The Neuroscientist
October 2007
Linda Chang, Edward P Chronicle
Cannabis remains the most widely used illegal drug in the United States. This update examines the available literature on neuroimaging studies of the brains of cannabis users. The majority of studies examining the acute effects of delta-9-tetrahydrocannabinol (THC) administration used PET methods and concluded that administration of THC leads to increased activation in frontal and paralimbic...
October 1, 2007
Steven Horst
AbstractContemporary debates in philosophy of mind‐between reductionists, dualists, nonreductive materialists, and eliminativists‐have been based upon the perception that mental phenomena like consciousness and intentionality are uniquely irreducible. The “explanatory gap” between mind and body seems to be an urgent and fascinating problem if one assumes that intertheoretic reductions are the...
Pharmacology, Biochemistry, and Behavior
October 2007
Kevin T. Ball, Kelly M Walsh, George V. Rebec
The widely used recreational drug MDMA (ecstasy) supports self-administration in animals, but it is not known whether MDMA-associated cues are able to reinstate drug seeking in a relapse model of drug addiction. To assess this possibility, drug-naïve rats were trained to press a lever for MDMA infusions (0.30 mg/kg/infusion, i.v.) paired with a compound cue (light and tone) in daily 2 h...
Drug Metabolism and Disposition
October 2007
Matthew L Banks, Jon E. Sprague, David F Kisor et al.
Changes in ambient temperature are known to alter both the hyperthermic and the serotonergic consequences of 3,4-methylenedioxymethamphetamine (MDMA). Metabolism of MDMA has been suggested to be a requisite for these neurotoxic effects, whereas the hyperthermic response is an important contributing variable. The aim of the present study was to investigate the interaction between ambient...
Pharmacology, Biochemistry, and Behavior
October 2007
Danuta Marona‐lewicka, David E Nichols
Activation of 5-HT(2A) receptors is thought to mediate the hallucinogenic effects of LSD. Nevertheless, in a previous report we provided evidence that a delayed temporal phase of the behavioral pharmacology of LSD is mediated by D(2)-like dopamine receptor stimulation. In this study rats were trained to discriminate LSD with either a 30 min preinjection time (LSD-30, N=12) or a 90 min...
Perceptual and Motor Skills
October 1, 2007
Michael Schredl
Whereas the effect of sex and age on dream recall have been studied widely, socioeconomic status has rarely been investigated. However, two studies reported that higher socioeconomic status was related to greater frequency of dream recall. In the present sample of 612 Chinese students from three different schools, one elite (high socioeconomic status), one rural (low socioeconomic status) and...
Addictive Behaviors
October 1, 2007
Sarah Bowen, Katie Witkiewitz, Tiara M Dillworth et al.
Previous studies have demonstrated that attempts to suppress thoughts about using substances may actually lead to increases in substance use. Vipassana, a mindfulness meditation practice, emphasizes acceptance, rather than suppression, of unwanted thoughts. A study by Bowen and colleagues examining the effects of a Vipassana course on substance use in an incarcerated population showed...
Pharmacology, Biochemistry, and Behavior
October 1, 2007
Jerrold C Winter, K C Rice, D J Amorosi et al.
73 citations
Although psilocybin has been trained in the rat as a discriminative stimulus, little is known of the pharmacological receptors essential for stimulus control. In the present investigation rats were trained with psilocybin and tests were then conducted employing a series of other hallucinogens and presumed antagonists. An intermediate degree of antagonism of psilocybin was observed following...
PLoS Biology
September 25, 2007
Antoine del Cul, Sylvain Baillet, Stanislas Dehaene
When a flashed stimulus is followed by a backward mask, subjects fail to perceive it unless the target-mask interval exceeds a threshold duration of about 50 ms. Models of conscious access postulate that this threshold is associated with the time needed to establish sustained activity in recurrent cortical loops, but the brain areas involved and their timing remain debated. We used high-density...
September 21, 2007
Jeff Buechner
The first systematic examination of Hilary Putnam's arguments against computational functionalism challenges each of Putnam's main arguments. With mind-brain identity theories no longer dominant in philosophy of mind in the late 1950s, scientific materialists turned to functionalism, the view that the identity of any mental state depends on its function in the cognitive system of which it is a...