Scientific ReportsMay 21, 2026Amy Z Wang, Carissa W Tomas, Sarah Stevens et al.
Research has identified functional connectivity abnormalities in the default mode network (DMN), a functional brain network theorized to be involved in self-referential processes, among trauma survivors. Event centrality (EC) is an important cognitive component of posttrauma stress disorder (PTSD) development that heavily involves self-referential processing and autobiographical memory....
Research SquareMay 11, 2026Xiaoming Yang, Jian Lyu, Jubo Wang et al.
preprint
Mild cognitive impairment (MCI) is a critical prodromal stage of progressive cognitive decline. As a core cognitive brain network, the default mode network (DMN) exhibits structural alterations in MCI that are closely associated with cognitive impairment. Apolipoprotein E ε4 (APOE ε4), the strongest genetic risk factor for pathological cognitive decline, has been shown to disrupt the structural...
There are several methodological as well as analytical problems regarding the work published by Pan et al. examining DMN and SN disturbances in mild cognitive impairment with neuropsychiatric features. It found significant changes in functional connectivity associated with behavioral symptoms. However, a few points require additional elucidation including confirmation via longitudinal design,...
Episodic memory involves reconstruction of past events through integration of multiple types of information, including perceptual details, narrative content, and emotional tone. The default mode network (DMN) is a set of regions thought to support episodic retrieval, yet it remains unclear how distinct subnetworks contribute to recall of these different memory features. Here, we examined how...
Abstract: This study investigates intelligence-related differences in the adjustment of brain activity and connectivity to varying cognitive demands, testing for a moderation of an association between intelligence and neural efficiency by task difficulty. In 72 young adults (34 female, 38 male), fMRI brain activity changes during a decision-making task with five levels of difficulty were...
Learned spatial regularities can reduce attentional capture by salient distractors, but observers vary in how strongly such regularities shape distractor interference. We asked whether this variability is associated with default mode network (DMN) functional connectivity, a network measure linked to individual differences in attention, internally guided cognition, and contextual memory. Using...
Social interactions are critical for mental health and are frequently disrupted in neuropsychiatric disorders. Clinical data suggest a link between dysfunction of the default mode network (DMN) and social impairment. To advance our understanding of the neurobiological mechanisms underlying social dysfunction, we back-translate these clinical findings into a preclinical setup, demonstrating that...
Water-based contemplative practices—from full-body underwater meditation to ice baths, breath-hold training, and mindful immersion near lakes or oceans—are associated with profound psychological and physiological benefits. While most mindfulness literature emphasizes silencing the Default Mode Network (DMN), emerging evidence suggests a more nuanced truth: the DMN does not need to be turned...
Introduction: Self-referential processes are suspected to rely on the default mode network (DMN), particularly the posterior cingulate cortex (PCC). The right PCC, has been implicated in self-awareness, with neuroimaging studies showing its involvement in anosognosia in Alzheimer’s disease. However, causal evidence linking right PCC activity to DMN synchrony in humans remains scarce. This study...
NeuroimageApril 22, 2026Kia Puustinen, Jitske Vandersmissen, Tin Gojevic et al.
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder linked to an increased risk for neurodegeneration and cognitive impairment. The current study set out to explore a wide range of indirect markers of neuronal function via proton magnetic resonance spectroscopy (1H-MRS) to help elucidate the link between altered glucose metabolism and neurodegeneration. Method: Adults...