Psychotic symptom and cannabis relapse in recent-onset psychosis
Leanne M Hides, Sharon Dawe, David J. Kavanagh, R. M. Young
The British Journal of Psychiatry August 1, 2006 DOI: 10.1192/bjp.bp.105.014308 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 84 |
| Population | Participants with recent-onset psychosis assessed at hospital admission |
| Duration | 6-month follow-up |
| Topics | Cannabis |
| Key findings | Higher cannabis use frequency predicted psychotic relapse after controlling for confounders, and increased psychotic symptoms predicted cannabis relapse, with medication adherence reducing cannabis relapse risk. The authors propose a bidirectional relationship between cannabis use and psychosis. |
Abstract
BackgroundCannabis use appears to exacerbate psychotic symptoms and increase risk of psychotic relapse. However, the relative contribution of cannabis use compared with other risk factors is unclear. The influence of psychotic symptoms on cannabis use has received little attention.AimsTo examine the influence of cannabis use on psychotic symptom relapse and the influence of psychotic symptom severity on relapse in cannabis use in the 6 months following hospital admission.MethodAt baseline, 84 participants with recent-onset psychosis were assessed and 81 were followed up weekly for 6 months, using telephone and face-to-face interviews.ResultsA higher frequency of cannabis use was predictive of psychotic relapse, after controlling for medication adherence, other substance use and duration of untreated psychosis. An increase in psychotic symptoms was predictive of relapse to cannabis use, and medication adherence reduced cannabis relapse risk.ConclusionsThe relationship between cannabis use and psychosis may be bidirectional, highlighting the need for early intervention programmes to target cannabis use and psychotic symptom severity in this population.
Comparable studies
Other observational and cohort studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| High-potency cannabis and the risk of psychosis People with first episode of psychosis and healthy controls from the local population | 2009 | Case-control study | n = 454 |
| Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada Rural aboriginal population | 2013 | Observational study | |
| Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) Otherwise healthy young people | 2000 | Observational | |
| Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study Individuals from the general population in Germany aged 14-24 at baseline | 2011 | Observational cohort | n = 1,923 |
| Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases Patients treated for cannabis-induced psychotic symptoms in Denmark between 1994 and... | 2005 | Observational cohort | n = 535 |
Citations in the library
Cited by 21
- Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing Archives of General Psychiatry 2009
- Effects of cannabis use on outcomes of psychotic disorders: systematic review The British Journal of Psychiatry October 31, 2008
- Pathways from Cannabis to Psychosis: A Review of the Evidence Frontiers in Psychiatry 2013
- Course of cannabis use and clinical outcome in patients with non-affective psychosis: a 3-year follow-up study Psychological Medicine February 5, 2015
- Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms International Journal of Environmental Research and Public Health November 30, 2021
and 16 more in the library
Cites 3
- Cannabis use and outcome of recent onset psychosis European Psychiatry June 1, 2005
- Effects of cannabis and psychosis vulnerability in daily life: an experience sampling test study Psychological Medicine 2003
- Cannabis consumption as a prognostic factor in schizophrenia. The British Journal of Psychiatry May 1994