Current Topics in Behavioral Neurosciences
2017
Shawn. M. Aarde, Michael A. Taffe
Animal models of drug self-administration are currently the gold standard for making predictions regarding the relative likelihood that a recreational drug substance will lead to continued use and addiction. Such models have been found to have high predictive accuracy and discriminative validity for a number of drug classes including ethanol, nicotine, opioids, and psychostimulants such as...
Drug and Alcohol Dependence
June 1, 2015
Shawn. M. Aarde, Michelle L Miller, Kevin M Creehan et al.
Exercise influences drug craving and consumption in humans and drug self-administration in laboratory animals, but the effects can be variable. Improved understanding of how exercise affects drug intake or craving would enhance applications of exercise programs to human drug users attempting cessation. Rats were trained in the intravenous self-administration (IVSA) of D-methamphetamine (METH;...
Drug and Alcohol Dependence
June 3, 2012
Pai-Kai Huang, Shawn. M. Aarde, D. Angrish et al.
74 citations
BACKGROUND Reports from US, UK and European drug policy entities, and ongoing media accounts, show increasing recreational use of 4-methylmethcathinone (4-MMC, mephedrone) and 3,4-methylenedioxypyrovalerone (MDPV). Severe sympathomimetic symptoms, hallucinations, psychoses, and even deaths have been reported, yet little scientific information is available on the effects of these compounds in...
The FASEB Journal
April 1, 2012
Pai-Kai Huang, Shawn. M. Aarde, Tobin J. Dickerson et al.
A recent DEA report and ongoing media accounts show increasing recreational use of 4‐methylmethcathinone (4‐MMC, mephedrone) and 3,4‐methylenedioxypyrovalerone (MDPV). Some severe sympathomimetic symptoms, hallucinations, psychoses, and even deaths have been reported. Recent studies showed that 4‐MMC and MDPV enhanced DA neurotransmission, while 4‐MMC also increased 5‐HT neurotransmission, much...
bioRxiv (Cold Spring Harbor Laboratory)
Shawn. M. Aarde, Pai-Kai Huang, Michael A. Taffe
1 citation
preprint
Abstract Rationale MDMA alters body temperature in rats with a direction that depends on the ambient temperature (T A ). The thermoregulatory effects of MDMA and T A may affect intravenous self-administration (IVSA) of MDMA but limited prior reports conflict. Objective To determine how body temperature responses under high and low T A influence MDMA IVSA. Methods Male Sprague-Dawley rats were...