Toxicological sciences : an official journal of the Society of Toxicology
November 1, 2025
Naphat Wittayakarn, Yu-Mei Tan, Pattanachai Choomalaiwong et al.
Ayahuasca is a traditional Amazonian brew composed of Psychotria viridis, containing N,N-dimethyltryptamine (DMT), and Banisteriopsis caapi, which includes harmala alkaloids such as harmine. Ayahuasca can produce potent psychoactive effects primarily due to DMT, whose metabolism is inhibited by harmine via monoamine oxidase-A enzymes. This inhibition increases DMT's systemic bioavailability,...
Scientific Reports
April 21, 2025
Nilubon Thaoboonruang, Ornrat Lohitnavy, Kimheang Ya et al.
4 citations
Psilocybin is an active alkaloid found in magic mushrooms (Psilocybe cubensis). It is classified as a Class I Psychoactive Substance due to its psychoactive properties. Recent research has suggested that psilocybin holds potential for treating major depressive disorder. The objective of this study was to develop a physiologically based pharmacokinetic (PBPK) model for psilocybin and its active...
Journal of Psychoactive Drugs
September 10, 2024
Nilubon Thaoboonruang, Manupat Lohitnavy, Ornrat Lohitnavy
11 citations
Psilocybin, a major indole alkaloid found in magic mushrooms (Psilocybe cubensis), has recently drawn attention as a breakthrough therapy to treat major depressive disorder. This review aimed to summarize and identify knowledge gaps concerning their pharmacokinetic characteristics of psilocybin and its active metabolite, psilocin. Original studies related to pharmacokinetics of psilocybin...
F1000Research
March 15, 2021
Prinya Musikaphongsakul, Kimheang Ya, Pakpoom Subsoontorn et al.
6 citations
Background: Psilocybin (PB) is a psychoactive compound commonly found in magic mushroom (Psilocybe cubensis). PB is quickly converted by the body to psilocin (PI), which has a psychedelic effect through the activation of the 5-HT2A receptor in the brain. The objective of this study is to develop a physiologically based pharmacokinetic (PBPK) model of PB and PI in rats and humans for predicting...