Neurosciences
2007
B. Issa
Cannabis is one of the oldest, and one of the most widely abused substances. It is available in all parts of the world where it is used commonly as a recreational drug when smoked or consumed in some other ways. It also has some medicinal potential, the reason for which some are calling for its legalization. Cannabis has been associated with several psychiatric problems such as anxiety...
Learning & Memory
2007
Alexander F. Hoffman, Murat Oz, Ruiqin Yang et al.
preprint
Memory deficits produced by marijuana arise partly via interaction of the psychoactive component, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), with cannabinoid receptors in the hippocampus. Although cannabinoids acutely reduce glutamate release and block hippocampal long-term potentiation (LTP), a potential substrate for learning and memory, the consequences of prolonged exposure to...
Schizophrenia Research
December 1, 2006
Dagmar Koethe, Christoph W Gerth, Miriam A Neatby et al.
Recent data on alterations of the endogenous cannabinoid system in schizophrenia have raised the question of its functional role in this disease. The psychoactive compound of Cannabis sativa, delta-9-tetrahydrocannabinol (Delta9-THC), has been shown to induce psychotic symptoms, but it is unknown to what extend prodromal states of psychoses are reflected by these experimental approaches. This...
Neuroscience Letters
November 20, 2006
Duncan Ryan, Alison J Drysdale, Roger G Pertwee et al.
We have shown previously that the plant cannabinoid cannabidiol (CBD) elevates intracellular calcium levels in both cultured hippocampal neurones and glia. Here, we investigated whether the main psychotropic constituent of cannabis, Delta(9)-tetrahydrocannabinol (THC) alone or in combination with other cannabis constituents can cause similar responses, and whether THC affects the responses...
Experimental and Clinical Psychopharmacology
November 2006
Jennifer T Sneider, Harrison G. Pope, Marisa M Silveri et al.
The quantitative measurement of cerebral perfusion is crucial for the study of both normal and impaired human brain function. Although cannabis is the most commonly abused illicit substance in the United States, its effects on cerebral blood volume (CBV) have not been fully examined. The objective of the present study was to examine differences in relative regional blood volume in focal regions...
American Journal of Psychiatry
October 2006
Patrick D. Skosnik, Giri P Krishnan, Erin E Aydt et al.
Cannabis use may produce neurophysiological disturbances similar to those observed in schizophrenia, particularly in relation to altered neural synchronization. Therefore, the current experiment examined the effect of cannabis use on EEG neural synchronization using the auditory steady-state evoked potential. Auditory steady-state evoked potentials were assessed using varying rates of...
Pot Politics
September 21, 2006
Elliot N. Dorff
Abstract: This chapter approaches the issue of marijuana use from a Jewish perspective. The Torah demands that Jews become “a kingdom of priests and a holy nation.” The Jewish tradition uses wine to sanctify holidays and marriages; it does not use marijuana for those purposes. Still, Judaism allows Jews to ingest many things that are not intrinsically holy as part of the effort to fulfill the...
Anthropology of Consciousness
September 1, 2006
Jörg Fachner
Cannabis is known to change auditory perception and music appreciation as many musicians and music listeners report in narratives, interviews and biographies. An ethnographic pre/post study was conducted in a habituated naturalistic setting, combining qualitative and quantitative methods with four single case studies. Physiological results were gained with a mobile bedside EEG imaging machine...
The British Journal of Psychiatry
August 1, 2006
Leanne M Hides, Sharon Dawe, David J. Kavanagh et al.
BackgroundCannabis use appears to exacerbate psychotic symptoms and increase risk of psychotic relapse. However, the relative contribution of cannabis use compared with other risk factors is unclear. The influence of psychotic symptoms on cannabis use has received little attention.AimsTo examine the influence of cannabis use on psychotic symptom relapse and the influence of psychotic symptom...
The Canadian Journal of Psychiatry
August 1, 2006
Wayne Hall, Louisa Degenhardt
Objective: To explore the implications for mental health services, for health education about the risks of cannabis use, and for public policy toward cannabis use of observational evidence that cannabis use is a contributory cause of psychosis. Method: Using comparative analyses of similar evidence for the harmful effects of alcohol, tobacco, and amphetamine use, we considered the relation...