Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
December 31, 2023
Francisco Madrid-Gambin, David Fabregat-Safont, Alex Gomez-Gomez et al.
12 citations
Psychedelics are classical hallucinogen drugs that induce a marked altered state of consciousness. In recent years, there has been renewed attention to the possible use of classical psychedelics for the treatment of certain mental health disorders. However, further investigation to better understand their biological effects in humans, their mechanism of action, and their metabolism in humans is...
December 26, 2023
Burton J. Tabaac, Kenneth Shinozuka, Alejandro Arenas et al.
preprint
Background: Psychedelic drugs have recently emerged as plausibly effective pharmacological agents for the management of depression, anxiety, and other neuropsychiatric conditions, including conditions that have not benefited from prior interventions. The latter half of the twentieth century marked a revolution in the treatment of depression, anxiety, and psychosis, exemplified by the...
Research, Society and Development
December 13, 2023
Caíque Gois Cardoso, Milena de Barros Viana
2 citations
Introduction: With the progressive advancement of clinical and experimental trials aimed at investigating the pharmacotherapeutic potential of psychedelic substances, there is also the development of other conceptions of use, not only for the treatment of psychiatric disorders, but also for the improvement of emotional/cognitive functions. Objective: The present study is a systematic review of...
HAL (Le Centre pour la Communication Scientifique Directe)
December 1, 2023
Zoë Dubus, Elise Grandgeorge, Vincent Verroust
International audience
Journal of Military, Veteran and Family Health
December 1, 2023
Erika Dyck, Gregory P. Marchildon
LAY SUMMARY The historical relationship between psychedelic drugs and the military has often been characterized in terms of drug misuse or the connection between drugs like d-lysergic acid diethylamide (LSD) or psilocybin (magic mushrooms) contributing to anti-war sentiments. Recent clinical evidence, however, suggests these cultural associations may be overshadowing the potential for...
Journal of Military, Veteran and Family Health
December 1, 2023
Emmanuelle A. D. Schindler, Jason J. Sico
LAY SUMMARY Patients with headache disorders, such as migraine or cluster headache, often have poor quality of life and can be disabled by their condition. Military members and Veterans have a high risk of developing a headache disorder, particularly because they are also at risk for brain injury through head trauma. New headache treatments are needed, because the available treatments may not...
Neuropsychopharmacology
December 1, 2023
Isabelle Straumann, Laura Ley, Friederike Holze et al.
41 citations
There is renewed interest in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. Although acute subjective effects of LSD are mostly positive, negative subjective effects, including anxiety, may occur. The induction of overall positive acute subjective effects is desired in psychedelic-assisted therapy because positive acute experiences are associated with greater...
Neuroimage
December 1, 2023
Stefano Delli Pizzi, Piero Chiacchiaretta, Carlo Sestieri et al.
27 citations
The role of the thalamus in mediating the effects of lysergic acid diethylamide (LSD) was recently proposed in a model of communication and corroborated by imaging studies. However, a detailed analysis of LSD effects on nuclei-resolved thalamocortical connectivity is still missing. Here, in a group of healthy volunteers, we evaluated whether LSD intake alters the thalamocortical coupling in a...
Pharmacological Reports
December 1, 2023
Adam Wojtas
10 citations
Since its emergence in the 1960s, the serotonergic theory of depression bore fruit in the discovery of a plethora of antidepressant drugs affecting the lives of millions of patients. While crucial in the history of drug development, recent studies undermine the effectiveness of currently used antidepressant drugs in comparison to placebo, emphasizing the long time it takes to initiate the...
CNS Drugs
December 1, 2023
Niloufar Pouyan, Farnaz Younesi Sisi, Alireza Kargar et al.
12 citations
The renewed interest in psychedelic research provides growing evidence of potentially unique effects on various aspects of reward processing systems. Using the Research Domain Criteria (RDoC) framework, as proposed by the National Institute of Mental Health, we aim to synthesize the existing literature concerning the impact of lysergic acid diethylamide (LSD) on the RDoC's Positive Valence...
Chemical Reviews
November 30, 2023
Wenwen Duan, Dongmei Cao, Sheng Wang et al.
62 citations
Psychedelics make up a group of psychoactive compounds that induce hallucinogenic effects by activating the serotonin 2A receptor (5-HT2AR). Clinical trials have demonstrated the traditional psychedelic substances like psilocybin as a class of rapid-acting and long-lasting antidepressants. However, there is a pressing need for rationally designed 5-HT2AR agonists that possess optimal...
The MIT Press eBooks
November 21, 2023
Ross Crockford
1 citation
Hausner originally doubted that she could be helped.But as he listened to a recording of Hana's third LSD session, he saw some hope."The most pronounced aspect of this session is her archetypal regression into the realm of antiquity and to the very beginnings of humanity," Hausner later wrote. 1 "Hana is beginning to formulate a new attitude toward death and eternity."Over the next six months,...
The MIT Press eBooks
November 21, 2023
Stephen Snelders
1 citation
Dutch psychedelic history had its own characteristics. In psychiatry, LSD therapy was used for the management of the traumas of World War II; in Dutch society, overlapping groups of activists and psychedelics users were involved in a playful transformation of society into a “Magical Center”; and in economics, the Netherlands became a key player in the illegal production and distribution of LSD...
The MIT Press eBooks
November 21, 2023
Magaly Tornay
From its very beginning, when a drop of LSD-25 permeated the skin of Albert Hofmann’s fingertips in Sandoz laboratories in 1943, the substance has been a negotiator of boundaries. Symbolized by Hofmann’s bicycle ride, the first intentional trip with the mysterious drug, it has since stood for journeys into unknown realms, expanding limits, and subverting authority. In its early history,...
Frontiers in Psychiatry
November 21, 2023
Peter Wipf, Nikhil R. Tasker, Ethan J. Pazur
7 citations
In contrast to well established psychedelics such as lysergic acid diethylamide (LSD) and psilocybin, ergot alkaloids of the clavine subclass have not been thoroughly investigated, in spite of their broad occurrence in nature and their well-established potent physiological effects. This study presents the current knowledge on the biological properties of clavine alkaloids, draws comparisons to...
Journal of Psychopharmacology
November 20, 2023
Andreas Halman, Geraldine Kong, Jerome Sarris et al.
42 citations
Classic psychedelics, including lysergic acid diethylamide (LSD), psilocybin, mescaline, N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), are potent psychoactive substances that have been studied for their physiological and psychological effects. However, our understanding of the potential interactions and outcomes when using these substances in combination with...
European Psychiatry
November 17, 2023
L. Silva, L. Bravo
1 citation
Introduction Lysergic acid diethylamide (LSD) a semi synthetic hallucinogen, was first synthetized by Albert Hofmann in 1938 and its psychological properties were not discovered until 1943. There was a brief renaissance of its use in psychiatry, specifically in assisted psychotherapy for the treatment of alcoholism, neurosis and psychosomatic disorders. However, research with LSD and others...
Journal of Psychopharmacology
November 16, 2023
Oliver Rumle Hovmand, Emil Deleuran Poulsen, Sidse Arnfred
31 citations
Background: The classical psychedelics psilocybin, peyote, ayahuasca/ N, N-dimethyltryptamine, and lysergic acid diethylamide can temporarily produce altered states of consciousness, characterized by changes in sensory perception, thought, mood, and the sense of self-reality and meaning. It is important to have reliable instruments for quantifying these altered states in trials, due to a...
Frontiers in Psychiatry
November 13, 2023
Tor-Morten Kvam, Malin V. Uthaug, Kristoffer A A Andersen et al.
21 citations
Objective In recent years, there has been a renewed interest in investigating the use of classic psychedelics such as psilocybin and lysergic acid diethylamide (LSD) in the treatment of mental disorders and substance use disorders. However, knowledge about the epidemiology of classic psychedelics in the Nordic countries is limited. Methods We recruited adult, Norwegian participants who have had...
Journal of Sociology, Psychology & Religious Studies
November 6, 2023
Sarah Naher, Sarah Naher
1 citation
Mental illnesses pose social, economic, and health burdens worldwide. The increasing health burden and mental diseases pose the need for investigating other potential medications. The present review focuses on psychedelic medications. The Patient/Participant, Intervention, Outcomes, and Studies ([PICOS) protocol and the Preferred Reporting Items for Systematic Reviews (PRISMA) checklist guided...