Cannabis products premixed with caffeine are increasingly present in the United States marketplace. Despite emergence of this product class, no human laboratory data have directly evaluated the isolated impact of caffeine on Δ9-tetrahydrocannabinol (Δ9-THC) effects as well as additional impacts of other common co-administered cannabinoids. This double-blind, randomized, placebo-controlled,...
Legalisation of Cannabis use has led to considerable increases in the availability and potency of Cannabis products, as well as evolving patterns in methods of their consumption. Adolescent Cannabis use has increased, which can impair cognitive function during this critical developmental stage. The persistence of such effects into adulthood, however, is unclear. The present study examined...
Cannabis is the most widely used illicit substance globally, with an estimated 244 million people reporting its use in 2025. Cannabis remains the most widely used illicit substance globally, and its increasing prevalence among adolescents has raised critical public health concerns due to heightened neurodevelopmental vulnerability during this stage. In this review, we will attempt to explore...
This paper is an ethnographic description of cannabis use in a Canadian Inuit settlement. Cannabis is pervasive in Inuit communities, and both Inuit and public health authorities see it as a serious health and social problem. There is a general understanding that Inuit smoke cannabis to cope with stressors, but little investigation why Inuit choose cannabis instead of other options for managing...
Background The impact of acute cannabis exposure on brain function and cognitive performance varies among individuals. Acute effects of cannabis on behavior may be absent or benign in chronic users, while occasional users experience significant impairment in day-to-day operations. It is hypothesized that repeated cannabis use induces neuroadaptations leading to tolerance and desensitization,...
Cannabis is often consumed in polysubstance contexts, yet research comparing its isolated use to polydrug use is limited. Such comparisons are essential for understanding substance-specific versus interactive effects on brain activity. This study investigates how cannabis-only and polydrug use relate to alterations in resting-state EEG functional connectivity, using the Directed Transfer...
Abstract: Background: The use of cannabis in adolescence and early adulthood, critical phases for brain development, is linked to psychotic-like experiences (PLEs). The underlying mechanisms, however, remain unclear. This research examined the relationship between recreational cannabis use and PLEs, emphasizing the connectivity of the salience network (SN), which plays a role in salience...
Clinical and pre-clinical evidence demonstrates that adolescent Δ-9-tetrahydrocannabinol (THC) exposure, the primary psychoactive component of cannabis, increases the risk of developing neuropsychiatric symptoms in later life. The medial prefrontal cortex (mPFC) serves as a pathophysiological nexus point underlying many cannabis-related pathophysiological outcomes. Nevertheless, the molecular...
NeuropsychopharmacologyOctober 2025Aidan L Pham, Ashley E Marquardt, Kristen R Montgomery et al.
Cannabis is the most frequently used illicit drug during pregnancy, with use steadily increasing in the United States as legalization and decriminalization expand to more states. Many pregnant individuals use cannabis to reduce adverse symptoms of pregnancy, considering it to be less harmful than other pharmaceuticals or alcohol. The primary psychoactive component of cannabis,...
PsychopharmacologyOctober 2025Tanya Capolicchio, Giovanni Hernandez, Sammy Shun Wai Shi et al.
The increasing exposure to delta 9-tetrahydrocannabinol (THC) in youth sparks concerns about disruption of ongoing neurodevelopment. During adolescence, dopamine axons continue to grow from the striatum to the prefrontal cortex, promoting the refinement of inhibitory control. This process is coordinated by the Netrin-1 receptor, DCC, which is regulated by microRNA miR-218. In addition,...