Reduced 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-initiated oxidative DNA damage and neurodegeneration in prostaglandin H synthase-1 knockout mice.
ACS Chemical Neuroscience February 23, 2010 DOI: 10.1021/cn900022w (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical experimental study Peer reviewed |
|---|---|
| Population | Mice (PGHS-1 knockout and wild-type) |
| Intervention | MDMA |
| Topics | MDMA |
| Key findings | PGHS-1 knockout mice exhibited reduced MDMA-initiated oxidative DNA damage and neurodegeneration compared to wild-type mice, indicating that PGHS-1 contributes to MDMA's neurotoxic effects. |
Abstract
Reduced 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-initiated oxidative DNA damage and neurodegeneration in prostaglandin H synthase-1 knockout mice.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 2
- Of mice and men on MDMA: a translational comparison of the neuropsychobiological effects of 3,4-methylenedioxymethamphetamine ('Ecstasy'). Brain Research November 14, 2019
- Intermolecular interactions between DNA and methamphetamine, amphetamine, ecstasy and their major metabolites. Journal of biomolecular structure & dynamics September 2018
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- Human Pharmacology of MDMA Therapeutic Drug Monitoring March 19, 2004
- Memory impairment in abstinent MDMA ("Ecstasy") users Neurology December 1, 1998
- Gender differences in the subjective effects of MDMA Psychopharmacology March 5, 2001
and 11 more in the library