Revista Brasileira de Psiquiatria
September 9, 2026
Lisbeth Strandberg, Thiago P Fernandes, Irina I Shoshina et al.
Smoking cessation outcomes are heterogeneous, and factors associated with these differences are not fully understood. We examined longitudinal smoking trajectories across distinct smoking profiles and evaluated whether early craving and affective symptom changes were associated with verified abstinence. Participants in this observational cohort were classified as dependence-predominant or...
Revista Brasileira de Psiquiatria
July 7, 2026
Alberto Souza Sá Filho, James Oluwagbamigbe Fajemiroye, Antonio Egidio Nardi et al.
Few topics in contemporary psychiatry generate as much fascination, hope, and discomfort as the therapeutic use of psychedelics.For some, they represent a long-awaited disruption in the treatment of depression, a field in which many patients still experience partial response, relapse, or treatment resistance despite decades of
Revista Brasileira de Psiquiatria
May 1, 2026
Marcelo Pinheiro Machado Adelino, Julia Diniz Grossi, Marcel Vella Nunes et al.
To synthesize evidence on pharmacological treatments for major depressive disorder (MDD) to inform updated Brazilian clinical guidelines. This overview included systematic reviews and meta-analyses published in the last 10 years, identified through MEDLINE, Cochrane Library, and SciELO. Eligible studies involved adults with MDD receiving pharmacological interventions. Risk of bias was assessed...
Revista Brasileira de Psiquiatria
2026
Eduardo Aliende Perin, Nelson Carvas, Vinicius Tassoni Civile et al.
To evaluate the efficacy of mindfulness-based interventions for adults with obsessivecompulsive disorder. A systematic review and meta-analysis were conducted according to Cochrane Handbook guidelines. Two independent reviewers selected randomized controlled trials (RCTs) comparing mindfulness-based interventions with active control interventions, including cognitive/behavioral techniques and...
Revista Brasileira de Psiquiatria
September 29, 2025
Xiaotong Wang, Tao Huang, H. Lei et al.
Objective: To investigate, using functional magnetic resonance imaging (fMRI) techniques, the immediate and sustained effects of acupuncture on functional connectivity (FC) within the default mode network (DMN) and external FC. Methods: Thirty healthy participants received acupuncture needle stimulation at Baihui (GV20) and Yintang (GV29) and underwent resting-state fMRI scans in three phases:...
Revista Brasileira de Psiquiatria
2025
Wagner Farid Gattaz, Marianna de Abreu Costa, Angélica Salatino-Oliveira et al.
There has been a call for neuroscientific studies of spiritual experiences due to their global prevalence, significant impact, and importance for understanding the mind-brain problem. Mediumship is a spiritual experience where individuals claim to communicate with or be influenced by deceased persons or non-material entities. We assessed whether mediums carry specific genetic alterations. We...
Revista Brasileira de Psiquiatria
May 10, 2021
M. Gillman
I welcome the excellent paper by Guimarães et al. which extends research on nitrous oxide (N2O) in neuropsychiatry – a neglected field, since our initial work in 1982 and then 1985 indicating that low, anxiolytic, and non-anaesthetic doses of N2O ameliorate depression. 3 Research has demonstrated that N2O, at subanaesthetic concentrations acts on opioid receptors. We therefore concluded that...
Revista Brasileira de Psiquiatria
2021
Alvaro V Jardim, Dora V Jardim, Bruno Rasmussen Chaves et al.
54 citations
To conduct Brazil's first clinical trial employing 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder (PTSD), given its high prevalence resulting from epidemic violence. Of 60 volunteers, four matched the inclusion & exclusion criteria. Three patients with PTSD secondary to sexual abuse (diagnosed by the Structured Clinical Interview for DSM-IV...
Revista Brasileira de Psiquiatria
February 1, 2018
Alexander Moreira-Almeida, Saulo de F Araujo, C Robert Cloninger
Objective: The mind-brain problem (MBP) has marked implications for psychiatry, but has been poorly discussed in the psychiatric literature. This paper evaluates the presentation of the MBP in the three leading general psychiatry journals during the last 20 years. Methods: Systematic review of articles on the MBP published in the three general psychiatry journals with the highest impact factor...
Revista Brasileira de Psiquiatria
2017
Letícia O Alminhana, Miguel Farias, Gordon Claridge et al.
It is unclear why some individuals reporting psychotic experiences have balanced lives while others go on to develop mental health problems. The objective of this study was to test if the personality traits of harm avoidance, self-directedness, and self-transcendence can be used as criteria to differentiate healthy from unhealthy schizotypal individuals. We interviewed 115 participants who...
Revista Brasileira de Psiquiatria
May 1, 2011
Alexander Moreira-Almeida, Etzel Cardeña
To review research articles in psychiatry and psychology involving Latin American populations and/or produced by Latin American scholars to investigate the differential diagnosis between spiritual/anomalous experiences and mental disorders in order to contribute to the validity of the International Classification of Diseases towards its 11th edition in this area. We searched electronic...
Revista Brasileira de Psiquiatria
September 1, 2010
Ana Claudia Rodrigues de Cerqueira, Antonio Egidio Nardi
Experiência fora do corpo como um possível sintoma de transtorno de pânico Out-of-body experience as a possible symptom of panic disorderCaro Editor, Durante uma experiência fora do corpo (EFC) uma pessoa tem a sensação de que o "eu" está localizado fora dos limites do corpo físico e elevado de sua perspectiva visuoespacial 1 .Relatamos o caso de uma paciente que apresentou EFC como um possível...
Revista Brasileira de Psiquiatria
September 1, 2009
Emérita Sátiro Opaleye, Ana Regina Noto, Zila van der Meer Sanchez et al.
OBJECTIVE: To describe the recreational use of benzydamine, an anti-inflammatory drug, among street youth in Brazil. METHOD: Design: a descriptive, cross sectional survey. Setting: 93 welfare services for the street youth in 27 Brazilian capitals. Participants: 2807 street youth, 10 to 18 years old. Main outcome measures: demographic characteristics, drug use pattern (lifetime use, use in the...
Revista Brasileira de Psiquiatria
September 2009
Lara C Assis, Gislaine T Rezin, Clarissa M Comim et al.
Clinical findings suggest that ketamine may be used for the treatment of major depression. The present study aimed to compare behavioral effects and brain Creatine kinase activity in specific brain regions after administration of ketamine and imipramine in rats. Rats were acutely given ketamine or imipramine and antidepressant-like activity was assessed by the forced swimming test; Creatine...
Revista Brasileira de Psiquiatria
September 1, 2008
L. Caixeta
Some patients with schizophrenia present a related phenomenon in which they believe their limbs are under the control of an alien force (motor passivity). 5 There are some attempts to elucidate the nature and mechanism of passivity phenomena (experiences that one's conscious actions or thoughts have not been 'willed' by oneself) wich include the dysfunction of an internal self-monitoring system...
Revista Brasileira de Psiquiatria
December 1, 2006
G. Ribas
This text reviews the generic aspects of the central nervous system evolutionary development, emphasizing the developmental features of the brain structures related with behavior and with the cognitive functions that finally characterized the human being. Over the limbic structures that with the advent of mammals were developed on the top of the primitive nervous system of their ancestrals, the...
Revista Brasileira de Psiquiatria
June 1, 2006
A. Zuardi
Cannabis as a medicine was used before the Christian era in Asia, mainly in India. The introduction of cannabis in the Western medicine occurred in the midst of the 19th century, reaching the climax in the last decade of that century, with the availability and usage of cannabis extracts or tinctures. In the first decades of the 20th century, the Western medical use of cannabis significantly...
Revista Brasileira de Psiquiatria
September 2005
Sanjay J. Mathew, Kathryn Keegan, Lisa Smith
Recent evidence suggests that critical molecules in neurotrophic signaling cascades are long-term targets for currently available monoaminergic antidepressants. As chronic and severe mood disorders are characterized by impairments in neuronal resilience, pharmacological strategies that subserve a neuroprotective function might alter disorder pathophysiology and modify disease progression....
Revista Brasileira de Psiquiatria
March 2003
Stella Pereira De Almeida, Maria Teresa Araujo Silva
As there are no studies about the use of ecstasy in Brazil, our aim was to identify the effects and patterns of use of this substance among users in the city of São Paulo. Subjects were recruited through the snowball technique. Fifty-two subjects of both genders who had been using ecstasy frequently and recently were interviewed. The instrument was a self-reported and anonymous questionnaire....