Page 354 of 449: studies 3,531 to 3,540 of 4,486, newest first. Back to the ketamine overview
September 29, 2026 Paul S. Links
Antidepresanlara ve diğer ilaçlara yanıt vermemiş komorbid majör depresyonu olan BKB hastalarında nöromodülasyonu değerlendirin. Sistematik derleme kanıtları bu vakalarda tamamlayıcı bir rolü desteklemektedir. BKB'de ketamin kullanırken, dezinhibe davranışlar ve artmış intihar düşüncesi açısından dikkatle izleyin. Olgu sunumları her ikisini de olumsuz reaksiyon olarak belgelemiştir. MDMA...
September 29, 2026 Itzchak Angel, Yoseph Caraco, Chana Sternberg et al.
Background: Ketamine, a high-affinity NMDA receptor antagonist, is used off-label for neuropathic pain but has limited clinical utility due to poor oral bioavailability, narrow therapeutic window, and dissociative effects. Ketamir-2 is a novel low-affinity, phencyclidine-site-selective NMDA antagonist (IC50 ~100 µM versus ketamine's low single-digit µM), designed to retain analgesic activity...
Translational Psychiatry September 28, 2026 Johan Saelens, Franziska Stadler, Victoria Forschauer et al.
Obsessive-compulsive disorder (OCD) is a highly debilitating and often chronic condition. A large percentage of patients do not respond to first-line treatments with selective serotonin reuptake inhibitors (SSRIs) or cognitive behavioral therapy (CBT), underscoring the need for novel therapeutic approaches. In this context, promising innovative treatments have recently emerged for OCD; these...
Zenodo (CERN European Organization for Nuclear Research) September 26, 2026 Chad Thomas preprint
This paper explains acute‑state dissociation through a bottom‑up neurobiological lens, showing how trauma conditioning, salience misrouting, and memory‑encoding shutdown create states where individuals appear responsive while evaluative and reflective systems are offline. It integrates research on autobiographical memory, substance‑induced impairment, and consent vulnerability to clarify how...
Frontiers in Psychiatry September 24, 2026 Franziska Stadler, Johan Saelens, Ioline D. Henter et al.
Background: The past few decades have seen a revived interest in psychedelic-assisted and ketamine-assisted therapy for mental health disorders, but data concerning the acute, subacute, and long-term effects of serotonergic psychedelics on cognitive functioning are scarce. This international, online study (N = 759) sought to investigate the potential acute, subacute, and long-term effects of...
Scientific Reports September 24, 2026 Giammarco di Gregorio, Basset Sophia, Harjot Manmohan et al.
Abstract Depression and anxiety affect one in five adults and vary across the lifespan; while prevalence generally declines with age until midlife, later life is marked by a re-emergence of symptoms. Although clinical trials suggest classic psychedelics (e.g., psilocybin, LSD) and non-classic psychedelics (e.g., MDMA, ketamine) may alleviate these symptoms, it remains unclear how these...
Science Advances September 23, 2026 Jinseon Yu, In Sun Choi, Gyu Hyun Kim et al.
Thalamofrontal (TF) dysconnectivity is one of the most consistent circuit-level abnormalities reported in patients with schizophrenia and is linked to deficits in short-term memory (STM). However, the biological mechanisms underlying TF weakening remain unclear. Here, we show that repeated adolescent N -methyl- d -aspartate receptor (NMDAR) antagonism produces STM deficits by impairing TF...
Quality in Sport September 17, 2026 Maciej Krzysztof Kisielewski, Natalia Fidut, Jakub Skrzypek et al.
Introduction and objective: Major depressive disorder (MDD) is a heterogeneous psychiatric condition characterized by affective, cognitive and somatic symptoms that considerably impair daily functioning. It is defined clinically by prolonged low mood, diminished interest or pleasure, and a range of associated disturbances, including changes in cognitive skills, appetite, and sleep patterns....
Cells September 17, 2026 Katarzyna Lipke, Agnieszka Piwowar
Formerly recognized as an opioid receptor, the sigma-1 receptor (σ1R) is a multifunctional chaperone protein that plays a crucial role in regulating neuronal signaling, neuroprotection, and synaptic plasticity. Increasing evidence highlights a tight functional association between the σ1R and the N-methyl-D-aspartate receptor (NMDAR), a central mediator of excitatory neurotransmission and...
Zenodo (CERN European Organization for Nuclear Research) September 13, 2026 Flávio Marco Rego da Silva preprint
The ratio R = E/|O_info| - spectral energy per unit of integrated informational structure - was proposed as a candidate outcome observable of the thermodynamics of consciousness: an energetic cost per nat of integration. We report its complete empirical genealogy across eight pre-registered studies in public datasets (Sleep-EDF, 153 nights, N=76/77; DOSE-I propofol, N=170; 62-channel ketamine,...