The World Journal of Biological Psychiatry
September 1, 2014
R. Lai, Natalie Katalinic, Paul Glue et al.
Abstract Objectives. Research studies have reported impressive antidepressant effects with ketamine but significant knowledge gaps remain over the best method of administering ketamine, and the relationships between dose, antidepressant response and adverse effects. Methods. In this pilot dose-finding study, the efficacy and tolerability of ketamine given by rapid intravenous (i.v.) infusion...
Mental Health Clinician
September 1, 2014
Ruki Wijesinghe
Despite new insights and evidence-based treatment options for clinical depression in the recent years, the current choices of safe and effective therapies are still inadequate to sustain a long-term response in the depressed patient. Many do not improve, improve partially or are classified as ‘treatment resistant’ with poor compliance and marked functional impairment. The aim of this article is...
History of Psychiatry
September 1, 2014
Herman Westerink
Contrary to the often-voiced opinion that the birth of modern psychiatry should be regarded as a victory of enlightened science and rationality over outdated religious beliefs and ecclesiastical authority, it is argued in this article that the emergence of medical and psychiatric approaches to pathology in modernity takes place in the context of intensified religious life and mutual rivalry...
BMC Complementary and Alternative Medicine
August 19, 2014
Z. Amtul, Amanda Arena, H. Hirjee et al.
BackgroundThe prevalence and socioeconomic cost of late life depression (LLD) is on the rise, while the response rate to antidepressant trials remains poor. Various mind-body therapies are being embraced by patients as they are considered safe and potentially effective, yet little is known regarding the effectiveness of such therapies to improve LLD symptoms. Among the mind-body therapies...
Frontiers in Human Neuroscience
August 19, 2014
Eva Henje Blom, Larissa G Duncan, Tiffany C Ho et al.
Major depressive disorder (MDD) is one of the current leading causes of disability worldwide. Adolescence is a vulnerable period for the onset of depression, with MDD affecting 8-20% of all youth. Traditional treatment methods have not been sufficiently effective to slow the increasing prevalence of adolescent depression. We therefore propose a new model for the treatment of adolescent...
Psycho-Oncology
August 17, 2014
Shelley A Johns, Linda F. Brown, Kathleen A Beck-Coon et al.
Objective: Cancer-related fatigue (CRF) is one of the most common, persistent, and disabling symptoms associated with cancer and its treatment. Evidence-based treatments that are acceptable to patients are critically needed. This study examined the efficacy of mindfulness-based stress reduction (MBSR) for CRF and related symptoms. Method: A sample of 35 cancer survivors with clinically...
Clinical Psychopharmacology and Neuroscience
August 1, 2014
Aparna P. Shah, F. Carreño, A. Frazer
Treatment resistant depression (TRD) is a global health concern affecting a large proportion of depressed patients who then require novel therapeutic options. One such treatment option that has received some attention in the past several years is vagal nerve stimulation (VNS). The present review briefly describes the relevance of this treatment in the light of other existing pharmacological and...
Therapeutic Advances in Psychopharmacology
August 1, 2014
David Baumeister, Georgina Barnes, Giovanni Giaroli et al.
Hallucinogens have been part of spiritual practice for millennia, but controversy surrounding their mind-manifesting effects led to their proscription by the mid-20th century, largely without evidence of harm or toxicity and despite nascent data suggesting therapeutic utility in treating depressive illnesses. This review explores their pharmacodynamic actions and the current limited data on...
Psychopharmacology
July 24, 2014
Ruin Moaddel, D. Luckenbaugh, Ying Xie et al.
(R,S)-ketamine is a rapid and effective antidepressant drug that produces a response in two thirds of patients with treatment-resistant depression (TRD). The underlying biochemical differences between a (R,S)-ketamine responder (KET-R) and non-responder (KET-NR) have not been definitively identified but may involve serine metabolism. The aim of the study was to examine the relationship between...
International Journal of Transpersonal Studies
July 1, 2014
Philip E. Wolfson
7 citations
NA
Child and Adolescent Psychiatric Clinics of North America
July 1, 2014
Deborah R Simkin, Nancy B. Black
This article describes the various forms of meditation and provides an overview of research using these techniques for children, adolescents, and their families. The most researched techniques in children and adolescents are mindfulness-based stress reduction, mindfulness-based cognitive therapy, yoga meditation, transcendental meditation, mind-body techniques (meditation, relaxation), and...
International Journal of Transpersonal Studies
July 1, 2014
Philip E. Wolfson
2 citations
Prior studies have reported variously on the presence or absence of dissociative effects at subanesthtetic doses of ketamine administered for treatment-resistant depression. This mixedmethods study emulated the protocol used for the studies in question, with IV administration of 0.5mg/kg over 40 minutes with eight experienced ketamine users. Quantitative measures were generally insignificant...
International Journal of Transpersonal Studies
July 1, 2014
Wesley C Ryan, Cole Marta, Ralph J. Koek
5 citations
Ketamine, via intravenous infusions, has emerged as a novel therapy for treatment-resistant depression, given rapid onset and demonstrable efficacy in both unipolar and bipolar depression. Duration of benefit, on the order of days, varies between these subtypes, but appears longer in unipolar depression. A unique property is reduction in suicidality although data are more limited. Strategies to...
Pharmacopsychiatry
June 23, 2014
Nancy B. Lundin, Mark J. Niciu, David A. Luckenbaugh et al.
17 citations
INTRODUCTION: Deficiencies in both vitamin B12 and folate have been associated with depression. Recently, higher baseline vitamin B12 levels were observed in individuals with bipolar depression who responded to the antidepressant ketamine at 7 days post-infusion. This study sought to -replicate this result by correlating peripheral vitamin levels with ketamine's antidepressant efficacy in...
Journal of Psychopharmacology
June 1, 2014
Peter R Diamond, Andrew D Farmery, Stephanie Atkinson et al.
Background: Ketamine has a rapid antidepressant effect in treatment-resistant depression (TRD). The effects on cognitive function of multiple ketamine infusions and of concurrent antidepressant medication on response rate and duration are not known. Method: Twenty-eight patients with uni- or bipolar TRD were treated over three weeks with either three or six ketamine infusions (0.5 mg/kg over 40...
Implementation Science
May 24, 2014
J. Rycroft-Malone, R. Anderson, R. Crane et al.
BackgroundMindfulness-based cognitive therapy (MBCT) is a cost-effective psychosocial prevention programme that helps people with recurrent depression stay well in the long term. It was singled out in the 2009 National Institute for Health and Clinical Excellence (NICE) Depression Guideline as a key priority for implementation. Despite good evidence and guideline recommendations, its roll-out...
Frontiers in Human Neuroscience
May 22, 2014
Marieke Karlijn van Vugt, Peter eHitchcock, Ben eShahar et al.
Objectives: Converging research suggests that mindfulness training exerts its therapeutic effectson depression by reducing rumination. Theoretically, rumination is a multifaceted construct thataggregates multiple neurocognitive aspects of depression, including poor executive control,negative and overgeneral memory bias, and persistence or stickiness of negative mind states.Current measures of...
The Journal of Clinical Psychiatry
May 15, 2014
Mark J. Niciu, David A. Luckenbaugh, Dawn F. Ionescu et al.
167 citations
OBJECTIVE: The N-methyl-D-aspartate receptor antagonist ketamine has rapid antidepressant effects in treatment-resistant major depressive disorder (MDD) and bipolar depression. Clinical predictors may identify those more likely to benefit from ketamine within clinically heterogeneous populations. METHOD: Data were analyzed from 4 studies of treatment-resistant inpatients with...
Clinical Psychology & Psychotherapy
May 7, 2014
Manjit K Khalsa, Julie M Greiner-Ferris, Stefan G Hofmann et al.
Cognitive behavioural therapy (CBT) is an effective treatment for generalized anxiety disorder, but there is still room for improvement. The aim of the present study was to examine the potential benefit of enriching CBT with kundalini yoga (Y-CBT). Participants consisted of treatment resistant clients at a community mental health clinic. A total of 32 participants enrolled in the study and 22...
The Journal of Alternative and Complementary Medicine
May 1, 2014
Susaree Prakhinkit, Siriluck Suppapitiporn, Hirofumi Tanaka et al.
The objectives of this study were to determine the effects of the novel Buddhism-based walking meditation (BWM) and the traditional walking exercise (TWE) on depression, functional fitness, and vascular reactivity. This was a randomized exercise intervention study. The study was conducted in a university hospital setting. Forty-five elderly participants aged 60-90 years with mild-to-moderate...