Neurochemical Research
May 6, 2026
Oyedayo Phillips Akano, Goodness Olatinwo, Moses Agbomhere Hamed et al.
3,4-Methylenedioxymethamphetamine (MDMA), widely misused for its euphoric and stimulant properties, induces overt neurotoxicity in rodents and non-human primates and is associated with profound neurochemical and structural brain alterations. Its deleterious effects are primarily mediated through oxidative stress, neuroinflammatory responses, and apoptotic pathways. Glutathione, a crucial...
Neurochemical Research
March 13, 2026
Lan Luo, Miao Yu, Xiaodong Li et al.
Traumatic brain injury (TBI) is a major global health issue leading to high mortality and disability. Activated astrocytes are one of the pivotal driving factors in the neuroinflammatory cascade following TBI. This study aims to investigate the role of esketamine on TBI and the underlying mechanism. Mice received a mouse weight-drop cortical impact or sham surgery and TBI mice were treated with...
Neurochemical Research
April 1, 2023
Jared VanderZwaag, Torin Halvorson, Kira Dolhan et al.
25 citations
There is much excitement surrounding recent research of promising, mechanistically novel psychotherapeutics - psychedelic, anesthetic, and dissociative agents - as they have demonstrated surprising efficacy in treating central nervous system (CNS) disorders, such as mood disorders and addiction. However, the mechanisms by which these drugs provide such profound psychological benefits are still...
Neurochemical Research
April 1, 2023
Maria Krassnitzer, Brooke Boisvert, Johannes Beiersdorf et al.
Cannabis legalization prompted the dilemma if plant-derived recreational drugs can have therapeutic potential and, consequently, how to address their regulation and safe distribution. In parallel, the steady worldwide decriminalization of cannabis and the enhanced content of its main psychoactive compound Δ9-tetrahydrocannabinol (THC), exposes populations to increasing amounts of cannabis and...
Neurochemical Research
October 1, 2014
Graham A R Johnston
Muscimol, a psychoactive isoxazole from Amanita muscaria and related mushrooms, has proved to be a remarkably selective agonist at ionotropic receptors for the inhibitory neurotransmitter GABA. This historic overview highlights the discovery and development of muscimol and related compounds as a GABA agonist by Danish and Australian neurochemists. Muscimol is widely used as a ligand to probe...
Neurochemical Research
August 1, 2000
M B Leal, D O De Souza, E Elisabetsky
23 citations
Ibogaine, a putative antiaddictive drug, is remarkable in its apparent ability to downgrade withdrawal symptoms and drug craving for extended periods of time after a single dose. Ibogaine acts as a non-competitive NMDA receptor antagonist, while NMDA has been implicated in long lasting changes in neuronal function and in the physiological basis of drug addiction. The purpose of this study was...
Neurochemical Research
November 1, 1994
Henry Sershen, Audrey Hashim, Ábel Lajtha
23 citations
The effect of ibogaine (Endabuse, NIH 10567) on serotonin uptake and release, and on serotonergic modulation of dopamine release, was measured in striatal tissue from rats and mice. Two hours after treatment in vivo with ibogaine (40 mg/kg i.p.) the uptake of labeled [3H]serotonin and [3H]dopamine uptake in striatal tissue was similar in the ibogaine-treated animal to that in the control. The...
Neurochemical Research
June 1, 1977
Nandkumar S. Shah, O. D. Dulati, D. A. Powell et al.
2 citations
Albino rabbits of either sex were anesthetized, and a cannula was implanted permanently into the lateral ventricle. About 1 week later, the distribution of [(14)C]mescaline and its deaminated metabolite, [(14)C]trimethoxyphenylacetic acid ([(14)C]TMPA) in 12 brain regions was examined at 15, 60, and 180 min after the intraventricular injection of [(14)C]mescaline (0.5 μmol in 0.05 ml...