Psychedelics are increasingly described as a new therapeutic approach in a variety of mental disorders including depression. Oral psychedelics such as psilocybin have an acute effect evolving over 6-8 h and are generally given in combination with psychological support. There is debate on the exact role of this support and how and by whom it should be delivered. This has significant implications...
Ketamine, a dissociative anesthetic, has been extensively used in clinical anesthesia and sedation. However, its use in general anesthesia is gradually declining because of numerous adverse effects. In 2019, esketamine was introduced to the Chinese market. This narrative review aimed to summarize the current status of clinical applications and research progress of esketamine and to explore its...
Abstract Background Determining health information quality on online drug platforms is crucial for revealing and shaping substance use practices. The study aims to assess the scope and quality of health-related information on the largest Polish drug forum, Hyperreal. Ultimately, the goal was to explore how the case of Hyperreal illustrates user-driven knowledge construction around drug use and...
Quality in SportMarch 28, 2026Klaudia Pazio, Michał Piskor, Dominika Strzalińska et al.
Cancer is a major burden in both the somatic and psychological dimensions. Oncology patients often experience high levels of stress, anxiety, depression, and reduced quality of life resulting from both the diagnosis itself and the course of treatment. In recent years, growing attention has been paid to psychosocial interventions that help patients cope with these difficulties. One such approach...
Mescaline, the primary bioactive alkaloid found in Peyote and San Pedro cactus, has been used in traditional medicine for centuries and is now attracting renewed interest for clinical applications. The purpose of this systematic review was to search the literature for studies reporting the use of mescaline to address the gap in our understanding of mescaline use and its impact. References were...
Background/Objectives: Chemsex is defined as the intentional use of psychoactive substances to enhance or prolong sexual activity, predominantly observed among men who have sex with men. It has emerged as a notable behavioral and public health concern due to its association with high-risk sexual practices, psychiatric morbidity, and somatic complications. Despite increasing recognition, global...
Introduction: University students are vulnerable to psychological distress due to the academic and social demands of this life stage. Mindfulness and self-compassion are effective and adaptable strategies in an academic environment that promote emotional regulation and psychological well-being. This study aims to conduct a systematic review and meta-analysis to evaluate the combined impact of...
Abstract Objectives Deconstructive meditative practices (DMPs) aim to transform the perception of the self by fostering an understanding of its constructed and impermanent nature through self-inquiry. This systematic review evaluated the effectiveness of DMPs in improving mental health and psychological well-being among adults. Method Following PRISMA guidelines, a comprehensive search was...
N,N-dimethyltryptamine (DMT) is a serotonergic psychedelic that produces short-lived peak effects when administered intravenously as a bolus dose. Initial trials suggested therapeutic effects of DMT in depressive disorders. However, systematic data on dose-dependent pharmacokinetics and acute effects of intravenous bolus DMT administration are currently lacking. We used a double-blind,...
ElifeMarch 27, 2026Målin Schmidt, Anne Hoffrichter, Mahnaz Davoudi et al.3 citations
Psilocybin is studied as innovative medication in anxiety, substance abuse and treatment-resistant depression. Animal studies show that psychedelics promote neuronal plasticity by strengthening synaptic responses and protein synthesis. However, the exact molecular and cellular changes induced by psilocybin in the human brain are not known. Here, we treated human cortical neurons derived from...