Brain Research Bulletin
1995
Henry Sershen, Audrey Hashim, Ábel Lajtha
25 citations
Ibogaine is an indole alkaloid that has been suggested to have potential efficacy for interrupting dependency on stimulant drugs. The kappa-opioid and serotonin 5-HT3 systems may be involved in the action of ibogaine, related to their modulation of dopaminergic transmission. The kappa-opioid agonist U 62066 attenuated the in vitro stimulation-evoked efflux of tritium label from striatal tissue...
Behavioural Brain Research
November 16, 1994
S L Cappendijk, D Fekkes, M R Dzoljic
57 citations
Norharman (20 mg/kg, i.p.) and ibogaine (40 mg/kg, i.p.) significantly attenuated naloxone (4 mg/kg, i.p.)-precipitated withdrawal syndrome in morphine-dependent rats. Several withdrawal signs, such as teeth-chattering, chewing, penile licking and diarrhoea, were decreased by both norharman and ibogaine. In addition, norharman reduced also the withdrawal grooming and rearing. It is concluded...
Psychopharmacology
November 1994
S G Holtzman
This study was performed to characterize pharmacologically the discriminative stimulus effects of dextromethorphan, an antitussive that binds with high affinity to a subtype of sigma site in the brain. Dextrorphan, a metabolite of dextromethorphan, has phencyclidine (PCP)-like effects. Therefore, training was conducted with dextromethorphan injected by the SC route, which minimizes dextrorphan...
Neurochemical Research
November 1, 1994
Henry Sershen, Audrey Hashim, Ábel Lajtha
23 citations
The effect of ibogaine (Endabuse, NIH 10567) on serotonin uptake and release, and on serotonergic modulation of dopamine release, was measured in striatal tissue from rats and mice. Two hours after treatment in vivo with ibogaine (40 mg/kg i.p.) the uptake of labeled [3H]serotonin and [3H]dopamine uptake in striatal tissue was similar in the ibogaine-treated animal to that in the control. The...
Alcoholism Treatment Quarterly
October 26, 1994
Hari M. Sharma, Micheal C. Dillbeck, Susan Levin Dillbeck
2 citations
The purpose of the proposed treatment program is to provide a holistic, natural approach to prevent alcohol and drug abuse among high-risk preadolescent and adolescent children by reducing psychological distress and physiological imbalance, and by enhancing protective resources through an individual and family program. To achieve this goal, juveniles referred for alcohol and drug abuse...
The Japanese Journal of Pharmacology
October 1994
K Kitaichi, K Yamada, T Hasegawa et al.
In this study, we investigated whether risperidone, a serotonin-S2A (5-HT2A)/dopamine-D2 (D2)-receptor antagonist, inhibits phencyclidine (PCP)-induced stereotyped behaviors in comparison with haloperidol and ritanserin. Moreover, we also attempted to investigate the effects of these antipsychotics on the contents of dopamine, serotonin (5-HT) and their metabolites in rat striatum and frontal...
Journal of Pharmacology and Experimental Therapeutics
October 1, 1994
Tissue levels of serotonin (5-HT), levels of its metabolite 5-hydroxyindoleacetic acid (5-HIAA) and populations of 5-HT reuptake sites were measured in the brains of rats exposed to 3,4-methylenedioxymethamphetamine (MDMA) at selected developmental ages. MDMA exposure at postnatal day (PND) 10 did not result in altered 5-HT or 5-HIAA levels 1 week after administration in any brain region...
Brain Research
September 19, 1994
Stanley D Glick, Martin E. Kuehne, J Raucci et al.
189 citations
Ibogaine, a naturally occurring alkaloid, has been claimed to be effective in treating addiction to opioid and stimulant drugs and has been reported to decrease morphine and cocaine self-administration in rats. The present study sought to determine if other iboga alkaloids, as well as the chemically related harmala alkaloid harmaline, would also reduce the intravenous self-administration of...
Drug Development Research
September 1, 1994
Charles W. Bradberry
14 citations
Abstract This overview summarizes the results of microdialysis studies into the effects of several psychoactive drugs on extracellular serotonin (5‐HT) levels in rat brain. The effects of (+)3,4‐methylenedioxymethamphetamine (MDMA, ecstasy) were examined in the brain slice preparation for comparison with parallel electrophysiological studies of the impact of (+)‐MDMA on dorsal raphe 5‐HT...
Anthropology of Consciousness
September 1, 1994
Roger W. Sperry, Polly Henninger
Traditional scientific views of the conscious self and world we live in are challenged by an unprecedented outburst of emerging new paradigms, theories of consciousness, perceptions of reality, new sciences, new philosophies, epistemologies, and a host of other transformative approaches. This still expanding outburst can be traced, on both logical and chronologic grounds, not to chaos theory,...