Upwards of 50% of people do not respond to the primary treatment modalities for major depressive disorder (MDD), which has led to increased attention and use of alternative methods, including exercise and psychedelics. While interventions using either exercise or psychedelics have demonstrated largely positive results in isolation, their synergistic potential has yet to be explored. As such,...
MedicineMarch 6, 2026Hongfei Xiong, Yingxue Xu, Jiayi Liu et al.
This study demonstrates the efficacy of single-dose esketamine regimens, administered orally (ED95: 8.2125 mg/kg; 95% CI: 7.4250-8.4597 mg/kg) and intranasally (ED95: 2.1770 mg/kg; 95% CI: 2.0952-2.1958 mg/kg), in mitigating preoperative anxiety within a pediatric population. These findings highlight the safety and efficacy of esketamine for this patient group.
Stress and HealthMarch 5, 2026A. G. Little, Matthew J. Stainer, Alex Sandy MacQuarrie et al.1 citation
Paramedicine students experience disproportionately high rates of anxiety, depression, stress, and insomnia compared to the general population, placing them at risk of post-traumatic stress disorder and long-term psychological distress. Breathwork has emerged as a promising self-regulation intervention that may enhance resilience and wellbeing while reducing symptoms of mental illness. This...
The alignment between neural dynamics and environmental structures constitutes a fundamental challenge in neuroscience. While Georg Northoff's Temporo-Spatial Theory of Consciousness (TTC) posits a "common currency" of temporo-spatial dynamics, the mechanistic operationalization of this alignment remains unspecified. This report integrates the TTC with the Affective Criticality Hypo proposed by...
PsychopharmacologyMarch 4, 2026Ava M. Mac, Srinivasu Kallakuri, Alixandria T. Mascarin et al.
MDMA (3–4 methylenedioxymethamphetamine) assisted psychotherapy has gained considerable attention as a potential adjuvant therapy for post-traumatic stress disorder (PTSD). Reports of the nonmedical use of MDMA suggest its adverse effects may include anxiety and anhedonia. However, the time course of these signs and symptoms and the potential alterations in neurotransmitter levels that may...
Anxiety before a first-time screening colonoscopy is a commonly reported patient-level barrier to completing colorectal cancer (CRC) screening. This pilot study evaluated the feasibility, acceptability, and preliminary efficacy of "For peace of mind. Get Screened," a brief online mindfulness-based intervention (MBI) to reduce anxiety before a first-time screening colonoscopy. Participants (n =...
Introduction: This study examined the pathways linking mindfulness to emotion regulation and psychological symptoms among adults in Saudi Arabia. Methods: A total of 306 adults completed validated measures of mindfulness, emotion regulation (cognitive reappraisal and expressive suppression), depression, and anxiety. Structural equation modeling was used to test a hypothesized model in which...
Cannabis use is associated with psychiatric comorbidities, and the use of elta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) produces different neurophysiological and pharmacological effects. This study estimated the strength of associations between vaping of THC and CBD with depressive and anxiety symptoms in adolescents. Observational data were drawn from three years of the nationally...
PURPOSE: Increased depression, anxiety and stress symptoms are associated with reduced mindfulness levels and coping skills. This study primarily aimed to investigate (1) the relationships between mindfulness, coping styles, depression, anxiety and stress and (2) mindfulness and coping styles as predictors of depression, anxiety and stress in adults who stutter. A secondary aim was to compare...
Fear and anxiety perform essential protective roles, yet when they become dysregulated, they can trap trauma survivors in persistent hypervigilance and distress. Post-traumatic stress disorder (PTSD) manifests as intrusive memories, avoidance, and heightened arousal long after the precipitating event. Although current pharmacotherapies - including selective serotonin reuptake inhibitors,...
Psychological distress, including depression, anxiety, and stress, is highly prevalent among adults with cancer. Mindfulness-based interventions (MBIs), such as Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT), are increasingly used to address these symptoms. However, no prior review has comprehensively stratified MBI effects across intervention types,...
Mindfulness meditation, a slow breathing practice that is predicated on cultivating nonreactive awareness, also reduces pain. The existing literature has been mixed in demonstrating whether mindfulness meditation is more effective than slow breathing alone (ie, sham-mindfulness meditation) at reducing pain. Furthermore, smaller sample sizes in prior work have hindered a clear understanding of...
Psychospiritual distress (PSD) causes profound suffering in people with serious illness, yet treatment options are few and evidence of their efficacy is modest. Although high-level evidence is limited, decades of preliminary research suggest that psychedelic-assisted psychotherapy (PAP), including ketamine-assisted psychotherapy (KAP), may alleviate the anxiety, depression, and existential...
Background: Psychedelic therapies are gaining attention as tools to alleviate anxiety and depression across various clinical populations. However, the mechanisms behind psychedelics' therapeutic efficacy and the potential differences in how patients with certain diagnoses experience their subjective effects remain unknown. One commonly suggested mediator of positive outcomes across psychedelics...
Adolescent anxiety is a growing mental health concern, with prevalence reaching 3.7% in Indonesia, yet practical and effective school-based interventions remain limited. This study aims to examine the effectiveness of group counseling with the mindful breathing technique in reducing anxiety among students at SMA Model Terpadu Madani Palu. An experimental method with a Pretest-Posttest Control...
Scientific ReportsFebruary 28, 2026Patryk Główczyński, Paweł Dębski, Karina Badura-Brzoza
Spirituality and religiosity are increasingly examined as factors relevant to mental health, yet less is known about individualized nonreligious forms of spiritual practices. In this cross-sectional study, we investigated associations between spirituality, religious affiliation, non-religious forms of spiritual practices (NFSP) and symptoms of anxiety and depression in 1240 young adults aged...
Chronic kidney disease (CKD) is identified by a decrease in the glomerular filtration rate (GFR <60 mL/min/1.73) over a period of more than three months. Patients undergoing hemodialysis often experience anxiety due to the intense therapy routine and lifestyle limitations. This condition requires effective anxiety management. This study analyzes the effect of Mindfulness-Based Stress Reduction...
Background/Objectives: Mental health conditions such as anxiety, depression, and stress remain among the leading global causes of disability. Mindfulness-Based Interventions (MBIs) have gained increasing attention as effective non-pharmacological strategies for reducing psychological distress. Methods: This systematic review examined 30 randomized controlled trials and quasi-experimental...