Brain Behavior and Immunity Integrative
September 14, 2024
Bianca Castro Dos Santos, Ana Kéren Gomes Reis, Ricardo Aparecido Baptista Nucci et al.
1 citation
Neuropathic pain (NP), a debilitating and chronic condition often accompanied by comorbid depression, presents significant therapeutic challenges. While conventional pharmacological treatments, though valuable, usually fall short in addressing their multifaceted nature, the pursuit of innovative solutions has led to the exploration of ayahuasca , a psychedelic brew originating from Amazonian...
Philosophical Perspectives on Psychedelic Psychiatry
September 13, 2024
Jaipreet Mattu, Jacqueline Sullivan
Abstract In the last decade alone, preliminary evidence has suggested that classic psychedelics (CPs) can rapidly and durably ameliorate symptoms and cognitive deficits associated with depression. However, the mechanisms by which CPs work in the brain are not well understood. Rodent translational research, in which experimental findings from rodents are used to understand the human brain, is...
Philosophical Perspectives on Psychedelic Psychiatry
September 13, 2024
Virginia Ballesteros
1 citation
Abstract This chapter provides a philosophical account of the potential of the psychedelic experience to treat depression. The main thesis is that such a potential lies in the possibility of psychedelics allowing us to experience a world diametrically opposed to that of depression: the psychedelic experience can be world-shifting. Building on Ludwig Wittgenstein’s insights and notions of...
African Journal of Biomedical Research
September 11, 2024
Pallavi Sharma
The adolescence, a transition phase from childhood to adulthood, is exposed to critical development changes in multiple domains including physical, cognitive, emotional, social, moral, sexual and academic.There is also an increased probability of troubles or illness such as negative behaviour, drug abuse, depression, stress and anxiety which if not addressed could make the transition to...
Stem cell research & therapy
September 11, 2024
Xiaoxu Dong, He Lin, Yuting Li et al.
1 citation
Accumulating evidence has shown that some hallucinogens, such as LSD, have fast and persistent effects on anxiety and depression. According to a proposed mechanism, LSD activates the TrkB and HTR2A signaling pathways, which enhance the density of neuronal dendritic spines and synaptic function, and thus promote brain function. Moreover, TrkB signaling is also known to be crucial for neural stem...
Cellular and Molecular Life Sciences
September 10, 2024
Klemens Egger, Helena Aicher, Paul Cumming et al.
30 citations
The potent hallucinogen N,N-dimethyltryptamine (DMT) has garnered significant interest in recent years due to its profound effects on consciousness and its therapeutic psychopotential. DMT is an integral (but not exclusive) psychoactive alkaloid in the Amazonian plant-based brew ayahuasca, in which admixture of several β-carboline monoamine oxidase A (MAO-A) inhibitors potentiate the activity...
Journal of Psychoactive Drugs
September 10, 2024
Nilubon Thaoboonruang, Manupat Lohitnavy, Ornrat Lohitnavy
11 citations
Psilocybin, a major indole alkaloid found in magic mushrooms (Psilocybe cubensis), has recently drawn attention as a breakthrough therapy to treat major depressive disorder. This review aimed to summarize and identify knowledge gaps concerning their pharmacokinetic characteristics of psilocybin and its active metabolite, psilocin. Original studies related to pharmacokinetics of psilocybin...
Revista Interamericana de Psicología/Interamerican Journal of Psychology
September 9, 2024
Lee Fergusson, Javier Ortiz Cabrejos, Anna Bonshek
In a post-pandemic Perú, problems associated with the mental health of children have been highlighted and effective methods of intervention have been discussed. This study sought to examine: 1) current levels of depression, anxiety, and stress in Perúvian school children; 2) how these levels compare to other children in Latin America and elsewhere; 3) whether these levels are different when...
medRxiv
September 6, 2024
Hendrik-Jan De Vuyst, Angeliki-Ιlektra Karaiskou, Javier R. Soriano et al.
preprint
Abstract Objectives Neurofeedback training involves real-time monitoring and self-regulation of neural activity. Neurofeedback training paradigms have been widely employed in the context of meditation. Interestingly, prior research revealed focused attention meditation to be associated with desynchronized, non-harmonic, cross-frequency relationships between alpha and theta rhythms, suggesting...
Social Medicine
September 6, 2024
Timi Thomas, Neetha Kamath, Gincy Joseph
Introduction. The time of examination and evaluation is a stressful period where anxiety is at its highest levels. To some extent, a low level of stress can help motivate the students; however, more stress can be discouraging. It will make students exhausted, overwhelmed, and confused. High self-esteem promotes physical health and enhances coping with threat; on the other hand, low self-esteem...