Phantom limb pain (PLP) is a refractory condition defined by pain experienced in a missing limb. Psilocybin, a classical serotonergic psychedelic drug, can alleviate various treatment-resistant disorders but has scantly been investigated for chronic pain. This placebo-controlled, double-blind, randomized clinical pilot trial (NCT05224336) tested the feasibility, tolerability, and preliminary...
Introduction: Chronic low back pain (cLBP) is a leading cause of disability worldwide and is frequently refractory to pharmacological treatment. Mindfulness meditation has been shown to reduce pain through modulation of self-referential, cognitive and affective mechanisms. However, the neural mechanisms supporting the direct and immediate modulation of movement-evoked cLBP by mindfulness...
Mindfulness meditation, a slow breathing practice that is predicated on cultivating nonreactive awareness, also reduces pain. The existing literature has been mixed in demonstrating whether mindfulness meditation is more effective than slow breathing alone (ie, sham-mindfulness meditation) at reducing pain. Furthermore, smaller sample sizes in prior work have hindered a clear understanding of...