Biomedicine & Pharmacotherapy
October 30, 2025
Rubén García‐cabrerizo, Itziar Beruete-Fresnillo, Pedro Bergas-Cladera et al.
3 citations
Adolescent depression is a significant public health concern, yet treatment options remain limited, particularly due to age- and sex-related differences in antidepressant efficacy. This study explored for the first time the potential antidepressant-like response of psilocybin in adolescence by examining acute, repeated and persistent effects in Sprague-Dawley rats of both sexes, as measured...
bioRxiv (Cold Spring Harbor Laboratory)
December 22, 2024
Rubén García‐cabrerizo, Itziar Beruete-Fresnillo, M. Julia García‐fuster
2 citations
preprint
Abstract Adolescent depression is a significant public health concern, yet treatment options remain limited, particularly due to age- and sex-related differences in antidepressant efficacy. This study explored the rapid and long-lasting antidepressant-like potential of psilocybin in adolescent Sprague-Dawley rats, examining acute and repeated oral dosing effects while incorporating sex as a...
Neurotoxicology
September 2016
Rubén García‐cabrerizo, M Julia García-Fuster
The aim of this study was to compare the effects of amphetamine-like psychostimulant drugs (i.e., MDMA, methamphetamine, D-amphetamine) on rat hippocampal cell genesis at different developmental ages (i.e., early adolescence vs. young adulthood) to determine if there were periods of vulnerability to drug-induced brain changes. Although adolescence is a period of great vulnerability to the...
Neurotoxicology
July 2015
Rubén García‐cabrerizo, M Julia García-Fuster
While hippocampus is a brain region particularly susceptible to the effects of MDMA, the cellular and molecular changes induced by MDMA are still to be fully elucidated, being the dosage regimen, the species and the developmental stage under study great variables. This study compared the effects of one and four days of MDMA administration following a binge paradigm (3×5 mg/kg, i.p., every 2 h)...