EFFECTS OF PSYCHOTROPIC DRUGS UPON THE EYE MOVEMENTS WITH CLOSED EYES
Y Shimazono, Katsumi Ando, Takashi Tanaka, Minoru Hayashi, Sayuri Sakamoto, Tomoya Eguchi, Hiroyuki Nakamura, Hiroyuki Kamiya
Psychiatry and Clinical Neurosciences June 1, 1967 DOI: 10.1111/j.1440-1819.1967.tb00080.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 45 |
| Population | Normal subjects |
| Interventions | Amobarbital Chlorpromazine LSD 25 Psilocybin Methamphetamine Epinephrine |
| Dose | 250 mg, i.v. for amobarbital; 1.0 mg/kg, i.m. for chlorpromazine; 0.5 or 1.0 γ/kg, i.m. for LSD 25; 3 mg, i.m. for psilocybin; 9 mg, s.c. for methamphetamine; 0.005–0.01 mg/kg, s.c. for epinephrine |
| Topics | Psilocybin |
| Keywords | Chlorpromazine Euphoriant Methamphetamine Eye movement Anesthesia |
| Citations | 4 |
| Key findings | LSD-25 and psilocybin produce large, slow pendular eye movements, especially in euphoric subjects, while amobarbital and chlorpromazine eliminate rapid eye movements. |
Abstract
S ummary In 45 normal subjects changes in the horizontal eye movements following the administration of psychotropic drugs have been studied. 1. Following the administration of amobarbital (250 mg, i.v.) and chlorpromazine (1.0mg/kg, i.m.), rapid eye movements (R) decreased gradually until they disappeared altogether. 2. LSD 25 (0.5 or 1.0γ/kg, i.m.) produced increase of R in 80% and markedly increased incidence and amplitude of slow movements (S) in about a half of the subjects. These large, slow pendular movements appeared fairly continuously and rhythmically in the subjects exhibiting mainly euphoria, disinhibition and ecstasy. 3. Following the administration of psilocybin (3mg, i.m.), similar pendular movements could also appear, but the duration of each slow movement tended to be longer. 4. Methamphetamine (9mg, s.c.) and epinephrine (0.005–0.01 mg/kg, s.c.) decreased S and increased R, but later than 20 minutes after the injection of epinephrine S appeared transiently. 5. The mechanism of action of the substances on the development of the different groups of the eye movements were discussed on the basis of these data. LSD 25 and psilocybin offered by Sandoz Pharmaceuticals Co., Ltd. were used in the above studies.
Comparable studies
Other experimental studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Healthy human volunteers | 1998 | Experimental study | |
| Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin Participants in controlled laboratory experiments receiving a moderate to high oral... | 2015 | Validation study using pooled data from five laboratory experiments | n = 184 |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer Participants with cancer-related psychiatric distress who completed a parent randomized... | 2020 | Long-term within-subjects follow-up analysis | n = 15 |
| Enzymatic Synthesis of Psilocybin | 2017 | Laboratory study |