Pharmacology, Biochemistry, and Behavior
April 1978
N S Shah, M P Hedden
Behavioral aspects and metabolic fate of N,N-dimethyltryptamine (DMT) were studied in mice pretreated with beta-diethylaminoethyl-diphenylpropylacetate (SKF 525-A), iproniazid or chlorpromazine (CPZ). DMT at doses of 2.5, 10.0, and 25.0 mg/kg produced several behavioral changes in a dose-related manner: inhibition of spontaneous locomotor movement, enhanced fright responses to sound stimuli,...
Journal of Medicinal Chemistry
1978
Richard A Glennon, Stephen M. Liebowitz, Elizabeth C. Mack
35 citations
Hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues are known to affect serotonergic systems both in vivo and in vitro. Using a rat stomach fundus model, the 5-HT receptor binding affinities of several of these analogues were determined and compared. The most behaviorally potent analogues examined, DOB, DOM, and 5-methoxy-N,N-dimethyltryptamine, were found to possess rather...
Pharmacology, Biochemistry, and Behavior
February 1977
S E File
The processes involved in habituation and the various ways drugs might affect habituation are discussed. Exploration was measured in a holehoard and N,N-Dimethyltryptamine (DMT, 4 mg/kg) profoundly reduced the level of exploration, precluding any conclusions about the rate of habituation with this dose. However, both 2 and 4 mg/kg doses prevented the 24-hr retention of habituation of...
Pharmakopsychiatrie, Neuro-Psychopharmakologie
January 1977
P Bickel, A Dittrich, J Schöpf
In a controlled study on 38 volunteers the effects of 250 micrograms/kg N,N-dimethyltryptamine (DMT) i.m. on objective and performance tests measuring psychoticism according to Eysenck were assessed. The hypothesis was tested that subjects treated with DMT (N = 26) differ from those receiving placebo (N = 12) in the same way as endogenous psychotics differ from normals. Confirmation was...
Archiv fur Psychiatrie und Nervenkrankheiten
December 31, 1976
A Dittrich, P Bickel, J Schöpf et al.
8 citations
The study compares altered states of consciousness induced by the hallucinogens (--)delta9-trans-Tetrahydrocannabinol (delta9-THC) and N,N-Dimethyltryptamine (DMT) using two placebo control groups. A total of 24 subjects received 250 mug delta9-THC p.o./kg body weight and 26 subjects were treated with 250 mug DMT i.m./kg. Placebo was given to 24 subjects. The effects were assessed by a...
Pharmakopsychiatrie, Neuro-Psychopharmakologie
September 1, 1976
P Bickel, A Dittrich, J Schoepf
12 citations
In a controlled study on 38 volunteers the effects of 250 mcg/kg N,N-Dimethyltryptamine (DMT) i.m. were assessed. 26 subjects received DMT and 12 placebo. The altered states of consciousness and the somatic changes were measured by several questionnaires administered after the experiment. In spite of the low dose as compared to previous studies significant differences to placebo were found in...
Journal of Pharmacology and Experimental Therapeutics
June 1, 1976
Beverly Kovacic, E. F. Domino
33 citations
Lysergic acid diethylamide=25 (LSD) and N,N-dimethyltryptamine (DMT) abolish food-rewarded, fixed-ratio bar pressing by rats in a dose-related fashion. Adult male Holtzman rats trained to press a bar (respond) for milk reward on a 4-response fixed-ratio schedule were given i.p. injections of 3.2 or 10 mg/kg of DMT every 2 hours for 21 days. Every 24 hours the animals were placed in operant...
American Journal of Psychiatry
February 1, 1976
123 citations
The authors review the research on N,N-dimethyltryptamine (DMT) as a possible "schizotoxin." DMT produces psychedelic effects when administered to normal subjects, the means are present to synthesize it in man, it has occasionally been found in man, and tolerance to its behavioral effects is incomplete. However, DMT concentrations have not been proven to differ significantly in schizophrenics...
Chemischer Informationsdienst
January 20, 1976
T. Hino, H. Miura, T. Nakamura et al.
AbstractAus den Indolderivaten (Ia)‐(Ic) erhält man bei der oxidativen Cyclisierung mit N‐Brom‐ oder N‐Chlorsuccinimid die entsprechenden Cyclisierungsprodukte (IIa)‐(IIc).
Psychopharmacology
1976
B. Angrist, S. Gershon, G. Sathananthan et al.
44 citations
A gas chromatographic-mass spectrometric determination of blood N,N-dimethyltryptamine in normal controls and schizophrenic patients was carried out with a sensitivity limit of 0.05 ng/ml whole blood. Although the results appear to suggest that the mean DMT level was higher in the total patient group, those patients with acute psychosis, female patients and patients with suspiciousness scores...