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DMT: all studies

Page 51 of 160: studies 501 to 510 of 1,593, newest first. Back to the DMT overview

Research

Nociception is enhanced after low doses and reduced after high doses of the serotonin receptor agonist 5-methoxy-N,N-dimethyltryptamine.

Neuroscience Letters September 1, 1980 O G Berge, K Hole, H Dahle 34 citations

The effects on pain sensitivity of intracerebroventricular injections of 5-methoxy-N,N-dimethyltryptamine were tested by the tail-flick method. Following administration of 1.6, 3.1, 6.3, 12.5 and 25 micrograms (n = 8 for each dose), tail-flick latencies were reduced by 13-24%. Fifty and 100 micrograms caused a biphasic response (hyperalgesia followed by analgesia), whereas 400 micrograms...

DOI: 10.1016/0304-3940(80)90198-6 (opens in new tab) Full text (opens in new tab)

BEHAVIOURAL CHANGES INDUCED BY N,N‐DIMETHYLTRYPTAMINE IN RODENTS

British Journal of Pharmacology May 1, 1980 P. Jenner, C.d. Marsden, C.m. Thanki 38 citations

N,N‐Dimethyltryptamine (DMT) in pargyline pretreated rodents induced a dose‐dependent behavioural syndrome consisting of hyperactivity, prostration and hindlimb abduction, mild tremor, Straub tail, retropulsion and jerking. In rats pretreated with pargyline, the behavioural syndrome induced by DMT differed from that induced by l‐tryptophan or quipazine, in the lack of forepaw treading and...

DOI: 10.1111/j.1476-5381.1980.tb10884.x (opens in new tab)

5-Methoxy-N,N-dimethyltryptamine: spinal cord and brainstem mediation of excitatory effects on acoustic startle.

Psychopharmacology 1980 M Davis, D I Astrachan, P M Gendelman et al. 39 citations

The effects of different doses (0.03, 0.06, 0.12, 0.25, 1.0, 2.0, 4.0, and 8.0 mg/kg body weight) of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) were tested on the acoustic startle reflex in rats. Beginning at 0.12 mg/kg, 5-MeODMT increased startle monotonically up to the highest dose used. 5-MeODMT still increased startle in acutely decerebrate rats or when infused directly onto the spinal...

DOI: 10.1007/BF00435302 (opens in new tab) Full text (opens in new tab)

Repeated administration of 5-methoxy-N,N-dimethyltryptamine to male rats potentiates stimulation of prolactin secretion by serotonin agonists.

European Journal of Pharmacology October 15, 1979 Miljana Simonovic, Herbert Y. Meltzer 11 citations

Repeated administration of 5-methoxy-N,N-dimethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentiated its prolactin (PRL)-releasing effect and that of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. This pretreatment schedule had no effect on PRL response to anti-dopaminergic drugs. The onset of enhanced PRL response to...

DOI: 10.1016/0014-2999(79)90310-8 (opens in new tab) Full text (opens in new tab)

Increased excretion of dimethyltryptamine and certain features of psychosis: a possible association.

Archives of General Psychiatry June 1979 R M Murray, M C Oon, R Rodnight et al.

The excretion of the hallucinogen dimethyltryptamine (DMT) and its precursor N-methyltryptamine (NMT) was studied among 74 recently admitted psychiatric patients and 19 normal persons. Both compounds were detected in 24-hour urine samples from all subjects. Dimethyltryptamine excretion was greatest in schizophrenia, mania, and "other psychosis" and tended to decline as clinical state improved....

DOI: 10.1001/archpsyc.1979.01780060034003 (opens in new tab) Full text (opens in new tab)

Naloxone enhancement of DMT and LSD-25 induced suppression of food-rewarded bar pressing behavior in the rat.

Psychopharmacology April 25, 1979 D Ruffing, B Kovacic, S Demetriou et al.

The narcotic antagonist naloxone was tested to determine its possible interaction with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained to press a bar on a fixed-ratio four schedule (FR4), i.e., every fourth press earned a reward of 0.01 ml sugar sweetened milk. LSD (0.1 mg/kg) or increasing doses of DMT (1.0, 3.2, and 10.0 mg/kg) were...

DOI: 10.1007/bf00431949 (opens in new tab) Full text (opens in new tab)

LACK OF ENHANCEMENT OF DIMETHYLTRYPTAMINE FORMATION IN RAT BRAIN AND RABBIT LUNG IN VIVO BY METHIONINE OR S‐ADENOSYLMETHIONINE

Journal of Neurochemistry October 1, 1978 Giorgio Stramentinoli, Ross J. Baldessarini

Abstract In vivo conversion of intracisternally administered [14C]tryptamine to [14C]N,N‐dimethyl‐tryptamine (DMT) in rat brain, even in the presence of an excess of substrate and methyl donor appeared to be insignificant, although enzymatically synthesized [14C]DMT was recovered readily after intracranial injection. Authenticity of [14C]DMT was demonstrated by cocrystallization with authentic...

DOI: 10.1111/j.1471-4159.1978.tb00141.x (opens in new tab)

Effects of N,N-Dimethyltryptamine (DMT) and 5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) on shock elicited fighting in rats

Pharmacology, Biochemistry, and Behavior July 1, 1978 James K. Walters, Michael H. Sheard, Michael T. Davis 18 citations

Rats were tested for shock elicited fighting under various doses of N,N-dimethyltryptamine (0.12, 0.25, 0.50, 1.0, 4.0, 8.0 mg/kg) and 5-methoxy-N,N-dimethyltryptamine (0.06, 0.12, 0.5, 2.0 mg/kg). Both drugs produced an inhibition of fighting at higher doses but no significant effects at lower doses. The effects of these drugs on shock elicited fighting, as well as on other behaviors, thus...

DOI: 10.1016/0091-3057(78)90016-3 (opens in new tab) Lysergic acid diethylamide Serotonin Hallucinogen Pharmacology +1