Drug Testing and Analysis
May 13, 2019
Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal et al.
72 citations
Abstract The psychedelic properties of lysergic acid diethylamide (LSD) have captured the imagination of researchers for many years and its rediscovery as an important research tool is evidenced by its clinical use within neuroscientific and therapeutic settings. At the same time, a number of novel LSD analogs have recently emerged as recreational drugs, which makes it necessary to study their...
JURNAL KEPERAWATAN
May 2, 2019
Rahel A. Kululu, Esrom Kanine, Andi Buanasari
Abstrack: The use of narcotics, psychotropic and other addictive substances hasbeen used up to adolescents. Adolescents use drugs because it has many motivation, motivation arising from within themselves as well as the motivation that arise because of the encouragement from the outside.The use of this drug can also be seen in Johnson's behavioral system model by reviewing with seven subsystems....
Pharmacology & Therapeutics
May 1, 2019
Matthew W Johnson, Peter S. Hendricks, Frederick S. Barrett et al.
520 citations
The purpose of this paper is to provide an integrative review and offer novel insights regarding human research with classic psychedelics (classic hallucinogens), which are serotonin 2A receptor (5-HT2AR) agonists such as lysergic acid diethylamide (LSD), mescaline, and psilocybin. Classic psychedelics have been administered as sacraments since ancient times. They were of prominent interest...
PLoS One
April 23, 2019
Roland R. Griffiths, Ethan Hurwitz, Alan K. Davis et al.
249 citations
Naturally occurring and psychedelic drug-occasioned experiences interpreted as personal encounters with God are well described but have not been systematically compared. In this study, five groups of individuals participated in an online survey with detailed questions characterizing the subjective phenomena, interpretation, and persisting changes attributed to their single most memorable God...
Neurotoxicity Research
April 15, 2019
Monika Herian, Adam Wojtas, Katarzyna Kamińska et al.
44 citations
NBOMes are N-benzylmethoxy derivatives of the 2C family hallucinogens. 4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe) is one of the commonly used illicit drugs. It exhibits high binding affinity for 5-HT 2A/C and 5-HT 1A serotonin receptors. Activation of 5-HT 2A receptor induces head-twitch response (HTR) in rodents, a behavioral marker of hallucinogen effect in humans....
The FASEB Journal
April 1, 2019
Meghan Hibicke, Alexus N. Landry, Zoe K. Talman et al.
7 citations
Introduction Psilocybin has recently demonstrated profound efficacy to alleviate depression and anxiety in several clinical trials and has received Breakthrough Status by the FDA. Symptomatic relief after only one or two therapeutic treatments last for at least several months in the vast majority of individuals. It is unclear whether the persistent antidepressant and anxiolytic effects are a...
British Journal of Clinical Pharmacology
March 19, 2019
Friederike Holze, Urs Duthaler, Patrick Vizeli et al.
72 citations
Aims The aim of the present study was to characterize the pharmacokinetics and exposure–subjective response relationship of a novel oral solution of lysergic acid diethylamide (LSD) that was developed for clinical use in research and patients. Method LSD (100 μg) was administered in 27 healthy subjects using a placebo‐controlled, double‐blind, cross‐over design. Plasma levels of LSD, nor‐LSD,...
Journal of Psychoactive Drugs
March 15, 2019
Alexander Trope, B. Anderson, Andrew R. Hooker et al.
113 citations
Contemporary research with classic psychedelic drugs (e.g., lysergic acid diethylamide (LSD) and psilocybin) is indebted to the twentieth-century researchers and clinicians who generated valuable clinical knowledge of these substances through experimentation. Several recent reviews that highlight the contributions of this early literature have focused on psychedelic-assisted individual...
Journal of Psychoactive Drugs
March 15, 2019
Lisa Jerome, Brad Burge, Richard Doblin et al.
87 citations
Psychedelic plants and fungi have been used in indigenous medicinal traditions for millennia. Modern psychedelic research began when Albert Hofmann first synthesized lysergic acid diethylamide (LSD-25) in 1938. Five years later, became the first person to ingest LSD. Hofmann was unaware of the significance of his actions, and the effects they would set in motion. After a burgeoning period of...
Journal of Psychoactive Drugs
March 6, 2019
Jacob S. Aday, Emily K. Bloesch, Christopher C. Davoli
19 citations
During the 1950s and 1960s, there was a tremendous surge in research into the effects of psychedelic drugs. When discussing this period of research, the discovery of the psychoactive properties of LSD in 1943 is often presented as the main, and sometimes only, driving force of the boom in research. This "Great Person," or "Great Chemical," historiographical lens fails to acknowledge other...
Journal of Substance Use
March 4, 2019
Tamonud Modak, Roshan Bhad, Ravindra Rao
7 citations
Lysergic acid diethylamide (LSD) is a semisynthetic compound with strong psychoactive properties. LSD has been used as an adjunct to psychotherapy and treatment for various forms of drug addiction as well as a drug of abuse by the hippie counterculture movement of the 1960s. The literature regarding LSD is limited, and it has hardly been studied after it was banned in the 1970s. LSD is known to...
Journal of Psychedelic Studies
March 1, 2019
Ronald Lee Zigler
In a letter to Humphrey Osmond in 1953, Aldous Huxley speculated about a “new system” of education in which psychedelics may play a part “by making it possible for young people to ‘taste and see’ what they have learned about at second hand, or directly but at a lower level of intensity, in the writings of the religious, or the works of poets, painters and musicians.” In 1968, the author...
The Journal of Nervous and Mental Disease
February 26, 2019
Pedro Ruiz
11 citations
Clinical Professor Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston, TX.
Cureus
February 14, 2019
Muhannad Kurtom, Ashley Henning, Eduardo D. Espiridion
This is a case report of hallucinogen-persisting perception disorder in a 21-year-old man. Hallucinogen-persisting perception disorder, or acute hallucinogen-induced psychosis, is a rare disorder characterized by the presence of flashbacks of visual hallucinations as a result of previous hallucinogenic drug use. There is no standard of treatment, and management involves a combination of...
Psychopharmacology
February 14, 2019
Adam L. Halberstadt, Landon M. Klein, Muhammad Chatha et al.
25 citations
Rationale The lysergamide lysergic acid diethylamide (LSD) is a prototypical classical hallucinogen with remarkably high potency. LSD remains a popular recreational drug but is also becoming an important research tool for medical and neuroscience studies. Recently, several lysergamides that are close structural analogs of LSD have been sold as recreational drugs, which suggests that further...
bioRxiv Preprint Server
January 28, 2019
Thomas Pokorny, Patricia Duerler, Erich Seifritz et al.
2 citations
preprint
Psychiatric and neurodegenerative illnesses are characterized by cognitive impairments, in particular deficits in working memory, decision making, and executive functions including cognitive flexibility. However, the neuropharmacology of these cognitive functions is poorly understood. The serotonin (5-HT) 2A receptor might be a promising candidate for the modulation of cognitive processes....
Proceedings of the National Academy of Sciences
January 28, 2019
Katrin H. Preller, Adeel Razi, Peter Zeidman et al.
303 citations
Psychedelics exert unique effects on human consciousness. The thalamic filter model suggests that core effects of psychedelics may result from gating deficits, based on a disintegration of information processing within cortico-striato-thalamo-cortical (CSTC) feedback loops. To test this hypothesis, we characterized changes in directed (effective) connectivity between selected CTSC regions after...
Revista Texto Poético
January 25, 2019
Fernanda Vivacqua de Souza Galvão Boarin, Alexandre Graça Faria
O presente artigo apresenta uma leitura do relato Experiência com LSD, do poeta, cronista e tradutor brasileiro Paulo Mendes Campos, escrito originalmente em 1962. Para tanto, recorre-se às relações dialógicas encontradas no texto, a exemplo de As portas da percepção: e céu e inferno (1954), de Aldous Huxley, tendo como objetivo compreender não apenas as formulações de Campos sobre a...
bioRxiv (Cold Spring Harbor Laboratory)
January 11, 2019
Tf. Varley, Robin Carhart-Harris, Leor Roseman et al.
8 citations
preprint
Abstract Psychedelic drugs, such as psilocybin and LSD, represent unique tools for researchers in-vestigating the neural origins of consciousness. Currently, the most compelling theories of how psychedelics exert their effects is by increasing the complexity of brain activity and moving the system towards a critical point between order and disorder, creating more dynamic and complex patterns of...
Journal of Clinical & Experimental Dermatology Research
2019
Yeng-Chan Sik, K. Hussain, C. Soon
Erythema multiforme major (EMM) is a severe hypersensitivity skin reaction that is potentially life threatening. We present a case report of a gentleman who presented with EMM induced by Lysergic acid diethylamide. The case aims to raise awareness and highlights the importance of taking a comprehensive drug history including recreational drug use. This is especially important in the face of...