December 2, 2025
Leor Roseman
The recent mainstreaming of psychedelics has distanced itself from the countercultural image of the past, yet the question of whether psychedelics are political remains pressing. What happens when psychedelics meet politics?On one hand lies the politics of the unitive mystical experience: harmony, beyond good & evil, beyond space & time, and with love to all. Studying ayahuasca groups of...
Emerging Trends in Drugs, Addictions, and Health
December 1, 2025
Roberto Cavallaro, A. Carollo, O. Corazza et al.
Introduction Psychedelics have long been used in spiritual and medicinal contexts. Recently, growing scientific interest, driven by preliminary evidence of clinical efficacy, has renewed focus on their therapeutic potential. This study explores the historical evolution of clinical psychedelic research using a scientometric approach. Methods We downloaded 1664 documents from Scopus, covering the...
Emerging Trends in Drugs, Addictions, and Health
December 1, 2025
Federico Seragnoli
Introduction Psychedelic Assisted Psychotherapy (PAP) has been legal in Switzerland since 2014 under supervised exceptional medical use with MDMA, LSD and Psilocybin with case by case authorisations delivered from the Federal Office of Public Health. In particular, since 2021, we have implemented a clinical activity at Geneva University Hospital (HUG) for treatment resistant patients using LSD...
SUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice
December 1, 2025
Johannes Klaus, Fritz Schneider, Rena Schaletzky et al.
Abstract: Background: Psychedelic-assisted therapy is increasingly being explored as potential treatment for substance use disorders (SUDs). While multiple systematic reviews and meta-analyses have examined this topic, the efficacy, methodological quality, and overlap of the existing evidence base remain unclear. Methods: We conducted an umbrella review of systematic reviews and meta-analyses...
SUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice
December 1, 2025
Dario Jalilzadeh Masah, Derin Marbin, Tomislav Majić
1 citation
Abstract: Aims: Symptoms of depersonalization (DP) and derealization (DR) are commonly reported during the acute effects of classic psychedelics. In some individuals, these symptoms persist, resulting in depersonalization-derealization disorder (DDD), associated with distress and help-seeking behavior. This case series seeks to underscore some of the diagnostic challenges and treatment...
SUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice
December 1, 2025
Alexander Wopfner, Thilo Beck, Louise Penzenstadler
Zusammenfassung: Hintergrund: Die Schweizerische Gesellschaft für Suchtmedizin (SSAM) setzt sich für die wissenschaftlich fundierte und patientenorientierte Behandlung von Suchterkrankungen ein. Position: Angesichts der jüngsten wissenschaftlichen Erkenntnisse und internationaler Entwicklungen beurteilt die SSAM Psychedelika assistierte Psychotherapie (PAT) mit klassischen Psychedelika wie LSD...
Research Square
December 1, 2025
Albert Buchard, Federico Seragnoli, Michel Sabé et al.
preprint
Abstract Early maladaptive schemas (EMS) are highly prevalent in patients seeking psychedelic-assisted psychotherapy and correlate strongly with baseline depression and anxiety. This study characterized EMS in 192 adults and longitudinally followed 74 patients receiving psilocybin- or LSD-assisted therapy. We found that baseline schema burden, particularly related to failure and defectiveness,...
Philosophical Psychology
November 30, 2025
Julian Kiverstein, Hüseyin Beyköylü, Michiel van Elk
3 citations
Psychedelic research has shown that the effects of serotonergic substances, such as psilocybin and LSD, are strongly influenced by the interaction of substance, set, and setting. Mystical-type experiences, often induced by psychedelics, are not solely driven by pharmacological mechanisms but emerge from a dynamic interplay between the psychological state (set), external environment (setting),...
bioRxiv
November 26, 2025
Rui Dai, Rodrigo Cofré, Christopher Timmermann et al.
preprint
The mechanism of psychedelic drug action is a dynamic area of neuroscience, with two major lines of investigation: (1) laboratory studies at the molecular and cellular level, and (2) human neuroimaging studies of functional brain networks. Despite considerable progress, there remains insufficient understanding of the link between molecular/cellular substrates of psychedelics and the whole-brain...
Journal of Psychiatric Research
November 26, 2025
Michael van Ameringen, Vidhi Patel, Beth Patterson et al.
The etiology of OCD is complex and appears to involve multiple biological pathways. Imbalances in central serotonin, dopamine, and glutamate activities are widely thought to play a causative role. Despite strong evidence supporting first-line OCD pharmacotherapies, approximately 40-60 % of OCD patients remain unresponsive and are considered treatment resistant (TR). Although a range of agents...