Brain SciencesMarch 26, 2026Piotr Skalski, Katarzyna Pękacka-falkowska, Agnieszka Pluto-Prądzyńska et al.
Background/Objectives: Psilocybin has re-emerged as a promising intervention for neuropsychiatric disorders including major depressive disorder, treatment-resistant depression, anxiety associated with life-threatening illness, obsessive compulsive disorder, and substance use disorders. However, conventional randomized controlled trials (RCTs)-the current gold standard in evidence-based...
Pain MedicineMarch 25, 2026Lorena S Nunes, Angela C. Incollingo Rodriguez, Benjamin C. Nephew et al.
Dear Editor, Chronic low back pain (cLBP) is increasingly prevalent across populations and ages.1 Low back pain is currently the leading cause of disability worldwide.2 Beyond widespread effects on individual functioning and well-being, the financial,3 psychological,4 and social5 implications of cLBP are vast. Mindfulness-based stress reduction (MBSR) is effective in decreasing various pain...
BACKGROUND: Neuroinflammation is a hallmark of numerous neuropsychiatric and neurodegenerative disorders. Psychedelics have garnered recent attention for their anti-inflammatory and neuroprotective effects. However, it remains unknown whether they can prophylactically prime immune pathways to prevent subsequent neuroinflammatory responses, and whether such effects depend on serotonin 5-HT2A...
INTRODUCTION: After decades of regulatory marginalization, psychedelic compounds have reemerged as promising therapeutic tools in psychiatry, driven by unmet clinical needs in treatment-resistant mental disorders and by growing evidence of rapid and sustained effects on mood, cognition, and behavior. AREAS COVERED: This narrative review critically examined the current clinical and regulatory...
Nach einer Pause gibt es heute wieder Evidenz-Quickies, und zwar gleich mehrere, dafür aber kürzer und weniger ausführlich als zuletzt. Und dieses Format ist jetzt zweigeteilt: (a) Für alle, denen die Nachricht genügt, gibt es oben die Quickies in Kürze. (b) Alle, die weiterlesen wollen, finden die detaillierten Fassungen unten. Viel Freude und hoffentlich interessante Lektüre! 🍄 Psilocybin bei...
Psilocybin, N,N-dimethyltryptamine (DMT), lysergic acid diethylamide (LSD), and 3,4-methylenedioxymethamphetamine (MDMA) are psychedelic compounds with therapeutic potential for depression, anxiety, and post-traumatic stress. However, their relevance to endurance athletes, who face particular psychological and physical stressors, remains underexplored. This study combines a conceptual overview...
Salud MentalMarch 19, 2026Nilson Vieira Pinto, R. Sousa, Moreira Sarmento Vivianne Dos Santos et al.
Introduction. Although anxiety and depression disorders in adolescence are considered a worrying public health problem, there is a dearth of research on the issue, particularly of intervention strategies in the school environment designed to improve students’ mental health. Objective. To evaluate the quality of life and anxiety, stress, and depression levels in high school adolescents regularly...
Stress triggers mind-body symptoms by activating the autonomic nervous system through the brain. Neuroimaging studies have identified the anterior cingulate cortex (ACC) and the insular cortex as being central to this interaction. Abnormalities in these regions have been linked to stress-related disorders such as depression, irritable bowel syndrome, and chronic pain. Recent research shows that...
Psilocybin-assisted therapies are innovative therapeutic approaches, particularly in the treatment of depression. However, there are sparse studies providing functional magnetic resonance imaging (fMRI) evidence elucidating the underlying biological mechanisms that support clinical outcomes. This review aims to comprehensively gather all the evidence reported in psilocybin studies using fMRI...
Smartphone addiction among college students is strongly associated with elevated psychological distress, including depression, anxiety, and chronic stress. While yogic interventions show promise for mental health improvement, limited evidence exists comparing yogic practices alone versus combined with yoga nidra for psychological outcomes in this population. We aimed to evaluate whether yogic...