Neuroimage
March 25, 2026
Fabrizio Parente, Tiziana Pedale, Ilenia Salsano et al.
The Default Mode Network (DMN) is a large-scale intrinsic brain network critically involved in internally oriented cognition, including autobiographical memory. Core DMN regions such as the hippocampus and medial prefrontal cortex are central to memory retrieval, schema construction and self-referential processing. Individuals with Highly Superior Autobiographical Memory (HSAM) provide a unique...
bioRxiv
March 17, 2026
Victor Altmayer, Sarah Moreno-Rodriguez, Marcela Ovando-Tellez et al.
preprint
Creativity is a hallmark of human cognition, characterized by the ability to connect seemingly distant concepts or ideas. Existing theories suggest that remote thinking can be achieved either spontaneously (constrained by the structure of semantic memory) or in a goal-directed manner (constrained by a creative goal). The present study investigates the neural correlates of goal-directed remote...
Current Opinion in Behavioral Sciences
March 16, 2026
What episodic memory reveals about the default mode network.
BMC Complementary Medicine and Therapies
March 16, 2026
Xing-Chen Zhou, Shuang Wu, Kai-Zheng Wang et al.
OBJECTIVE: To analyze the brain functional network remodeling associated with the relief of negative emotions in patients with lumbar disc herniation (LDH) treated with lever positioning manipulation (LPM) using resting-state fMRI (rs-fMRI) technology. METHODS: A prospective study included LDH patients (Group 1, n = 47) and age- and gender-matched healthy controls (Group 2, n = 43). Group 1...
PLoS Biology
March 10, 2026
Ali Rezaei, Corson N. Areshenkoff, Daniel J. Gale et al.
Motor learning induces alterations in neural activity that can persist long after the effects of such learning have faded. These persistent neural alterations are thought to manifest behaviorally as "savings," or faster relearning, via access to a latent motor memory. How the human brain forms and retrieves these latent memories, and the specific neural systems involved, remains unresolved....
March 3, 2026
Kristina Schwarz
preprint
Background: The Default Mode Network (DMN) is consistently implicated in self-referential thinking and rumination and shows altered functioning in depression and anxiety disorders. The Attention Training Task (ATT), a core technique in metacognitive therapy, aims to reduce internally directed attention by enhancing flexible attentional control. While previous neuroimaging studies have...
Brain Imaging and Behavior
February 28, 2026
Ziwei Yang, Xiao Liang, Yuqi Ji et al.
Pain-induced reorganization of the default mode network (DMN) exhibits distinct temporal signatures in the acute and chronic stages, yet the mechanistic interplay between static/dynamic network topology and pain chronicity remains unclear. In this study, we utilized both static and dynamic graph theory analyses to characterize DMN reconfiguration in 50 patients with low back-related leg pain...
Cognitive, Affective, & Behavioral Neuroscience
February 20, 2026
James B Wyngaarden, Akanksha Nambiar, Jeffrey Dennison et al.
Individuals vary substantially in their responses to rewarding events and their motivation to pursue rewards. While the ventral striatum (VS) plays a central role in reward anticipation, its functional connectivity with the default mode network (DMN)-critical for self-referential processing and value integration-potentially represents a key mechanism through which trait differences manifest in...
Neuroscience Letters
February 16, 2026
Hamide Nasiri, Behdad Mohammadtaheri, Farbod Khosravi et al.
Disruptions in default mode network (DMN) connectivity are well documented in Alzheimer's disease (AD), yet their associations with specific cognitive domains remain unclear. This study examined relationships between anterior and posterior DMN functional connectivity and memory, executive function, and language performance across the AD continuum. We conducted a cross-sectional analysis of...
Cortex
February 14, 2026
David Kemmerer, Guy Dove
The Default Mode Network (DMN) is a collection of interconnected transmodal cortical areas that was originally found to be engaged when people do not focus on external sensory stimuli but instead attend to their inner thoughts. More recent experiments have shown that it is also recruited during externally oriented tasks that require the processing of concepts, including the increasingly complex...