PsyArXiv
October 27, 2025
JD Rolfes
preprint
Background: Psychedelic-assisted therapies show promise for MDD, PTSD, and addiction, yet mechanisms are often framed as 5-HT2A-centric, despite evidence of GABAergic pathology in these conditions.Hypothesis (Author Perspective): As a chemist examining psychedelic pharmacology, I propose that inhibitory-circuit modulation acts as a necessary systems-level gate converting transient 5-HT2A...
Journal of Psychopharmacology
October 27, 2025
David Nutt, Celia J. A. Morgan, David Erritzøe et al.
2 citations
It is 60 years since ketamine was first tested in humans as an alternative but safer anaesthetic to PCP (phencyclidine) (Corssen and Domino 1966). It became widely used as the “buddy drug” for combatants in the Vietnam War: because of its great safety margin, it could be injected into wounded personnel by their buddies to relieve pain before the arrival of the medical team. Because of...
International Journal of Latest Technology in Engineering Management & Applied Science
October 25, 2025
Jajbir Singh
Abstract: Yoga has transcended its traditional Indian roots to become a global therapeutic practice with measurable neurobiological effects. Emerging neuroscientific research demonstrates that yogic practices that comprising asana (postures), pranayama (breath regulation), and dhyana (meditation) induce structural and functional brain changes associated with improved mental health, emotional...
Research Square
October 24, 2025
Emilio Durán, Manuel Vázquez-Frutos, Elisa Alcocer et al.
preprint
Abstract Objectives: Depression is linked to abnormalities in resting-state networks (RSNs) such as the Default Mode Network (DMN), Salience Network (SN), and Frontoparietal Network (FPN). Mindfulness-based interventions (MBIs) are effective for treating depression, but their impact on functional connectivity (FC) within and between RSNs remains unclear. This systematic review synthesizes...
PsyArXiv
October 24, 2025
Barry Tse, Melody Jia-Qi Xu
preprint
MBCT combines ancient mindfulness practices with the structured approaches of modern CBT, creating an effective intervention for preventing depressive relapse and addressing a wide range of psychological conditions. The authors explore MBCT's development from its Eastern spiritual origins to its validation in Western clinical contexts. They discuss the dual theoretical frameworks underpinning...
BMJ Open
October 23, 2025
Jiheun Hong, Christopher R Shelton, Hayoung Oh
Stress is a major health issue in contemporary society, and mindfulness-based approaches reduce stress and anxiety but face practical barriers to consistent practice; this protocol evaluates a Virtual Reality (VR)-based observation meditation programme with an artificial intelligence (AI) coach ('Otti') that delivers real-time empathic, tailored prompts to support present-focused attention and...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
October 23, 2025
Danielle Bukovsky, Aron Amaev, Jianmeng Song et al.
Psilocybin, a psychedelic prodrug, has gained renewed interest for its potential to treat various psychiatric disorders, including depression, anxiety, and substance use disorders. While promising, concerns remain regarding its safety profile and the management of potential adverse events (AEs). This systematic review aimed to evaluate the incidence, nature, and severity of adverse events and...
medRxiv
October 22, 2025
Matthew A Aldridge, Nanda Cara, Alan Simpson et al.
preprint
Abstract Second-generation mindfulness-based interventions (SG-MBIs) extend typical mindfulness-based interventions (MBIs) by grounding them in Buddhist epistemological and pedagogical frameworks and integrating additional Buddhist-derived practices. Systematic reviews show that MBIs can reduce burnout, distress, anxiety, depression and stress among university students—an issue of increasing...
Journal of Affective Disorders
October 21, 2025
Objective: The current study aimed to explore the effectiveness and mechanisms of mindfulness on alleviating both immediate and delayed negative interpretation biases (NIB). Method: A total of 105 college students (female: 84.62 %, age: 17-23) with high levels of depression were randomly assigned to a mindfulness-writing group, a mindfulness-only group and a waiting list group, and completed...
JAMA
October 21, 2025
Reid Robison, Robert Barrow, Craig Conant et al.
22 citations
Effective and well-tolerated pharmacotherapies for generalized anxiety disorder (GAD), which is one of the most common psychiatric disorders, are needed. To determine the dose-response relationship of MM120 (lysergide D-tartrate) in adults with moderate to severe GAD. This phase 2b, multicenter, randomized, double-blind, placebo-controlled study enrolled 198 adults aged 18 to 74 years with a...