There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key uncertainty is whether there is a finite speed limit imposed by the critical role of homeostatic adaptive mechanisms that underpin the efficacy and onset of available...
Recreational drugs such as 3,4-methylenedioxymethamphetamine and cocaine induce hyperthermia, which is affected by ambient temperature. 2-(4-Bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B-NBOMe), a selective agonist of 5-HT2A receptor used as a recreational drug, reportedly induces hyperthermia. This study aimed to verify whether 25B-NBOMe induces ambient temperature-dependent...
PsyArXivOctober 29, 2018Michael C Mullarkey, Mallory Dobias, Karen Bluth
preprint
Disentangling the unique associations of self-compassion and mindfulness with adolescent depression has been an empirical challenge. Taking a symptom-level approach to adolescent depression using network analysis can address some of the most common conceptual and psychometric challenges in this area. Under this network analysis framework, some symptoms are more central, or predictive of the...
Ibogaine is a psychedelic alkaloid which has been subject of intense scientific research due to its reported ability to attenuate drug-seeking behavior. Recent work suggested that ibogaine effects on alcohol self-administration in rats was related to the release of Glial Cell Derived Neurotrophic Factor (GDNF) in the Ventral Tegmental Area (VTA), a mesencephalic region which hosts soma of...
Traveling to novel destinations can give rise to a state of attention referred to here as a “traveler’s mind”—a state in which two forms of a popular concept in management and organization studies, mindfulness, occur in tandem. In this essay, written as a personal narrative, I explore the nature of a traveler’s mind, discuss the conditions under which this state of attention is most likely to...
Objectives Nightmare is one of the sleep problems among adolescents.This research aimed to examine multiple relations among thought control strategies and symptoms of personality disorders among female students in Shahreza City, Iran in 2015-2016.Methods In this correlational study, the statistical population comprised all female students in pre-university schools and the sample was 300 girls...
Bodhidharma replied, “Although the mind of ignorance has eighty-four thousand passions and cravings which defile it, as well as evils as immeasurable and unbounded as the sands of the Ganges, ultimately all depend on the three poisons and have them as their root and source. All sentient beings throw their bodies and minds into confusion and disorder as a result of the three poisons and through...
Consciousness and working memory (WM) have been thought to be closely related, but their exact relationship has remained unclear. The present study focused on the question whether visual awareness, the subjective experience of seeing, depends on resources of WM. Three dual-task experiments were run. The participants were asked to report their awareness of a low-contrast target stimulus while...
ThoraxOctober 18, 2018Ann Marie Parker, Albahi M. Malik, Megan M. Hosey4 citations
Depressive, anxiety and post-traumatic stress disorder (PTSD) symptoms are common, long-lasting and associated with worse quality of life among intensive care unit (ICU) survivors.1–4 There are few clinical trials evaluating interventions to improve these symptoms. Cox and colleagues evaluated the feasibility of a mobile mindfulness training application (App) to address psychological stress...
BACKGROUND: Diet patterns have a profound influence on glycemic control for individuals with type 2 diabetes mellitus (T2DM), and craving-related eating is an important obstacle to dietary adherence. A growing body of research suggests that carbohydrate-restricted (CR) diets can improve glycemic control and reduce medication dependence in T2DM. However, limited data speak to the effects of...