Psychology and AgingSeptember 1, 2011Brennan R. Payne, Joshua J. Jackson, S. R. Noh et al.
The current study investigated the nature of the flow state among older adults. Flow is a pleasurable experiential state that occurs during full-capacity engagement in which an individual is performing at a level that is matched with the demands of the task. Each participant completed a scale assessing dimensions of flow in a particular activity selected by the participant. More cognitively...
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties, thus providing a valuable research tool for the investigation of the neurobiology of major depressive disorder (MDD). Increasing evidence underscores the role of glutamate dependent neuroplasticity and glutamatergic neurotransmission and metabolism in the pathophysiology of MDD. This multimodal...
We propose a concise novel conceptual and biological framework for the analysis of primary visual perception (PVP) that refers to the most basic levels of our awake subjective visual experiences. Neural representations for image content elaborated within V1/V2 and the early occipitotemporal (ventral) loop remain only latent with respect to PVP until spatially localized with respect to an...
Salvinorin A, the main active component of Salvia divinorum, is a potent and selective κ opioid receptor agonist. Synthetic derivatives of this substance may be useful in the development of medicinal treatments for pain, mood disorders, and drug dependence. Such developments require extensive preclinical screening of these compounds. The drug discrimination assay is a valuable method for...
The 2C, 2C-T, and DO series of designer drugs pose a number of challenges to forensic toxicology laboratories. Although these drugs are seized by law enforcement agencies throughout the United States, they are not readily detected in forensic toxicology laboratories. A systematic evaluation of the cross-reactivity of 9 commercial enzyme-linked immunosorbent assays (ELISAs) was conducted using...
What are the ethical obligations of a researcher who wishes to study another culture's ceremonial practices, in particular those of the Native American Church (NAC)? What promise do peyote and the NAC peyote ceremony show for the treatment of alcoholism amongst NAC members? How does one approach the philosophical issues regarding “consciousness” within the context of such a study? In this...
18-Methoxycoronaridine (18-MC), a putative anti-addictive agent, has been shown to decrease the self-administration of several drugs of abuse in rats. 18-MC is a potent antagonist at α3β4 nicotinic receptors. Consistent with high densities of α3β4 nicotinic receptors being located in the medial habenula and the interpeduncular nucleus, 18-MC has been shown to act in these regions to decrease...
All articles of this category Kernaussagen Psychotische Rauschverläufe und rauschüberdauernde drogeninduzierte Psychosen kommen bei einer Vielzahl von Drogen vor, die über verschiedene pharmakologische Akutmechanismen wirken. Hierzu gehören Cannabis, Stimulanzien, Ecstasy und Halluzinogene. In der Regel lässt sich aus klinischen und experimentellen Befunden eine Dosisabhängigkeit ableiten,...
Background: Synthetic cannabinoids are a rapidly emerging class of abused drugs. Synthetic cannabinoids are typically sold as "herbal blends" or "incense," commonly referred to as Spice products. No controlled human experiments have been conducted on the effects of Spice products or the synthetic cannabinoids they often contain. Methods: An internet-based survey study was conducted with adults...
Motor activity in rapid eye movement (REM) sleep behaviour disorder (RBD) has been linked to dream content. Systematic and controlled sleep laboratory studies directly assessing the relation between RBD behaviours and experienced dream content are, however, largely lacking. We aimed to investigate whether a link can be established between RBD behaviours and dream content when both are...