Scientific Reports
June 24, 2024
Srishti Rana, Jeremy R Canfield, Christopher S Ward et al.
5 citations
Hyperthermia induced by phenethylamines, such as 3,4-methylenedioxymethamphetamine (MDMA), can lead to life-threatening complications and death. Activation of the sympathetic nervous system and subsequent release of norepinephrine and activation of uncoupling proteins have been demonstrated to be the key mediators of phenethylamine-induced hyperthermia (PIH). Recently, the gut microbiome was...
European Journal of Pharmacology
April 15, 2023
Amal Aburahma, Srishti Rana, Ray A. Larsen et al.
5 citations
The increased use of the stimulant drug, 3,4-methylenedioxymethamphetamine (MDMA), more commonly known as Ecstasy, Molly or X, has been linked to the development of life-threatening hyperthermia in human and animal models. The current study aimed to investigate the role of the gut-adrenal axis in MDMA-induced hyperthermia by assessing the influence of the acute exogenous supplementation with...
Scientific Reports
March 13, 2019
Emily Ridge, Sudhan Pachhain, S. Choudhury et al.
25 citations
Hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) can be life-threatening. Here, we investigate the role of the gut microbiome and TGR5 bile acid receptors in MDMA-mediated hyperthermia. Fourteen days prior to treatment with MDMA, male Sprague-Dawley rats were provided water or water treated with antibiotics. Animals that had received antibiotics displayed a reduction in gut...
Psychopharmacology
January 2008
Matthew L Banks, Jon E. Sprague, Paul W Czoty et al.
3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is frequently used in hot environments, such as rave parties. Studies in laboratory animals have shown that ambient temperature can alter the behavioral and neurochemical effects of MDMA. To examine the influence of ambient temperature on the relative reinforcing strength of MDMA and reinstatement of behavior previously maintained by MDMA is the...
Drug metabolism and disposition: the biological fate of chemicals
October 2007
Matthew L Banks, Jon E. Sprague, David F Kisor et al.
Changes in ambient temperature are known to alter both the hyperthermic and the serotonergic consequences of 3,4-methylenedioxymethamphetamine (MDMA). Metabolism of MDMA has been suggested to be a requisite for these neurotoxic effects, whereas the hyperthermic response is an important contributing variable. The aim of the present study was to investigate the interaction between ambient...
Critical Care Medicine
June 1, 2005
Jon E. Sprague, Petra Moze, David Caden et al.
75 citations
These data show that alpha1 and beta3-adrenergic receptors may contribute to the mediation of MDMA-induced hyperthermia and that drugs targeting these receptors, such as carvedilol, warrant further investigation as novel therapies for the treatment of psychostimulant-induced hyperthermia and its sequelae.
British Journal of Pharmacology
June 1, 2004
Jon E. Sprague, Robert E. Brutcher, Edward Mills et al.
53 citations
Studies were designed to examine the effects of α 1 ( α 1 AR)‐ plus β 3 ‐adrenoreceptor ( β 3 AR) antagonists on 3,4‐methylenedioxymethamphetamine (MDMA, Ecstasy)‐induced hyperthermia and measures of rhabdomyolysis (creatine kinase (CK)) and renal function (blood urea nitrogen (BUN) and serum creatinine (sCr)) in male Sprague–Dawley rats. MDMA (40 mg kg −1 , s.c.) induced a rapid and robust...