Neuropharmacology
June 1, 2026
Nehal G. Fahmy, Nada M. Kamel, Mahmoud M. Khattab et al.
Doxorubicin (DOX), a widely utilized chemotherapeutic agent, is associated with significant adverse effects, including cognitive dysfunction (chemobrain) and depression. Ketamine (KET), the anesthetic, was off-label used as antidepressant and got FDA approval in 2019 for treatment-resistant depression management. Hence, this study investigated the therapeutic efficacy of single [KET(S)] versus...
JAMA Network Open
June 1, 2026
Martin Walter, Christine Zu Eulenburg, Ani Damyanova et al.
1 citation
Ketamine exerts rapid antidepressant effects. However, currently available ketamine-based treatments are associated with dissociative and cardiovascular adverse effects. To evaluate the antidepressant efficacy and tolerability of KET01, a novel, oral, prolonged-release racemic ketamine tablet formulation. KET01-03 was an active-comparator, double-blind, double-dummy, crossover phase 1...
European Archives of Psychiatry and Clinical Neuroscience
June 1, 2026
Ziping He, Yijie Wang, Jiemin Chen et al.
1 citation
BACKGROUND: Several recent trials indicate positive effects of psilocybin in patients with major depressive disorder. However, questions need to be addressed regarding the relationship between dosage and therapeutic outcomes, such as the recommended dose range and frequency for optimal practice as well as the dose-dependent adverse effects. OBJECTIVE: (1) to assess the effectiveness and...
Brain and Behavior
June 1, 2026
Christopher Poppe, Liisa Lyck, Laura Bechtold et al.
1 citation
Expectations strongly shape participant experiences in clinical trials, contributing to placebo effects that complicate interpretation of outcomes. While quantitative tools exist to measure expectations, their subjective and multidimensional nature, especially for individuals with treatment-resistant depression (TRD), remains underexplored. This study aimed to explore the motivations and...
Psychedelic Medicine
June 1, 2026
William E Rosa, Stephanie Napolitano, Natalie Mcandrew et al.
Psilocybin shows encouraging outcomes for patients with cancer and major depressive disorder (MDD). However, there is insufficient evidence on the use of evidence-based psychotherapeutic interventions to consistently guide and standardize psilocybin preparation, dosing, and integration. Meaning-centered psychotherapy (MCP) is a manualized, brief psychotherapeutic intervention that enhances...
medRxiv Preprint Server
May 31, 2026
Yves Martins Varela, Patrícia Cavalcanti-Ribeiro, Geovan Menezes de Sousa et al.
preprint
Background Ketamine has emerged as an effective rapid-acting treatment for treatment-resistant depression (TRD), producing significant antidepressant effects within hours of administration. Given ketamine’s capacity to induce states of heightened neuroplasticity and psychological openness, psychotherapy may represent a meaningful complement to its pharmacological effects — facilitating...
npj Mental Health Research
May 30, 2026
Kenni Wojujutari Ajele, Botho Nanvula Ramonkga, Matthew O Olasupo et al.
Anxiety, depression, and stress are common in individuals with diabetes and cancer and are associated with poor self-management and well-being. Cognitive behavioral therapy (CBT) and mindfulness-based interventions (MBIs) are widely used in nonpharmacological treatments, but their comparative effectiveness remains unclear. We conducted a stratified subgroup meta-analysis to indirectly compare...
Journal of Education and Development
May 29, 2026
Michiyo Ando, Hiroko Kukihara, Sayoko Ito
Background: Care wokers experience much stress becase of physical and emotional lavor. They often were hurted. Mindfulness yoga is one of the most useful intervention. Purpose: The purpose of this study was to investigate effects of mindfulness yoga on self-compassion, depression, resilience, and happiness of care workers. Method: Participants were 11 care workers consisting of nurses and...
Journal of Pain & Palliative Care Pharmacotherapy
May 29, 2026
Yogendra Singhal, Pavan Gaurav R, Sreeharsh Saji et al.
Depression is a common and serious concern in cancer patients, significantly impacting quality of life, treatment adherence, and overall prognosis. While traditional antidepressants often take weeks to exert therapeutic effects, ketamine has emerged as a potential alternative due to its rapid antidepressant action. This systematic review explores the efficacy, safety, and clinical role of...
Translational Psychiatry
May 29, 2026
Justyna K. Hinchcliffe, Katie Kamenish, Julia M. Bartlett et al.
Affective biases shape cognitive and emotional behaviour and are important in major depressive disorder (MDD). Modulation of affective biases by the NMDA antagonist, ketamine, may underlie its antidepressant effects but not all NMDA antagonists are efficacious. Some studies suggest ketamine's efficacy involves non-NMDA mechanisms e.g. via its active metabolite HNK (2R, 6R)-hydroxynorketamine),...