Psilocybin, a serotonergic psychedelic, has gained attention as a potential treatment for various psychiatric conditions. In this review, the authors summarize current clinical evidence related to psilocybin’s efficacy, safety, and mechanisms of action across psychiatric disorders. Findings from early-phase and small-scale clinical trials suggest rapid but variable reductions in depressive...
Major depressive disorder (MDD) imposes a substantial burden worldwide, with treatment-resistant depression (TRD) and major depressive disorder with acute suicidal ideation or behavior (MDSI) representing two of the most severe clinical challenges. Conventional antidepressants often require several weeks to exert benefit, leaving patients symptomatic and at risk during this delay. Esketamine...
Poor insight is a core feature of schizophrenia and empirical studies have demonstrated associations with important symptom domains, cognitive functions, and clinical outcomes. While recent explanatory accounts mostly focus on neuro-, social-, or meta-cognitive deficits, a complementary model from phenomenological psychopathology suggests that impaired insight in schizophrenia is tied to...
This systematic review and meta-analysis investigated the effect of Mindfulness Based Stress Reduction (MBSR) on pain severity, quality of life, pain catastrophising, and depression for people living with Fibromyalgia (FM) at short and long term follow up. MEDLINE, EMBASE, CENTRAL, ClinicalTrials.gov, WHO Trial Registry, CINAHL and PsychInfo were searched from inception to December 2025 for...
Brain and BehaviorApril 1, 2026Sharon Murphy, Elizabeth Stewart, Jacqueline Ruth. Winship et al.1 citation
PURPOSE: Psychedelic-assisted therapy (PAT) is becoming a clinically available treatment for patients with treatment-resistant conditions such as depression and post-traumatic stress disorder (PTSD) in several countries. As PAT transitions from research settings into routine clinical practice, there is a growing need for coherent clinical frameworks and evidence-based guidelines to support its...
(R,S)-Ketamine, a dissociative anesthetic, has shown rapid and sustained antidepressant effects at lower doses than those required for anesthetic effects in patients with treatment-resistant depression. However, its use is limited because it causes side effects, including psychotomimetic symptoms and dependence. The enantiomer (R)-ketamine was reported to promote antidepressant-like effects in...
CureusApril 1, 2026Samantha Siu, Peter Hsin, Sarah Simon et al.
Postpartum depression (PPD) is a common condition associated with adverse maternal and infant outcomes. Higher rates have been observed following cesarean delivery, prompting interest in perioperative preventive strategies. Ketamine has demonstrated rapid antidepressant effects and may provide psychiatric benefits beyond analgesia. We conducted a systematic review and meta-analysis of...
Psilocybin showed a rapid antidepressant response in several clinical trials, which offers new hope for treating depression. Astrocytes were associated with the etiology of depression and might contribute to the onset of psilocybin. In this study, we investigated the fast antidepressant effect of psilocybin and tested variations of GFAP (astrocytic markers) and C3 protein (markers of A1...
Penelitian ini bertujuan untuk menganalisis perkembangan, struktur pengetahuan, dan tren penelitian dalam bidang mindfulness-based counseling melalui pendekatan bibliometrik. Data diperoleh dari basis data Scopus dengan rentang waktu publikasi 2005–2025, kemudian dianalisis menggunakan perangkat lunak VOSviewer untuk mengidentifikasi pola kolaborasi, jaringan kata kunci, serta dinamika tematik...
Yoga practices date back to ancient times. It is a mechanism that connects our mind, body, and soul consisting of different movements and poses performed in coordination with controlling breath, meditation, relaxation, and lifestyle. In recent years, yoga therapy has gained a huge amount of attention and shown promising results as a complementary treatment for psychological disorders and...