Treatment-resistant depression (TRD) accounts for approximately 30% of major depressive disorder cases and has been characterized by altered functional connectivity within and between the Default Mode (DMN) and Frontoparietal networks (FPN). Ketamine can be an effective treatment for TRD, and its antidepressant response has been associated with alterations in resting state functional...
Introdução: A interface entre espiritualidade e neurociência tem se consolidado como campo transdisciplinar capaz de iluminar processos de autoconsciência, autorreferência e produção de sentido, sem reduzir a experiência humana a localizações cerebrais isoladas. Objetivo: Analisar, por meio de revisão bibliográfica integrativa, como redes neurais associadas ao self e à cognição social sustentam...
This proposal presents a framework for understanding consciousness based onempirical observation of stable Type 1 consciousness in an adult subject over sevenyears. We propose that what neuroscience currently studies as ‘consciousness’ mayprimarily be automated cognitive processing (Type 2), while phenomenal awarenessitself (Type 1) operates through fundamentally different mechanisms. Key...
Background: Depression in children is a concerning societal issue and can be associated with poor academic performance, school dropout, and poor overall quality of life. Additionally, child depression is often associated with parallel stress and depression in parents. Objective: This scenario highlights the urgent need for the development and implementation of accessible and scalable solutions...
Introdução: A depressão resistente ao tratamento (DRT) exige novas abordagens que superem a limitação dos antidepressivos convencionais. O renascimento dos psicodélicos, especialmente da psilocibina, surge como uma alternativa promissora baseada na modulação da neuroplasticidade. Metodologia: Revisão integrativa da literatura realizada em bases de dados científicas (PubMed, SciELO, LILACS), com...
Psychedelic substances like ayahuasca, psilocybin, and LSD have been used for thousands of years in spiritual ceremonies, with users often reporting transcendent and life-altering experiences. Chapter 8 traces the arc of psychedelic use from ancient rituals and colonization to the countercultural revolution and modern neuroscience labs. The chapter blends cultural history with...
Dissociation, an altered state of consciousness in which individuals feel detached from their body, environment, and sense of self, is a common feature of posttraumatic stress disorder (PTSD). Despite its significance, the neurocognitive processes underlying dissociation remain poorly understood, potentially limiting diagnostic precision and treatment efficacy in PTSD. To address this gap, we...
Meditation is a family of self-regulation exercises that train attention and awareness and produce measurable neurobiological adaptations, including increased cortical thickness in the left hippocampus and posterior Cingulate Cortex and enhanced functional connectivity between the prefrontal cortex and the default mode network, which reflects improved emotional regulation and neuroplasticity....
This chapter explores one of the biggest puzzles in meditation: if science is clear about its benefits, why do so many people struggle to do it regularly? Just like exercise, where most people know it’s good for them but fail to keep up with it, meditation faces the same gap between knowledge and practice. This chapter explains that one major reason is how our brains are wired. Our Default Mode...
The concept of timing is an interesting way to understand how the body and brain construct the concept of self, but also how self-distortions arise in the case of psychosis. Analysis of temporal representations in psychosis highlights a deficit that includes both the subjective experience of the flow of time, i.e., time perception, and the ability to process temporal information inherent to any...