Repeated administration of 5-methoxy-N,N-dimethyltryptamine to male rats potentiates stimulation of prolactin secretion by serotonin agonists.
Miljana Simonovic, Herbert Y. Meltzer
European Journal of Pharmacology October 15, 1979 DOI: 10.1016/0014-2999(79)90310-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 5MeODMT quipazine N N-dimethyltryptamine |
| Dose | 5 mg/kg |
| Duration | Every 3 h for a total of 4 injections |
| Topics | 5-MeO-DMT DMT Serotonin |
| Citations | 11 |
| Key findings | Repeated administration of 5MeODMT potentiates prolactin release in response to serotonin agonists but not to anti-dopaminergic drugs, suggesting sensitization of the serotonergic mechanism. |
Abstract
Repeated administration of 5-methoxy-N,N-dimethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentiated its prolactin (PRL)-releasing effect and that of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. This pretreatment schedule had no effect on PRL response to anti-dopaminergic drugs. The onset of enhanced PRL response to serotonin agonists was gradual and appears to be due to sensitization of the serotonergic mechanism involved in the regulation of PRL secretion. The possible mechanisms underlying this phenomenon are discussed.
Comparable studies
Other preclinical and animal studies on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. Human primary monocyte-derived dendritic cells | 2014 | In vitro study | |
| Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression Adult male Sprague-Dawley rats | 2018 | Experimental study | |
| Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. Mice and rats | 2006 | Preclinical study | |
| Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors Rats and transfected fibroblasts | 1998 | Experimental study | |
| Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat Intact rats and rats depleted of monoamines with reserpine | 1985 | Experimental study |
Citations in the library
Cited by 6
- The clinical pharmacology and potential therapeutic applications of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) Journal of Neurochemistry February 12, 2022
- A narrative synthesis of research with 5-MeO-DMT. Journal of Psychopharmacology March 1, 2022
- Biphasic effect of 5-methoxy-N,N-dimethyltryptamine on rat prolactin secretion. Brain Research August 8, 1983
- Subsensitivity of serotonin and substance P receptors involved in nociception after repeated administration of a serotonin receptor agonist. Journal of Neural Transmission 1989
- Indolealkylamines and prolactin secretion. A structure-activity study in the central nervous system of the rat. Neuropharmacology December 1, 1985
and 1 more in the library
Cites 4
- Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by l‐tryptophan or 5‐methoxy‐N,N‐dimethyltryptamine in rats treated with a monoamine oxidase inhibitor British Journal of Pharmacology December 1, 1971
- The psychedelic model of schizophrenia: the case of N,N- dimethyltryptamine American Journal of Psychiatry February 1, 1976
- Tolerance and limited cross-tolerance to the effects of N, N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) on food-rewarded bar pressing in the rat. Journal of Pharmacology and Experimental Therapeutics June 1, 1976
- Stimulation of rat prolactin secretion by indolealkylamine hallucinogens. Psychopharmacology April 11, 1978