Neuropsychopharmacology
October 2017
Rachel A Rabin, Mera S Barr, Michelle S Goodman et al.
Cross-sectional studies of the effects of cannabis on cognition in schizophrenia have produced mixed results. Heavy and persistent cannabis use in schizophrenia is a common clinical problem, and effects of controlled abstinence from cannabis in these patients have not been carefully evaluated. The present study sought to determine the effects of cannabis abstinence on cognition in patients with...
Human Psychopharmacology: Clinical and Experimental
September 25, 2007
Konstantine K. Zakzanis, Zachariah Campbell, Diana Jovanovski
87 citations
Abstract A growing number of empirical studies have found varying neuropsychological impairments associated with use of 3,4‐methylenedioxymethamphetamine (MDMA) use. We set out to determine to what extent neuropsychological abilities are impaired in MDMA users. To do so, meta‐analytical methods were used to determine the magnitude of neuropsychological impairment in MDMA users across...
Neurology
March 13, 2006
Konstantine K. Zakzanis, Zachariah Campbell
54 citations
The authors further investigated the functional consequences of continued neurotoxicity of (+/-)3,4-methylenedioxymethamphetamine (MDMA) use. Fifteen participants who were previously given a brief neuropsychological battery were tested for a third time 2 years after baseline. At 2 years, seven participants were still using MDMA, whereas eight participants had become abstinent from MDMA since...
Cognitive Neuropsychiatry
2003
Konstantine K. Zakzanis, Donald A. Young, Zachariah Campbell
22 citations
Introduction: Quantitative evidence has begun to emerge where human studies suggest that repeated recreational use of +/- 3,4-methylenedioxy-methamphetamine (MDMA or "Ecstasy") produces lasting impairments in explicit memory. The purpose of this investigation was to further explore the nature and pattern of component memory processes in abstinent MDMA users. Methods: Accordingly, 15 MDMA users...
Neurology
April 10, 2001
Konstantine K. Zakzanis, Donald A. Young
122 citations
To examine the neurotoxic potential of continued MDMA ("Ecstasy") use in humans and its functional consequences over the course of 1 year, 15 MDMA users participated in a longitudinal study in which they completed a brief neuropsychological test battery composed mainly of retrospective and prospective memory tasks. Subjects were abstinent for 2 weeks on initial and 1-year testing. Continued use...