellectual and faith-based traditions, trance is understood as a form of altered consciousness...
European Journal of Psychotraumatology
September 14, 2026
Roee Admon, Ophir Netzer, Noa Magal et al.
Background: The 7 October 2023 attack in southern Israel was one of the deadliest terror attacks in modern history, with 1,182 fatalities, more than 4,000 wounded individuals, and 251 hostages. The Nova music festival, an all-night outdoor rave near the Gaza border, suffered the highest number of civilian casualties, with more than 370 festival attendees killed. Survivors were exposed to...
Orvosi hetilap
September 13, 2026
Szabolcs Kéri
Over the past five years, the literature on the psychiatric use of psychedelic and related treatments has expanded substantially. Several randomized controlled trials and pooled analyses have been conducted in mood disorders, treatment-resistant depression, and post-traumatic stress disorder. Trial methodology, however, remains a fundamental source of uncertainty, and despite the popularity of...
PsyArXiv Preprints
September 11, 2026
preprint
Background 3,4-Methylenedioxymethamphetamine (MDMA) is associated with distinctive prosocial and empathogenic effects, yet the consistency and scope of its impact on social cognition in humans remain unclear. Although numerous placebo-controlled studies have examined MDMA’s acute social effects, findings vary widely across subjective and behavioural domains. Methods We conducted a systematic...