NeuropsychopharmacologyOctober 1, 2025Andrew Jin Soo Byun, Harshawardhan U Deshpande, Jessi Stover et al.
Adolescent cannabinoid exposure has been implicated in enduring modifications to adult brain circuitry; however, well-controlled, systematic analyses investigating dose-dependent effects of chronic delta-9-tetrahydrocannabinol (THC) exposure on brain connectivity are lacking. It is hypothesized that large-scale intrinsic networks, such as default mode (DMN), central executive (CEN), and...
Acute cannabis exposure can transiently impair cognitive performance, increasing the risk of accidental injury and potentially disrupting activities of daily living. Although sex differences in responses to cannabis have been reported, no systematic review has examined whether these extend to acute cognitive effects. Our primary aim was to examine sex differences in the acute effects of...
Rapid changes in the legalized cannabis market have led to the predominance of high-concentration delta-9-tetrahydrocannabinol (THC) cannabis products. To systematically review associations of high-concentration THC cannabis products with mental health outcomes. Ovid MEDLINE through May 2025; EMBASE, Allied and Complementary Medicine Database, Cochrane Library, Database of Abstracts of Reviews...
ABSTRACT Background: Cannabis consumption is common among young adults with First Episode Psychosis (FEP). Mental health professionals tend to discourage its use due to concerns around symptom exacerbation and negative social outcomes. However, young adults report using cannabis for social and relational enhancement purposes. This study investigates the social aspects of cannabis use in service...
The Cannabinoid 1-receptor (CB1R) is found in particularly high levels in the hippocampus (HPC), increased CB1R density and binding observed in patients with schizophrenia, and epidemiological studies suggest that regular cannabis use during adolescence is a risk factor for the disease. Historically, concerns around adolescent marijuana use focused on the development of psychosis later in life,...
CureusSeptember 20, 2025Jaisingh Rajput, Sandhya Narahari, Taha Bin Arif et al.1 citation
The rising use of cannabis in the medical field has prompted the revival of the global debate about its psychotropic effects, especially when it comes to schizophrenia, a debilitating mental disorder that afflicts approximately 20 million people around the globe. Although Δ9-tetrahydrocannabinol (THC) is commonly considered a risk factor for psychosis, cannabidiol (CBD) has been studied for its...
Delta-9-Tetrahydrocannabivarin (THCV), a naturally occurring cannabinoid and structural analog of THC, exhibits a dual pharmacological profile as a CB1 receptor agonist/antagonist and a partial CB2 agonist. This study evaluated the effects of THCV in a THC discrimination model in rats. Male Sprague-Dawley rats (n = 16, 300–340 g, PND60) were trained under a fixed ratio 20 (FR20) schedule to...
Abstract Background Self-transcendent and mystical experiences may be key mechanisms underlying psychedelics’ therapeutic effects, yet how these experiences differ across substances remains unclear. This study compared mystical and self-transcendent experiences across psilocybin, 3,4-Methylenedioxymethamphetamine (MDMA), and cannabis in a diverse, community-based sample, while accounting for...
AbstractBackground and ObjectivesCannabis use is associated with psychotic disorder onset and exacerbation. This study examines how continued cannabis use affects depressive symptoms, psychotic symptoms, and suicidal behaviors following cannabis‐induced first‐episode psychosis (FEP).MethodsSixty‐five participants (aged 16–50 years) with FEP were recruited from psychiatric inpatient facilities...
Cannabis use has long been associated with enhanced music experiences, yet scientific research on its effects on auditory perception remains limited. This convergent mixed-methods self-report study investigated how recreational cannabis users experience auditory stimulation and music in particular. A total of 104 participants completed an online questionnaire, 15 of which were selected to...