ACS Chemical Neuroscience
October 17, 2023
Hideaki Yano, Rezvan Chitsazi, Christopher Lucaj et al.
12 citations
The emergence of synthetic cannabinoid receptor agonists (SCRAs) as illicit psychoactive substances has posed considerable public health risks, including fatalities. Many SCRAs exhibit much higher efficacy and potency compared with the phytocannabinoid Δ 9 -tetrahydrocannabinol (THC) at the cannabinoid receptor 1 (CB1R), leading to dramatic differences in signaling levels that can be toxic. In...
ACS Chemical Neuroscience
April 23, 2020
Hideaki Yano, Pramisha Adhikari, Sett Naing et al.
26 citations
The nonmedical (i.e., recreational) misuse of synthetic cannabinoids (SCs) is a worldwide public health problem. When compared to cannabis, the misuse of SCs is associated with a higher incidence of serious adverse effects, suggesting the possible involvement of noncannabinoid sites of action. Here, we find that, unlike the phytocannabinoid Δ9-tetrahydrocannabinol, the indole-moiety containing...
Addiction Biology
January 5, 2016
Alexander F. Hoffman, Matthew D. Lycas, Jakub Kaczmarzyk et al.
39 citations
Abstract There has been a marked increase in the availability of synthetic drugs designed to mimic the effects of marijuana. These cannabimimetic drugs, sold illicitly as ‘Spice’ and related products, are associated with serious medical complications in some users. In vitro studies suggest that synthetic cannabinoids in these preparations are potent agonists at central cannabinoid CB1 receptors...
Learning & memory (Cold Spring Harbor, N.Y.)
2007
Alexander F. Hoffman, Murat Oz, Ruiqin Yang et al.
preprint
Memory deficits produced by marijuana arise partly via interaction of the psychoactive component, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), with cannabinoid receptors in the hippocampus. Although cannabinoids acutely reduce glutamate release and block hippocampal long-term potentiation (LTP), a potential substrate for learning and memory, the consequences of prolonged exposure to...
The Journal of neuroscience : the official journal of the Society for Neuroscience
June 15, 2003
Alexander F Hoffman, Murat Oz, Tara Caulder et al.
The rewarding properties of the psychoactive constituents of marijuana, termed "cannabinoids," may reflect actions on synaptic transmission in the nucleus accumbens (NAc). Furthermore, long-term changes in these synapses may support the addictive process. Excitatory and inhibitory synapses are acutely inhibited by cannabinoids in the NAc, and endogenous cannabinoids (endocannabinoids) play a...