Depression: all studies (page 41) - The Consciousness Library

Sustained effectiveness and safety of esketamine for major depressive disorder: a target trial simulation of real-world data.

Translational Psychiatry April 10, 2026 Ting-Hui Liu, Hong-Shiang Shen, Jheng-Yan Wu et al. 1 citation

This study aimed to evaluate the long-term effectiveness and safety of esketamine in adults with Major depressive disorder (MDD), focusing on suicide-related events, all-cause mortality, and major adverse cardiovascular events (MACEs). This target-trial simulation used the TriNetX Global Collaborative Network. Adults (≥ 18 years) with MDD who received either esketamine or a conventional...

DOI: 10.1038/s41398-026-04032-3 Full text Ketamine Major depressive disorder Humans Antidepressive agents +5

Evaluation of a facilitator training program in a randomized controlled trial of psilocybin treatment for depression.

BMC Medical Education April 9, 2026 Nikita Sanati Morel, Dea Siggaard Stenbæk, Johan Lundberg et al.

Major depression is a prevalent condition among patients with life-threatening illnesses, such as cancer, and recent findings suggest that psilocybin may hold promising treatment potential. Contemporary trials of psilocybin generally employ a model that includes psychotherapeutic support consisting of preparation and integration sessions surrounding the dosing. However, there is limited...

DOI: 10.1186/s12909-026-09124-8 Full text Psilocybin Cancer-related depression Facilitator training Nurses +4

Nightmares matter: rethinking suicide risk assessment and intervention in depression

Sleep April 8, 2026 Julia Maruani, Pierre A Geoffroy 2 citations

Nightmares are repeated and lengthy dreams, extremely dysphoric, with clear memory, typically involving life-threatening threats to safety or physical integrity. These nightmares lead to significant distress upon awakening and may substantially impact daytime functioning. Both the experience of these dreams and the sleep disruption produced by the ensuing awakening cause significant impairment...

DOI: 10.1093/sleep/zsag101 Major depressive disorder Depression economics Intervention counseling Suicide risk +7

From the body to the mind: interoception and sense of agency as mechanisms of depression reduction in the Body-Mind Axial Awareness (BMAA).

Frontiers in Psychology April 7, 2026 Yunn-Wen Lien, Shan-Chuan Teng, Li-Yun Wei

Introduction: Psychological wellbeing among young adults has declined globally, along with rising levels of depression, creating an educational and societal crisis and highlighting the urgent need for school-based mental health interventions. In response, the Body-Mind Axial Awareness (BMAA) method-an embodied body-mind enhancement program rooted in East Asian self-cultivation traditions-was...

DOI: 10.3389/fpsyg.2026.1755698 Full text Depression Mindfulness Emotion regulation Wellbeing +3

A Systematic Review and Meta-Analysis of the Efficacy and Safety of Intranasal Esketamine for Rapid Symptom Relief in Treatment-resistant Depression.

Reviews on recent clinical trials April 7, 2026 Ritika Saun, Aakriti Garg, Mohd Ashif Khan

Most of the Major Depressive Disorder (MDD) patients experience Treatment-Resistant Depression (TRD), wherein standard pharmaceutical and psychological interventions fail to provide adequate symptom relief. This systematic review and meta-analysis investigated the efficacy and safety of intranasal esketamine for rapid symptom relief in adults with TRD. The search strategy adhered to PRISMA...

DOI: 10.2174/0115748871407261251215071206 Full text Mdd Esketamine Major depressive disorder Severe depression +2

Effectiveness of mindfulness-based stress reduction in managing fatigue, anxiety, and depression among non-small cell lung cancer patients receiving surgery and adjuvant chemotherapy: A randomized controlled trial.

Medicine April 3, 2026 Xiaoqian Liu, Hui Chen, Yuna Cheng et al.

Non-small cell lung cancer (NSCLC) patients undergoing surgery and adjuvant chemotherapy often experience debilitating physical and psychological symptoms, including cancer-related fatigue, anxiety, and depression. Mindfulness-based stress reduction (MBSR) has emerged as a complementary intervention to alleviate these burdens and enhance quality of life, but evidence in NSCLC populations...

DOI: 10.1097/md.0000000000048134 Full text Anxiety Depression Cancer-related fatigue Mindfulness-based stress reduction +2

A systematic review on mindfulness-based immersive interventions in depressive disorders

npj Mental Health Research April 2, 2026 Peng Tan, Yuqi Wu, Xinrong Chen et al. 3 citations

Depressive disorders are characterized by persistent negative affect, rumination, and impaired emotion regulation, contributing substantially to global disease burden. As recurrent rumination and negative attentional biases are central cognitive mechanisms of depression, interventions targeting these processes have gained increasing attention. Mindfulness-based interventions (MBIs) effectively...

DOI: 10.1038/s44184-026-00205-6 Full text Anxiety Psychological intervention Rumination Neurocognitive +9

Nitrous oxide for late-life depression with inadequate antidepressant response: a randomised controlled trial.

EClinicalMedicine April 2, 2026 Antony Salamé, Samuel Bulteau, Gabriel Robert et al.

Background Late-life depression with inadequate antidepressant response is a pressing clinical issue with limited proven therapies. Nitrous oxide (N 2 O) may offer a new therapeutic avenue with rapid and safe antidepressant effects in late-life depression with inadequate antidepressant response. Methods We conducted a double-blind, randomised, placebo-controlled, single-dose trial (November...

DOI: 10.1016/j.eclinm.2026.103860 Full text

Esketamine prevents postpartum depression after cesarean section: a Meta-analysis

Yixue xinzhi zazhi April 2, 2026 Yao Wenzhuang, Zhang Hanyun, Liu Suman et al.

Objective To systematically evaluate the efficacy and safety of Esketamine on postpartum depression (PPD) in cesarean section women.Methods Databases including PubMed, Embase, Web of Science, The Cochrane Library, CBM, CNKI, WanFang and VIP were searched from inception to March 2025 for RCTs investigating the impact of Esketamine on PPD in cesarean section parturients. RevMan 5.4 and Stata 18.0...

DOI: 10.12173/j.issn.1004-5511.202505094 Full text Esketamine Cesarean section Postpartum depression Patient-controlled intravenous analgesia +1

Metabolomic Profiling of Extracellular Vesicles Reveals Distinct Metabolic Dysregulation and Treatment-Specific Signatures in Depression.

Biomolecules April 2, 2026 Nikola Balic, Gordana Nedic Erjavec, Marcela Konjevod et al.

Major depressive disorder (MDD) is associated with complex metabolic alterations. In this study, we applied a multiplatform metabolomics approach (GC-MS and LC-MS) to characterize the plasma extracellular vesicle (EV) metabolome in healthy controls (N = 50), responsive MDD patients (N = 60), and patients with treatment-resistant depression (TRD; N = 65). Longitudinal analyses were performed...

DOI: 10.3390/biom16040533 Full text Mdd Esketamine Trd Bright-light therapy +4