Open MindJuly 9, 2026Emma Wiethoff, Barbara Breitenstein, Nina Hartter et al.
preprint
This preregistration specifies hypotheses and an analysis plan for a randomized controlled trial comparing Conscious Connected Breathing (CCB) with Progressive Muscle Relaxation (PMR) in adults with a history of childhood adversity. The primary outcome is change in self-compassion from pre- to post-intervention. Secondary analyses examine whether altered states of consciousness during CCB...
In recent years, psychedelics have shown promising results as therapeutic interventions for individuals with depression, terminal illnesses, substance use disorder, neurodegenerative diseases, trauma and obsessive-compulsive disorder. Moreover, research involving psychedelics have contributed to the understanding of the neurobiological mechanisms behind the "psychedelic state of consciousness"...
Background: Postoperative depressive symptoms may impair recovery and quality of life in patients undergoing breast cancer surgery. Esketamine has shown potential antidepressant and analgesic effects in the perioperative setting. This meta-analysis evaluated the efficacy and safety of perioperative esketamine for postoperative depressive symptoms in patients undergoing breast cancer surgery....
BACKGROUND Patients undergoing peritoneal dialysis (PD) frequently experience anxiety and sleep disturbances.However, the comparative efficacy of psychological interventions on these symptoms remains unclear.AIM To compare the efficacy of mindfulness-based cognitive therapy (MBCT) and routine psychological support (PS) on anxiety symptoms and sleep quality in patients undergoing PD.METHODS This...
Background Zoletil 50, mixed with tiletamine and zolazepam, a veterinary anesthetic, has increasingly been used as a substitute drug by substance abusers in recent years. Recently, it has been found in China that tiletamine has been added to electronic cigarettes as a stimulant, highlighting the need for further evaluation of its safety. Case presentation A 22-year-old, previously healthy,...
The serotonin 1B receptor can be studied in vivo with PET using [^11C]AZ10419369, and has been linked to both the pathophysiology and treatment of major depressive disorder (MDD). Ketamine and electroconvulsive therapy (ECT) both exert rapid and potent antidepressive effects, and although these treatments may not act directly on the serotonin system, they both cause dose-dependent increases in...
Background The COVID-19 pandemic has resulted in a significant increase in mental health issues, including depression, anxiety, post-traumatic stress disorder and sleep disturbances, particularly among recently hospitalised patients. Non-pharmacological interventions such as Yoga Nidra and Music Therapy offer cost-effective and accessible alternatives for improving psychological well-being and...
Biology of Sex DifferencesJuly 7, 2026Gemma González-Hernández, S. Torres-Sánchez, D. Sanchez-Morillo et al.
Chronic pain-depression comorbidity is characterized by sensory hypersensitivity and emotional dysregulation, and has been linked to alterations in prefrontal network connectivity. It represents a major therapeutic challenge due to its pronounced sex differences in symptom manifestation and increased treatment resistance. Nitrous oxide (N₂O), an inhalational anesthetic traditionally used for...
This multiple methods study examines the feasibility, acceptability, and preliminary outcomes associated with participation in the Mindfulness and Self‐Compassion for Children and Caregivers course (MSC‐CC). School‐age youth are experiencing unprecedented levels of anxiety and depression. Self‐compassion skills are accessible, evidence‐based, transdiagnostic tools that can help children...
Open Minds International JournalJuly 6, 2026Juliana Leite Haubman, João Octávio Celante da Silva, Bruno Horta Leonardo Machado de Moura et al.
Intravenous esketamine represents a significant therapeutic innovation in the field of psychiatry, particularly in the management of treatment-resistant depression and severe psychiatric conditions associated with suicidal ideation.Derived from the S-enantiomer of ketamine, esketamine acts primarily as an N-methyl-D-aspartate (NMDA) receptor antagonist, promoting rapid glutamatergic modulation...