Addiction
February 10, 2007
Matthew Hickman, Peter T. Vickerman, John Macleod et al.
97 citations
AIMS: To estimate long-term trends in cannabis use and projections of schizophrenia assuming a causal relation between cannabis use and schizophrenia. METHODS: Trends in cannabis use were estimated from a national survey, 2003; and incidence of schizophrenia was derived from surveys in three English cities, 1997-99. A difference equation cohort model was fitted against estimates of...
Journal of Pharmacology and Experimental Therapeutics
February 2007
Paul J Gresch, Robert J. Barrett, Elaine Sanders‐bush et al.
d-Lysergic acid diethylamide (LSD), an indoleamine hallucinogen, produces profound alterations in mood, thought, and perception in humans. The brain site(s) that mediates the effects of LSD is currently unknown. In this study, we combine the drug discrimination paradigm with intracerebral microinjections to investigate the anatomical localization of the discriminative stimulus of LSD in rats....
The California journal of emergency medicine
February 1, 2007
T. Bey, Anar J. Patel
The California Journal of Emergency Medicine VIII:1 February 2007 Page Clinical Review Phencyclidine Intoxication and Adverse Effects: A Clinical and Pharmacological Review of an Illicit Drug Tareg Bey, MD and Anar Patel, MD Department of Emergency Medicine, University of California, Irvine, Medical Center Orange, California. Correspondence: Tareg Bey, MD, FACEP, FAAEM Department of Emergency...
Journal of Pharmacology and Experimental Therapeutics
February 1, 2007
Richard B Rothman, Daniel L Murphy, Heng Xu et al.
75 citations
Salvinorin A [(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-2h-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester] is a hallucinogenic kappa-opioid receptor agonist that lacks the usual basic nitrogen atom present in other known opioid ligands. Our first published studies indicated that Salvinorin A weakly inhibited mu-receptor binding, and...
European Journal of Pharmacology
January 26, 2007
Daniela Braida, Valeria Limonta, Lorenzo Malabarba et al.
The mechanism mediating the effects of cannabinoids on anxiety-related responses appear to involve cannabinoid CB1 and non-CB1 receptors. However, other neurotransmitters may play a role in such effect. This study shows evidence of an interaction between endocannabinoid system and serotonin (5-HT), 1A receptor subtype on anxiety-like behavior in Sprague-Dawley rats. The exogenous cannabinoid...
Journal of Neurochemistry
January 22, 2007
Elio Acquas, Augusta Pisanu, Saturnino Spiga et al.
52 citations
Abstract R,S(±)‐3,4‐methylenedioxymethamphetamine (R,S(±)‐MDMA, ‘Ecstasy’) is known to stimulate dopamine (DA) transmission in the nucleus accumbens (NAc). In order to investigate the post‐synaptic correlates of pre‐synaptic changes in DA transmission and their relationship with MDMA enantiomers, we studied the effects of R,S(±)‐MDMA, S(+)‐MDMA, and R(−)‐MDMA on extracellular DA and...
Journal of The American Geriatrics Society
2007
Colin S. Tan, Kah-Guan Au Eong
2 citations
To the Editor: We read with interest the report by Drs. McKoy and McGartland describing visual hallucinations in an elderly woman.1 Their patient had several ocular conditions that are known to be associated with Charles Bonnet syndrome (CBS)—retinitis pigmentosa, cataracts, and, possibly, angle-closure glaucoma (as evidenced by the bilateral iridectomies). In addition, the patient was elderly,...
Neuroscience and biobehavioral reviews
2007
Kelly Allott, Jennifer Redman
Sex has been identified as an important factor in moderating the effects of several drugs of abuse. Given the increasing popularity of ecstasy (3,4-methylenedioxymethamphetamine [MDMA]) use, it is important for researchers and clinicians to understand the factors that may influence its pharmacological actions to improve education, harm reduction and treatment efforts. This review focuses on...
Critical reviews in neurobiology
2007
Chad R. Edwards, Patrick D. Skosnik
Delta-9-tetrahydrocannabinol (THC) is the primary psycho-active ingredient in Cannabis spp., the most widely used illicit drug in the United States. THC is an exogenous agonist of the central cannabinoid receptor (CB1), one of the most abundant G-coupled receptors in the mammalian brain. Although CB1 receptors are distributed throughout the brain, they are found at very high levels in the...
Neurosciences
2007
B. Issa
Cannabis is one of the oldest, and one of the most widely abused substances. It is available in all parts of the world where it is used commonly as a recreational drug when smoked or consumed in some other ways. It also has some medicinal potential, the reason for which some are calling for its legalization. Cannabis has been associated with several psychiatric problems such as anxiety...