Psychedelics for anxiety disorders: Challenges and opportunities
Fundamental Research July 16, 2025 C-J Gao, Heming Cheng
A recent study published in Neuron by Tiwari et al . identified the critical role of 5-HT 2A receptor in ventral hippocampal parvalbumin (PV) interneurons (INs) in mediating the acute anxiolytic effects of the serotonergic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI). This study not only advances psychedelic neuropharmacology but also provides a robust framework for developing novel...