Brazilian Journal of Implantology and Health Sciences
August 26, 2026
Kristen Garcia Costa, Gabriela Sensi Santhiago, Daniel Cardoso Madeira et al.
Introdução: O transtorno depressivo maior constitui uma importante causa de incapacidade e comprometimento da qualidade de vida. Entre os pacientes que não apresentam resposta adequada a tratamentos antidepressivos convencionais, destaca-se a depressão resistente ao tratamento, para a qual permanecem limitações terapêuticas relevantes. Nesse contexto, a cetamina e a esketamina surgiram como...
Biomolecules
August 24, 2026
Agnieszka Pałucha-Poniewiera
The use of animal models to study mental illnesses, such as depression, requires proper standardization and extensive expertise. Achieving good construct, face, and predictive validity in depression models is quite challenging. Currently, only a few environmental models, mostly based on chronic stress, and a limited number of genetic models fulfill these criteria. In the quest for new...
International Health Sciences Review
August 18, 2026
Samuel Cândido Freres, Marco Antonio Franco Cançado, Aline Ferreira Catrolio et al.
Treatment-resistant depression (TRD) represents one of the most complex forms of major depressive disorder, characterized by the persistence of clinically significant symptoms despite the performance of appropriate therapeutic interventions. This condition is associated with a worse prognosis, higher risk of recurrence, functional impairment, increased morbidity and mortality, and high...
arXiv Preprint Archive
August 16, 2026
Ryota Kanai
preprint
Global workspace theory explains conscious access as the broadcasting of selected information to the rest of the network, but it lacks a formal criterion for identifying the mechanism that enables this access. We propose that a global workspace is a mediator, namely, a subnetwork that receives activity from distributed systems, transforms it through internal modes, and returns differentiated...
Psychedelics
August 14, 2026
Robert McGrath, Everett B. Sackett
Artificial intelligence is entering psychedelic-assisted therapy (PaT) through at least two channels, pre-licensure facilitator training simulators and in-session administrative tools. This arrival is occurring in a context where relational factors, those interpersonal considerations between patients and providers, are not incidental but highly impactful. A 2025 international Delphi consensus...
Frontiers in Physiology
August 10, 2026
Dan Yu, Ye Liao, Jie Li et al.
Propofol, one of the most widely used intravenous anesthetics, is undergoing a transformative identity shift from a purely surgical agent to a potential therapeutic tool for neuropsychiatric disorders. This review synthesizes current evidence on the emerging field of propofol therapeutics, with a focus on its rapid antidepressant, anti-anhedonia, and anxiolytic effects. We first examine...
Revista de Estudos Interdisciplinares
August 6, 2026
Helena Victor Leite Panadés, Isadora Queiroz Graça, Maria Fernanda Vasconcelos Mascarenhas Clementino et al.
Introduction: Treatment-resistant depression (TRD) is characterized by the persistence of depressive symptoms following at least two adequate therapeutic trials with distinct classes of antidepressants. Given the limited efficacy of the traditional monoaminergic model and the high socioeconomic and functional burden of the disease, interventions with rapid mechanisms of action have become...
JAMA Psychiatry
August 5, 2026
Michael Elliott, Olga Chernoloz
To the Editor In JAMA Psychiatry, Cubała et al. report that inhaled mebufotenin (GH001) reduced depression severity by 15.5 points more than placebo on the Montgomery-Åsberg Depression Rating Scale (MADRS) at 1 week, with 57.5% of patients achieving remission vs 0% in the placebo group. The effect size (d = −2.0) overwhelmingly surpasses those of selective serotonin reuptake inhibitors,...
Pharmacology, Biochemistry, and Behavior
August 1, 2026
Mengyang He, Zhifei Shi, Ruijie Zhan et al.
Depression is a complex mental disorder threatening global public health. Its pathophysiological mechanisms involve multidimensional dysfunctions including the emotional-cognitive circuit, Hypothalamic-Pituitary-Adrenal (HPA) axis, neurotransmitter systems and neuroplasticity. Current studies mostly analyze each system in isolation, lacking a unified integrated framework. This review proposes...
International Immunopharmacology
August 1, 2026
Jinghua Zhao, Ruxin Zhang, Jiarui Pan et al.
Depression-like behavior is closely associated with neuroinflammation. Lipopolysaccharide (LPS) can activate N-methyl-d-aspartate receptors and induce cellular pyroptosis and neuroinflammation, thereby triggering depression-like behavior in animals. The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) exerts significant antidepressant-like effects without the adverse effects associated with...