OPAL (Open@LaTrobe) (La Trobe University) - The Consciousness Library

Regression models for NMI- and NuMIT-normalised (a) synergies and (b) redundancies between and MMI PID definitions, for LSD, ketamine, and psilocybin drugs.

OPAL (Open@LaTrobe) (La Trobe University) November 5, 2025 Alberto Liardi (22305679), Fernando E. Rosas (9595503), Robin L. Carhart-Harris (5923571) et al.

Δ indicates the differences between drug and placebo in PID atoms obtained with either PID (MMI or CCS).

DOI: 10.1371/journal.pcbi.1013629.g005 Psilocybin Pid controller Control theory sociology Artificial intelligence +2

PID-atom distributions for all subjects under different drugs and placebo effects using MMI definition.

OPAL (Open@LaTrobe) (La Trobe University) November 5, 2025 Alberto Liardi (22305679), Fernando E. Rosas (9595503), Robin L. Carhart-Harris (5923571) et al.

From left to right, results refer to LSD, ketamine, and psilocybin drugs. Panel rows represent (a) the raw values of PID atoms, (b) the NMI-normalised PID atoms, and (c) the NuMIT-normalised PID atoms. The dashed black lines are drawn at zero. (P-values calculated with a one-sample t-test against the zero-mean null hypothesis. *: ppp<0.001).

DOI: 10.1371/journal.pcbi.1013629.g004 Pid controller Placebo Pharmacology

S1 Appendix - Psilocybin-assisted group psychotherapy and mindfulness-based stress reduction for frontline healthcare provider COVID-19-related depression and burnout: A randomized controlled trial

OPAL (Open@LaTrobe) (La Trobe University) September 19, 2025

Supplement 1. Additional tables presenting primary and secondary outcomes, sensitivity analyses, and exploratory findings. Table A1. ITT analyses for QIDS-SR-16 and MBI-HSS-MP. Table A2. Adjusted ITT analyses for QIDS-SR-16 and MBI-HSS-MP. Table B1. Intent-To-Treat (ITT) Analysis for Demoralization Scale (DSII) and PTSD Checklist for DSM-5 (PCL-5). Table B2. Adjusted Intent-To-Treat (ITT)...

DOI: 10.1371/journal.pmed.1004519.s001

Study flow chart.

OPAL (Open@LaTrobe) (La Trobe University) September 19, 2025

Background Depression and burnout, which are common among healthcare workers, were exacerbated by the COVID-19 pandemic. Mindfulness-Based Stress Reduction (MBSR) and psilocybin have been reported to reduce depressive symptoms, but the efficacy of the combination requires comparison to an active treatment control. We sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR...

DOI: 10.1371/journal.pmed.1004519.g001

Study CONSORT diagram.

OPAL (Open@LaTrobe) (La Trobe University) September 19, 2025

Background Depression and burnout, which are common among healthcare workers, were exacerbated by the COVID-19 pandemic. Mindfulness-Based Stress Reduction (MBSR) and psilocybin have been reported to reduce depressive symptoms, but the efficacy of the combination requires comparison to an active treatment control. We sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR...

DOI: 10.1371/journal.pmed.1004519.g002

Study-related adverse events.

OPAL (Open@LaTrobe) (La Trobe University) September 19, 2025

Background Depression and burnout, which are common among healthcare workers, were exacerbated by the COVID-19 pandemic. Mindfulness-Based Stress Reduction (MBSR) and psilocybin have been reported to reduce depressive symptoms, but the efficacy of the combination requires comparison to an active treatment control. We sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR...

DOI: 10.1371/journal.pmed.1004519.t002

Additional file 1 of “I’ve learned that I’m open-minded to this possibility”: A qualitative study to evaluate the acceptability of a psilocybin-aided smoking cessation treatment for people with HIV who smoke

OPAL (Open@LaTrobe) (La Trobe University) July 22, 2025 Patricia A. Cioe, Garrett S. Stang, Danish Azam et al.

Supplementary Material 1

DOI: 10.6084/m9.figshare.29615217.v1 Qualitative research Smoking cessation Smoke Qualitative analysis +2

Participant demographics (weighted %).

OPAL (Open@LaTrobe) (La Trobe University) May 7, 2025

Background: Opioid use disorder (OUD) is a debilitating health condition that is associated with significant morbidity and mortality in the U.S. While preliminary studies have demonstrated that psilocybin is associated with lowered odds of OUD, current research in this domain suffers from a lack of investigation into the impact of race/ethnicity on this association. Objective: To assess the...

DOI: 10.1371/journal.pone.0321461.t001

Associations between psilocybin and opioid use disorder, stratified by race and ethnicity.

OPAL (Open@LaTrobe) (La Trobe University) May 7, 2025

Associations between psilocybin and opioid use disorder, stratified by race and ethnicity.

DOI: 10.1371/journal.pone.0321461.t004

Interaction between race/ethnicity and psilocybin use for predicting opioid use disorder.

OPAL (Open@LaTrobe) (La Trobe University) May 7, 2025 Grant Jones (338384)

Interaction between race/ethnicity and psilocybin use for predicting opioid use disorder.

DOI: 10.1371/journal.pone.0321461.t003 Psilocybin Opioid Hallucinogen Pharmacology +1

Participant demographics (unweighted counts).

OPAL (Open@LaTrobe) (La Trobe University) May 7, 2025

Background: Opioid use disorder (OUD) is a debilitating health condition that is associated with significant morbidity and mortality in the U.S. While preliminary studies have demonstrated that psilocybin is associated with lowered odds of OUD, current research in this domain suffers from a lack of investigation into the impact of race/ethnicity on this association. Objective: To assess the...

DOI: 10.1371/journal.pone.0321461.t002

Effects of psilocybin on the human brain functional network

OPAL (Open@LaTrobe) (La Trobe University) 2013 Weissbart Hugo

MSc Final year thesis (Imperial College of London, Department of physics)

DOI: 10.6084/m9.figshare.798836.v1 Psilocybin Human brain Hallucinogen

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