The Open Field Test situation is reported to produce autonomic nervous system reactivity determined emotional freezing and defecation (1, 2), cortical excitation determined rearing activity (3), and corpus striatum activity determined stereotyped ambulation (4, 5). Thus autonomic depressant drugs reduce emotional freezing (6), cortical excitant drugs augment rearing (7, 8), and hallucinatory...
OUT ON A (PHANTOM) LIMB VARIATIONS ON THE THEME: STABILITY OF BODY IMAGE AND THE GOLDEN SECTION And man created God in his own body image. ROLAND FISCHER* Psychodysleptic Drug-inducedInterference with Readaptation to Distortions It is by now well known that wearing prism spectacles results in a variety ofperceptual distortions which, however, gradually disappear within a period oftime [i, 2,...
Contrast effects in an experiment involving no-drug, placebo, and seven drugs were postulated on the basis of Helson's adaptation level theory. For 250 male opiate addicts, it was expected and found that general subjective experiences peculiar to drugs were smaller for no-drug or placebo conditions when these conditions were administered after rather than before potent drugs such as morphine or...
LSD‐25, psilocybin and JB‐329 reduced the noradrenaline content of the rat hypothalamus. All three drugs affected the acquisition of a conditioned avoidance response, LSD‐25 and psilocybin retarding and JB‐329 enhancing the acquisition. With the exception of JB‐329, doses affecting the acquisition of a conditioned avoidance response were lower than those required to decide hypothalamic...
A synthetic isomer of tetrahydrocannabinol (1‐Δ'‐3,4‐transtetrahydrocannabinol), believed to be identical to the most active naturally occurring THC, was compared with a semisynthetic THC‐like compound, synhexyl. Sixteen volunteer subiects received THC in doses ranging from 341 to 946 p.g per kilo gram (median 581). Thirteen subjects received synhexyl in doses ranging from 633 to 2,666 µg per...
The author presents background about the growth of the psychedelic drug culture among adolescents, concentrating on the implications of the patterns of use of a major psychedelic drug, LSD, for future human development. Three areas of consequence are delineated: (1) the vulnerability of many persons who use LSD to marked panic states and psychoses, (2) the diversion of those in their middle and...
MUCH PUBLICITY in the national press, most of it adverse in the past two years, has been attached to lyseric acid diethylamide (L.S.D.25) and, therefore, it seems essential to review cases and publish the findings about the results of treatment with this drug. It would appear that in the British Isles only about 25 psychiatrists, including the author, have been enquiring into the uses and...
Abstract Various ultraviolet, infrared, and TLC procedures are described for the separation and identification of hallucinogenic drugs. Specific methods for LSD, DMT, and psilocybin are also presented, along with general background information for the hallucinogenic drugs.
S ummary In 45 normal subjects changes in the horizontal eye movements following the administration of psychotropic drugs have been studied. 1. Following the administration of amobarbital (250 mg, i.v.) and chlorpromazine (1.0mg/kg, i.m.), rapid eye movements (R) decreased gradually until they disappeared altogether. 2. LSD 25 (0.5 or 1.0γ/kg, i.m.) produced increase of R in 80% and markedly...
SIMPLE INDOLE derivatives like the alkylated tryptamines, N,N-dimethyltryptamine (DMT) and N,N-diethyltryptamine (DET), produce psychotogenic-like symptoms similar to lysergic acid diethyemide (LSD) and mescaline.1-4 One of the important metabolic pathways of DET has been shown to be by 6-hydroxylation.5The known metabolic pathways of DET are summarized in Fig 1. Other investigators have...