JMIR Research Protocols
October 27, 2022
Abigail Schweiger, Thomas L Rodebaugh, Eric J Lenze et al.
Precision medicine, optimized interventions, and access to care are catchphrases for the future of behavioral treatments. Progress has been slow due to the dearth of clinical trials that optimize interventions' benefits, individually tailor interventions to meet individual needs and preferences, and lead to rapid implementation after effectiveness is demonstrated. Two innovations have emerged...
International Journal of Molecular Sciences
October 13, 2022
Stephen M Stahl, Sara de Martin, Andrea Mattarei et al.
This article presents a mechanism of action hypothesis to explain the rapid antidepressant effects of esmethadone (REL-1017) and other uncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonists and presents a corresponding mechanism of disease hypothesis for major depressive disorder (MDD). Esmethadone and other uncompetitive NMDAR antagonists may restore physiological neural plasticity in...
Journal of Integrative and Complementary Medicine
October 2022
Jonathan Greenberg, Daphne Catherine Spyropoulos, Jafar Bakhshaie et al.
Mindfulness can help improve chronic pain outcomes. This cross-sectional study is the first to test associations between specific mindfulness facets and pain-related outcomes (pain intensity, pain-related disability, anxiety, and depression) in individuals with chronic orofacial pain (N = 303). "Nonjudging" was associated with positive pain-related outcomes. "Observing" was associated with...
Cureus
October 1, 2022
Dev B Goel, Sarju Zilate
24 citations
Psilocybin is a plant alkaloid that is derived from precursors of tryptamine and is present in many different types of mushrooms. It has been utilized by indigenous peoples of Central and South America for centuries in a ceremonial setting to promote spiritual experiences. Indigenous societies have long employed psilocybin and other 5-HT 2A agonist classic psychedelics in their rites. They were...
Behavioral Sciences
September 29, 2022
Jesse R Caswell, Aishwarya N Duggirala, Paul Verhaeghen
Background: We examined how a newly proposed facet of rumination, that is, the (in)ability to let go, might relate to other aspects of rumination and to psychological outcomes. Methods: In two independent samples (n = 423 and 329, resp.) of college students, we measured a broad set of rumination and rumination-related measures, letting go, anxiety and dysphoria; in the second sample, we also...
Neuropharmacology
September 15, 2022
S Ross, M Agrawal, Roland R. Griffiths et al.
69 citations
Psychiatric and existential distress commonly occur in advanced cancer and other serious, life-threatening or end-of-life medical illnesses and are associated with poor medical and psychiatric outcomes. Currently available treatment modalities in this patient population, including medication and psychotherapy, are limited in effectiveness, especially regarding existential distress. The lack of...
Journal of Technology in Behavioral Science
September 10, 2022
Jeyaseelan Maria Michael, Marc Eric S Reyes
The outbreak of the Covid-19 pandemic has led to the intensive use of the internet for educational and recreational purposes, leading adolescents to be more exposed to cyberbullying. Empirical studies indicate that cyberbullying has become a pervasive problem among adolescents causing negative consequences like depression. Moreover, the global pandemic lockdown and quarantine measures gave rise...
September 8, 2022
Adam Safron, Matthew Johnson
5 citations
preprint
Here we consider psychedelics with respect to their mechanisms of action, use, and implications for our understandings of brain and mind. This review is somewhat nontraditional in its scope, with discussions of both basic facts as well as theoretical speculations. We chose this approach given the unique historical context we find ourselves in at present. While we have decades of investigations...
Mindfulness
September 2022
Matthew J. Hirshberg, Blake A Colaianne, Mark Greenberg et al.
Significant concerns have been raised about the "mental health crisis" on college campuses, with attention turning to what colleges can do beyond counseling services to address students' mental health and well-being. We examined whether primarily first-year (89.1%) undergraduate students (n=651) who enrolled in the Art and Science of Human Flourishing (ASHF), a novel academic and experiential...
Epilepsy & Behavior
September 2022
Tina Makris, Diana S Dorstyn
Research on third-wave cognitive behavioral therapies has burgeoned over the last ten years. However, questions remain about the effectiveness of these therapies for people with epilepsy. This article provides an up-to-date review of the current evidence-base. Following protocol registration (PROSPERO CRD42021269882), two reviewers searched six databases (from inception until 1 March 2022) for...