Page 2 of 2: studies 21 to 35 of 35, newest first. Back to the MDMA overview
Anthropology of Consciousness September 1, 2003 Evajane N. Fridman 21 citations
Nine Worlds of SEID‐MAGIC: Ecstasy and Neo‐Shamanism in North European Paganism. Jenny Blain. London and New York: Routledge, 2001. 192 pages $20.95 Paperback.
Nitric oxide : biology and chemistry August 2003 Karen L. Anderson, Yossef Itzhak
Repeated exposure to psychostimulants such as cocaine and amphetamines results in behavioral sensitization, a paradigm thought to be relevant to drug craving and addiction in humans. We have previously shown that the induction, expression, and maintenance of psychomotor sensitization to cocaine, methamphetamine, and methylphenidate (indirect dopamine agonists) are blocked by co-administration...
The American journal of the medical sciences August 2003 Milos N Budisavljevic, Lisa Stewart, Steven A Sahn et al.
We present a case of acute, symptomatic hyponatremia in a young woman that developed after use of 3,4-methylenedioxymethylamphetamine (MDMA), more commonly known as "ecstasy." The patient was treated with 5% saline and had complete recovery. The pathogenesis of MDMA-associated hyponatremia involves excessive water intake and inappropriately elevated antidiuretic hormone (ADH) levels. It seems...
Journal of Neural Transmission July 1, 2003 H B Lebsanft, Andreas Mayerhofer, Karl-A Kovar et al.
3,4-Methylenedioxymethamphetamine (MDMA) has recently been hypothesized to be effective against the symptoms of Parkinson's disease. Therefore we tested the effects of MDMA-derivatives in the rotational behavioural model. Male Sprague Dawley rats were lesioned unilaterally with 6-hydroxydopamine at the medial forebrain bundle. MDMA was administered at doses of 2.5, 5.0 and 10.0 mg/kg, its...
Molecular Pharmacology June 2003 Vincent Setola, Sandra J Hufeisen, K Jane Grande-Allen et al.
Recent findings have implicated the 5-hydroxytryptamine 2B (5-HT2B) serotonin receptor in mediating the heart valve fibroplasia [valvular heart disease (VHD)] and primary pulmonary hypertension observed in patients taking the now-banned appetite suppressant fenfluramine (Pondimin, Redux). Via large-scale, random screening of a portion of the receptorome, we have discovered that the amphetamine...
Neurotoxicology June 2003 John F Bowyer, John F Young, William Slikker et al.
Plasma levels of parent compounds and metabolites were determined in adult rhesus monkeys after doses of either 5mg/kg d-fenfluramine (FEN) or 10mg/kg d-3, 4-methylenedioxymethamphetamine (MDMA) i.m. twice daily for four consecutive days. These treatment regimens have been previously shown to produce long-term serotonin (5-HT) depletions. Peak plasma levels of 2.0+/-0.4 microM FEN were reached...
Brain research. Brain research reviews May 2003 Johnalyn Lyles, Jean Lud Cadet
Methylenedioxymethamphetamine (MDMA, Ecstasy) is a very popular drug of abuse. This has led to new intense concerns relevant to its nefarious neuropsychiatric effects. These adverse events might be related to the neurotoxic effects of the drug. Although the mechanisms of MDMA-induced neurotoxicity remain to be fully characterized, exposure to the drug can cause acute and long-term neurotoxic...
Pharmacology & Therapeutics April 2003 J C Cole, Harry Sumnall
Ecstasy is the second most widely abused illegal drug in Europe. Ecstasy is the colloquial name for 3,4-methylenedioxymethamphetamine (MDMA), but not all Ecstasy tablets contain MDMA. When taken in hot, crowded environments, Ecstasy/MDMA users have developed acute complications that have had fatal consequences. Epidemiological evidence indicates that adverse reactions to Ecstasy/MDMA...
Brain Research March 25, 2003 Michael T. Williams, Laronda L. Morford, Sandra L. Wood et al. 66 citations
Previously, we have shown that rats administered MDMA from postnatal (P) days 11-20 had reductions in body weight during the period of treatment and as adults they had deficits in sequential and spatial learning and memory. In the present study, to control for weight reductions, we used litters with double the number of offspring to induce growth restriction comparable to that of standard size...
Revista Brasileira de Psiquiatria March 2003 Stella Pereira De Almeida, Maria Teresa Araujo Silva
As there are no studies about the use of ecstasy in Brazil, our aim was to identify the effects and patterns of use of this substance among users in the city of São Paulo. Subjects were recruited through the snowball technique. Fifty-two subjects of both genders who had been using ecstasy frequently and recently were interviewed. The instrument was a self-reported and anonymous questionnaire....
Addiction February 20, 2003 Erkki Vuori, John A. Henry, Ilkka Ojanperä et al. 113 citations
ABSTRACT Four deaths following the ingestion of moclobemide and MDMA (‘ecstasy’) are described. The probable cause of death in each case was serotonin syndrome as a result of an interaction between the two drugs. As none of the victims had been prescribed moclobemide it seems that each had taken the drug to enhance the effects of MDMA, with fatal consequences. Warnings are needed against...
Journal of Health & Social Policy 2003 Lauren Dundes
Since dangerous additives to the drug ecstasy can cause potentially lethal hyperthermia, the organization DanceSafe tests ecstasy for such adulterants. This study of over 700 college students examined whether individuals will use or abstain from ecstasy regardless of DanceSafe's presence at raves or whether DanceSafe erodes a powerful deterrent (i.e., the fear of hazardous additives) which may...
Pharmacology 2003 Gudrun Wakonigg, Katja Sturm, Alois Saria et al.
Although ‘ecstasy’ (3,4-methylenedioxymethamphetamine, MDMA) is, after marijuana, the second most prevalent illegal drug of abuse in European adolescents, animal experimental evidence of MDMA’s reinforcing effect has remained scarce, particularly in the rodent model, raising questions about the robustness of MDMA’s reinforcing effect under controlled laboratory conditions. In the present rat...
Cognitive Neuropsychiatry 2003 Konstantine K. Zakzanis, Donald A. Young, Zachariah Campbell 22 citations
Introduction: Quantitative evidence has begun to emerge where human studies suggest that repeated recreational use of +/- 3,4-methylenedioxy-methamphetamine (MDMA or "Ecstasy") produces lasting impairments in explicit memory. The purpose of this investigation was to further explore the nature and pattern of component memory processes in abstinent MDMA users. Methods: Accordingly, 15 MDMA users...
Free Radical Research 2003 Jun Zhou, Peng Chen, Ye Zhou et al. 45 citations
OBJECTIVE: To investigate whether 3,4-methylenedioxymethamphetamine abuse (MDMA abuse) may cause oxidative stress and potential free radical damage in the bodies of MDMA abusers (MA), and to explore the mechanisms by which MDMA abuse may be causing oxidative stress. METHODS: One hundred and twenty MA and 120 healthy volunteers (HV) were enrolled in a random control study design, in which the...