Introduction: Treatment-resistant depression (TRD) represents a significant clinical challenge, particularly when associated with suicidal ideation. Intranasal esketamine has emerged as an effective therapeutic option in refractory cases, while monoamine oxidase inhibitors (MAOIs) remain relevant in the management of severe and resistant conditions. Objective: To describe the clinical course of...
Human Immunodeficiency Virus (HIV) infection remains a complex psychological and social challenge, particularly for women in the postpartum period. This case study aimed to illustrate the effectiveness of a mindfulness-based cognitive therapy (MBCT) within the biopsychosocial framework in reducing psychological distress in an HIV-positive housewife who had been diagnosed with a depressive...
Psilocybin-assisted therapy has emerged as a promising intervention for treatment-resistant depression (TRD), yet standardized and transparent therapeutic frameworks remain limited. This therapist manual was developed for the EPIsoDE trial, a phase IIb randomized clinical study investigating the efficacy and safety of psilocybin with adjunct psychotherapy in patients with TRD (NCT04670081). The...
Background: Depression is a significant mental health condition affecting numerous individuals worldwide, leading to disability within society and posing a heightened risk of suicide, thereby diminishing overall quality of life. Depression, often a contributing factor in suicides, is associated with various prevalent medical conditions such as obesity, diabetes, stroke, Parkinson's disease, and...
PsychopathologyMarch 27, 2026Xiaoran Ding, Yaping Wu, Juan Yang et al.1 citation
Ketamine has emerged as a promising rapid-acting antidepressant with distinct advantages for the treatment of treatment-resistant depression (TRD). Its therapeutic effects are mediated through multi-target modulation of the glutamatergic system. Unlike conventional antidepressants, ketamine exerts a markedly faster onset of action; however, its long-term safety profile and potential risk of...
Scientific ReportsMarch 27, 2026Gianmauro Palombelli, Valentina Zecca, Marta Boffa et al.1 citation
Major depressive disorder is highly prevalent and disabling, and many patients do not respond to standard therapies, resulting in treatment-resistant depression (TRD). Progress in TRD requires preclinical models with poor response to conventional treatments. The Wistar-Kyoto rat exposed to chronic mild stress (WKY/CMS) offers a robust paradigm: it shows limited responsiveness to standard...
Medicine AdvancesMarch 27, 2026Thomas Edward Cutting, Richard Evans Hartman
ABSTRACT Numerous studies have demonstrated the efficacy of (R, S)‐ketamine as a treatment for post‐traumatic stress disorder (PTSD), treatment‐resistant depression, and comorbid occurrences of these conditions. The (R) and (S) stereoisomers of ketamine have also demonstrated efficacy in attenuating stress and depressive symptoms, with (R)‐ketamine demonstrating reduced abuse potential and side...
Objective: This study aimed to investigate the intervention effects of cognitive behavioral therapy (CBT) combined with mindfulness training on emotional regulation ability and sleep quality in adolescents with depressive disorders, providing evidence for optimizing non-pharmacological intervention strategies for adolescent depression in clinical settings. Methods: A total of 200 adolescent...
Abstract Objectives This randomized controlled trial examined mechanisms underlying meditation-induced changes in self-related processes and compared attentional and deconstructive meditation. The objectives were to (1) examine whether components of selflessness mediate the effects of meditation on dysfunctional attitudes, identity threat, and depressive symptoms, and (2) compare the effects...
PsyArXivMarch 25, 2026Sam Malins, Cosmin Manolescu, Tim Sweeney et al.
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Mindfulness-Based Cognitive Therapy is a group psychological therapy that prevents relapse amongst people with recurrent depression. However, many people who attend MBCT do not fully benefit. This study assessed the feasibility, acceptability and initial clinical utility of personalised smart-messaging as an adjunct to remote Mindfulness-Based Cognitive Therapy (rMBCT) for recurrent depression...